Analysis of the interactions between small pulmonary nodules, clinical factors and the risk of malignancy in the chest following diagnosis of head and neck cancer.
Human Papillomavirus
follow-up
head and neck cancer
pulmonary nodules
risk factors
Journal
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
ISSN: 1749-4486
Titre abrégé: Clin Otolaryngol
Pays: England
ID NLM: 101247023
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
18
01
2022
received:
30
09
2021
accepted:
13
02
2022
pubmed:
26
2
2022
medline:
22
4
2022
entrez:
25
2
2022
Statut:
ppublish
Résumé
This study aims to investigate radiological and clinical factors which predict malignancy in indeterminate pulmonary nodules in patients with head and neck cancer (HNC). Prospective data were collected in 424 patients who were reviewed in the NHS Lothian HNC multidisciplinary meeting from May 2016 to May 2018. Staging and follow-up CT chest imaging were reviewed to identify and assess pulmonary nodules in all patients. About 61.8% of patients had at least one pulmonary nodule at staging CT. In total, 25 patients developed malignancy in the chest. Metastatic disease in the chest was significantly associated with unknown or negative p16 status (p < .0005). Pleural indentation and spiculation were associated with indeterminate nodules, subsequently being shown to represent metastatic disease (p > .0005 and p = .046, respectively). Negative or unknown p16 status was associated with an increased propensity to develop metastatic disease in the chest in patients with HNC.
Sections du résumé
BACKGROUND
This study aims to investigate radiological and clinical factors which predict malignancy in indeterminate pulmonary nodules in patients with head and neck cancer (HNC).
METHODS
Prospective data were collected in 424 patients who were reviewed in the NHS Lothian HNC multidisciplinary meeting from May 2016 to May 2018. Staging and follow-up CT chest imaging were reviewed to identify and assess pulmonary nodules in all patients.
RESULTS
About 61.8% of patients had at least one pulmonary nodule at staging CT. In total, 25 patients developed malignancy in the chest. Metastatic disease in the chest was significantly associated with unknown or negative p16 status (p < .0005). Pleural indentation and spiculation were associated with indeterminate nodules, subsequently being shown to represent metastatic disease (p > .0005 and p = .046, respectively).
CONCLUSION
Negative or unknown p16 status was associated with an increased propensity to develop metastatic disease in the chest in patients with HNC.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-463Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
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