Thermal quantitative sensory testing as a screening tool for cardiac autonomic neuropathy in patients with diabetes mellitus.
autonomic nervous system
diabetic neuropathy
small fiber neuropathy
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
14
11
2021
received:
03
08
2021
accepted:
02
01
2022
pubmed:
26
2
2022
medline:
3
5
2022
entrez:
25
2
2022
Statut:
ppublish
Résumé
Electrophysiological diagnosis of cardiac autonomic neuropathy (CAN) is based on the evaluation of cardiovascular autonomic reflex tests (CARTs). CARTs are relatively time consuming and must be performed under standardized conditions. This study aimed to determine whether thermal quantitative sensory testing (TQST) can be used as a screening tool to identify patients with diabetes at a higher risk of CAN. Eighty-five patients with diabetes and 49 healthy controls were included in the study. Neurological examination, CARTs, TQST, biochemical analyses, and neuropathy symptom questionnaires were performed. CAN was diagnosed in 46 patients with diabetes (54%). CAN-positive patients with diabetes had significantly higher warm detection thresholds (WDT) and significantly lower cold detection thresholds (CDT) in all tested regions (thenar, tibia, and the dorsum of the foot). CDT on the dorsum < 21.8°C in combination with CDT on the tibia < 23.15°C showed the best diagnostic ability in CAN prediction, with 97.4 % specificity, 60.9% sensitivity, 96.6% positive predictive value, and 67.3% negative predictive value. TQST can be used as a screening tool for CAN before CART.
Identifiants
pubmed: 35212197
doi: 10.1002/brb3.2506
pmc: PMC8933758
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2506Informations de copyright
© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
Références
Brain Behav. 2022 Mar;12(3):e2506
pubmed: 35212197
J Neurol Neurosurg Psychiatry. 1976 Nov;39(11):1071-5
pubmed: 188989
World J Diabetes. 2018 Jan 15;9(1):1-24
pubmed: 29359025
Clin Neurol Neurosurg. 2006 Jul;108(5):477-81
pubmed: 16150538
Diabetes Care. 2017 Jan;40(1):136-154
pubmed: 27999003
Diabetes Metab J. 2019 Feb;43(1):3-30
pubmed: 30793549
Ann Neurol. 1978 Dec;4(6):502-10
pubmed: 742850
Diabetes Care. 2003 May;26(5):1553-79
pubmed: 12716821
Muscle Nerve. 2015 Sep;52(3):363-70
pubmed: 25556884
Curr Med Res Opin. 2006 Oct;22(10):1911-20
pubmed: 17022849
Neurology. 2011 Mar 22;76(12):1099-105
pubmed: 21422460
Diabetes Care. 2012 Apr;35(4):809-16
pubmed: 22357183
F1000Res. 2019 Feb 15;8:
pubmed: 30828432
Pain Pract. 2017 Apr;17(4):514-521
pubmed: 27538385
Diabetes Metab Syndr Obes. 2019 Apr 30;12:581-587
pubmed: 31118721
Diabetes Metab Res Rev. 2011 Oct;27(7):639-53
pubmed: 21695768
Diabetes Metab. 2013 Apr;39(2):126-31
pubmed: 23159130
Pain. 2010 Dec;151(3):598-605
pubmed: 20965658
J Clin Endocrinol Metab. 2005 Oct;90(10):5896-903
pubmed: 16014401
Diabetes Care. 2006 Feb;29(2):334-9
pubmed: 16443883
Diabet Med. 2012 Jul;29(7):937-44
pubmed: 22417277
J Peripher Nerv Syst. 2008 Sep;13(3):218-27
pubmed: 18844788
Arq Bras Cardiol. 2008 Apr;90(4):e24-31
pubmed: 18516377
Diabetes Res Clin Pract. 2018 Jun;140:18-26
pubmed: 29596945
Diabetes Ther. 2020 Apr;11(4):979-986
pubmed: 32172390
Diabetes Care. 2004 Dec;27(12):2942-7
pubmed: 15562211
Diabetes Care. 2005 Apr;28(4):956-62
pubmed: 15793206
PLoS One. 2015 Oct 12;10(10):e0138224
pubmed: 26457582
BMJ Open. 2015 Jun 24;5(6):e006559
pubmed: 26109108