Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
10 03 2022
10 03 2022
Historique:
pubmed:
26
2
2022
medline:
19
4
2022
entrez:
25
2
2022
Statut:
ppublish
Résumé
Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer and considered a potential target for therapeutic intervention. 4-(Diethylamino)benzaldehyde (DEAB) has been extensively reported as a pan-inhibitor of ALDH isoforms, and here, we report on the synthesis, ALDH isoform selectivity, and cellular potencies in prostate cancer cells of 40 DEAB analogues; three analogues (
Identifiants
pubmed: 35212533
doi: 10.1021/acs.jmedchem.1c01367
pmc: PMC9007462
doi:
Substances chimiques
Benzaldehydes
0
4-(diethylamino)benzaldehyde
120-21-8
Aldehyde Dehydrogenase
EC 1.2.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3833-3848Subventions
Organisme : Prostate Cancer UK
ID : S12-027
Pays : United Kingdom
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