Analysis of the Sphingolipidome in NAFLD.
Alcoholic fatty liver disease
Ceramide
Lipid
Lipidomics
Metabolic syndrome
NAFLD
NASH
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Sphingoid
Sphingolipids
Sphingosine
Sphingosine-1-phosphate
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
3
3
2022
Statut:
ppublish
Résumé
The relationship between sphingolipid levels and NAFLD pathology has been recognized for some time. Numerous studies using pharmacological and genetic approaches in vitro and in animal models of NAFLD have demonstrated that modifications to sphingolipid metabolism can attenuate various facets of NAFLD pathology. However, a more precise understanding of the role of sphingolipids and NAFLD pathology is essential to creating therapeutics that target this pathway. This chapter touches on the scale and variety of sphingolipid metabolites at play in NAFLD, which vary widely in their chemical structures and biological functions. With advances in liquid chromatography and tandem mass spectrometry approaches, each of thousands of individual sphingolipid species and sphingolipid metabolites can be identified and precisely quantified. These approaches are beginning to reveal specific sub-classes and species of sphingolipids that change in NAFLD, and as such, enzymes that generate them can be identified and potentially serve as therapeutic targets. Advances in lipidomics technology have been, and will continue to be, critical to these gains in our understanding of NAFLD.
Identifiants
pubmed: 35213002
doi: 10.1007/978-1-0716-2128-8_22
pmc: PMC9159091
mid: NIHMS1808738
doi:
Substances chimiques
Sphingolipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
279-303Subventions
Organisme : BLRD VA
ID : I01 BX000200
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151243
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016059
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
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