Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers.
delayed-release formulations
fat imaging
large intestine
magnetic resonance imaging
targeted drug delivery
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
24 Jan 2022
24 Jan 2022
Historique:
received:
16
11
2021
revised:
30
12
2021
accepted:
19
01
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
27
2
2022
Statut:
epublish
Résumé
Oral specially coated formulations have the potential to improve treatment outcomes of a range of diseases in distal intestinal tract whilst limiting systemic drug absorption and adverse effects. Their development is challenging, partly because of limited knowledge of the physiological and pathological distal gastrointestinal factors, including colonic chyme fluid distribution and motor function. Recently, non-invasive techniques such as magnetic resonance imaging (MRI) have started to provide novel important insights. In this feasibility study, we formulated a coated capsule consisting of a hydroxypropyl methylcellulose (HPMC) shell, coated with a synthetic polymer based on polymethacrylate-based copolymer (Eudragit
Identifiants
pubmed: 35214003
pii: pharmaceutics14020270
doi: 10.3390/pharmaceutics14020270
pmc: PMC8879863
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Institute for Health Research
ID : Biomedical Research Centre, Gastrointestinal and Liver Disease Theme core grant
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