Liver Injury in Patients Hospitalized for COVID-19: Possible Role of Therapy.
COVID-19
NIV
SARS-CoV2
drugs
injury
liver
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
26 Jan 2022
26 Jan 2022
Historique:
received:
31
12
2021
revised:
21
01
2022
accepted:
23
01
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
27
2
2022
Statut:
epublish
Résumé
Patients with COVID-19 show a high prevalence of liver injury. The pattern of this liver damage is still not fully understood. Different etiopathogenetic factors may concur; from a direct cytopathic effect, once the virus binds to the ACE-2 receptors, to the immune-mediated collateral damage, due to cytokine storm. The presence of pre-existing chronic liver disease is a contributing factor for acute organ damage during SARS-CoV2 infection. Last but not least, treatments probably play a role, also, in determining hepatotoxicity: many of the drugs we have used or are still using to treat COVID-19, combined with non-invasive ventilation, are known to sometimes determine acute liver injury. Although liver damage associated with COVID-19 is often transient and can resolve without any special treatment, it is important to understand the underlying mechanisms, particularly to better treat its more severe forms.
Identifiants
pubmed: 35214651
pii: vaccines10020192
doi: 10.3390/vaccines10020192
pmc: PMC8880796
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Hepatol. 2020 Oct;73(4):807-816
pubmed: 32437830
N Engl J Med. 2020 Dec 3;383(23):2255-2273
pubmed: 33264547
Infection. 2022 Feb;50(1):27-41
pubmed: 34331674
Clin Liver Dis. 2007 Aug;11(3):525-48, vi
pubmed: 17723918
Cureus. 2020 Jul 27;12(7):e9424
pubmed: 32864250
Crit Care. 2020 May 6;24(1):198
pubmed: 32375845
Lancet Gastroenterol Hepatol. 2020 May;5(5):428-430
pubmed: 32145190
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Circulation. 2006 Apr 18;113(15):e698-702
pubmed: 16618822
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Clin Microbiol Infect. 2021 Apr;27(4):520-531
pubmed: 33418017
N Engl J Med. 2021 Aug 26;385(9):790-802
pubmed: 34351721
Aliment Pharmacol Ther. 2007 May 15;25(10):1135-51
pubmed: 17451560
JAMA. 2021 May 4;325(17):1731-1743
pubmed: 33764378
J Clin Med. 2021 Sep 28;10(19):
pubmed: 34640480
Lancet. 2021 May 01;397(10285):1637-1645
pubmed: 33933206
JAMA Intern Med. 2021 Jan 1;181(1):24-31
pubmed: 33080005
Therapie. 2020 Jul - Aug;75(4):355-362
pubmed: 32418728
Gastroenterology. 2015 Jun;148(7):1340-52.e7
pubmed: 25754159
Pharmacoepidemiol Drug Saf. 2018 Nov;27(11):1174-1181
pubmed: 30112779
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Front Immunol. 2020 Jun 16;11:1446
pubmed: 32612617
Infect Dis Ther. 2022 Feb;11(1):231-248
pubmed: 34757578
Physiol Genomics. 2020 Nov 1;52(11):549-557
pubmed: 32991251
Pharmacotherapy. 2020 Aug;40(8):843-856
pubmed: 32542785
Drug Ther Bull. 2020 May;58(5):69
pubmed: 32234728
J Steroid Biochem Mol Biol. 2015 Nov;154:94-103
pubmed: 26241028
Respirology. 2021 Nov;26(11):1027-1040
pubmed: 34605114
Respir Med. 2021 Mar;178:106323
pubmed: 33545499
Intensive Care Med. 1996 Nov;22(11):1274-5
pubmed: 9120128
BMJ. 2021 Oct 14;375:n2400
pubmed: 34649864
J Hepatol. 2019 Jun;70(6):1222-1261
pubmed: 30926241
Clin Med (Lond). 2016 Dec;16(Suppl 6):s104-s109
pubmed: 27956449
Lancet Respir Med. 2021 Dec;9(12):1407-1418
pubmed: 34480861
JAMA. 2020 Oct 6;324(13):1330-1341
pubmed: 32876694
J Clin Pharmacol. 2020 Dec;60(12):1671-1678
pubmed: 32639644
Dig Liver Dis. 2021 Feb;53(2):158-165
pubmed: 32873520
Nat Med. 2021 Oct;27(10):1752-1760
pubmed: 34480127
Drug Saf. 2020 Aug;43(8):691-698
pubmed: 32696429
Infection. 2021 Aug;49(4):591-605
pubmed: 33709380
Hum Vaccin Immunother. 2017 Sep 2;13(9):1972-1988
pubmed: 28841363
Eur Respir Rev. 2021 Oct 20;30(162):
pubmed: 34670808
Expert Rev Anti Infect Ther. 2021 Sep 29;:1-10
pubmed: 34538216
Curr Drug Metab. 2018;19(10):830-838
pubmed: 29788883
Arthritis Rheum. 2003 Apr;48(4):927-34
pubmed: 12687534
J Dig Dis. 2019 Mar;20(3):122-126
pubmed: 30582289
Saudi Pharm J. 2020 Nov;28(11):1326-1332
pubmed: 32904846
Int Immunopharmacol. 2016 Nov;40:318-326
pubmed: 27664570
Pharmacotherapy. 2001 Jan;21(1):108-13
pubmed: 11191729
Adv Pharmacol. 2019;85:263-272
pubmed: 31307590
New Horiz. 1994 Nov;2(4):488-504
pubmed: 7804798
J Clin Epidemiol. 1993 Nov;46(11):1331-6
pubmed: 8229111
Crit Care. 2021 Jul 30;25(1):268
pubmed: 34330320
NPJ Genom Med. 2020 Aug 18;5:35
pubmed: 32864162
Biochem Biophys Res Commun. 2020 May 21;526(1):135-140
pubmed: 32199615
N Engl J Med. 2021 Aug 26;385(9):777-789
pubmed: 34351722
Int J Antimicrob Agents. 2020 Aug;56(2):106053
pubmed: 32534189
Med Mal Infect. 2020 Jun;50(4):384
pubmed: 32240719
Cornea. 2019 Jan;38(1):123-126
pubmed: 30371567
Intensive Care Med. 2006 Feb;32(2):267-274
pubmed: 16450099
Arch Toxicol. 2020 Oct;94(10):3381-3407
pubmed: 32852569
Crit Care. 2007;11(1):R13
pubmed: 17261192
Drug Saf Case Rep. 2015 Dec;2(1):17
pubmed: 27747729
Eur Rev Med Pharmacol Sci. 2017 Mar;21(1 Suppl):112-121
pubmed: 28379588
Gut. 2021 Apr;70(4):733-742
pubmed: 32641471
Front Pharmacol. 2019 Jul 23;10:730
pubmed: 31396080
Am J Med Sci. 2021 Nov 6;:
pubmed: 34752741
Hepatol Int. 2020 Sep;14(5):711-722
pubmed: 32623633
Clin Infect Dis. 2021 May 4;72(9):e373-e381
pubmed: 32785710
Clin Exp Pharmacol Physiol. 2020 Aug 7;:
pubmed: 32767405
Gut. 2005 Dec;54(12):1790-6
pubmed: 16166274
JAMA. 2003 Sep 17;290(11):1505-9
pubmed: 13129992
Int J Antimicrob Agents. 2020 Aug;56(2):106024
pubmed: 32450197
Biochimie. 2020 Dec;179:266-274
pubmed: 32891697
J Med Internet Res. 2020 Aug 13;22(8):e20193
pubmed: 32707537
JAMA. 2021 Apr 27;325(16):1620-1630
pubmed: 33734299
Int J Antimicrob Agents. 2020 Oct;56(4):106143
pubmed: 32853672
Respir Res. 2020 Dec 1;21(1):318
pubmed: 33261606
N Engl J Med. 2020 Nov 5;383(19):1813-1826
pubmed: 32445440
Minerva Med. 2021 Oct 21;:
pubmed: 34672164
Clin Gastroenterol Hepatol. 2015 Feb;13(2):369-376.e3
pubmed: 25111234
N Engl J Med. 2020 Nov 19;383(21):2041-2052
pubmed: 32706953
Hepatol Commun. 2020 Mar 13;4(5):631-645
pubmed: 32363315
Endocrinol Diabetes Metab Case Rep. 2019 Sep 27;2019:
pubmed: 31600730
Semin Liver Dis. 2002;22(2):185-94
pubmed: 12016549
Eur Respir J. 2017 Sep 10;50(3):
pubmed: 28890434
Clin Liver Dis. 2012 May;16(2):231-45
pubmed: 22541696
Ann Gastroenterol. 2016 Oct-Dec;29(4):454-459
pubmed: 27708510
Clin Pharmacol Ther. 2012 Aug;92(2):214-20
pubmed: 22739141
Expert Rev Gastroenterol Hepatol. 2020 Oct;14(10):873-876
pubmed: 32643980
Int J Antimicrob Agents. 2020 Jul;56(1):105949
pubmed: 32205204