Repurposing Antifungals for Host-Directed Antiviral Therapy?
antifungals
azoles
drug repurposing
echinocandins
host-directed drug therapy
polyenes
viral infections
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
10 Feb 2022
10 Feb 2022
Historique:
received:
16
12
2021
revised:
04
02
2022
accepted:
08
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
27
2
2022
Statut:
epublish
Résumé
Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that hide from immune cell and antibody detection. Thus, other approaches than immunization are critical for the management and control of viral infections. Viruses are prone to mutations leading to the rapid emergence of resistant strains upon treatment with direct antivirals. In contrast to the direct interference with pathogen components, host-directed therapies aim to target host factors that are essential for the pathogenic replication cycle or to improve the host defense mechanisms, thus circumventing resistance. These relatively new approaches are often based on the repurposing of drugs which are already licensed for the treatment of other unrelated diseases. Here, we summarize what is known about the mechanisms and modes of action for a potential use of antifungals as repurposed host-directed anti-infectives for the therapeutic intervention to control viral infections.
Identifiants
pubmed: 35215323
pii: ph15020212
doi: 10.3390/ph15020212
pmc: PMC8878022
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC1009 "Breaking Barriers", CRC 1348 "Dynamic Cellular Interfaces"
Organisme : Interdisciplinary Center for Clinical Research of the Münster Medical School
ID : Re2/022/20
Organisme : Innovative Medizinische Forschung (IMF) of the Münster Medical School
ID : SC121912
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