Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer.
DNA methylation
cholesterol
diet
epigenetics
fatty acid
histone modifications
lipid metabolism
predictive biomarkers
prostate cancer
therapeutic vulnerabilities
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
18 Feb 2022
18 Feb 2022
Historique:
received:
16
12
2021
revised:
27
01
2022
accepted:
14
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
3
3
2022
Statut:
epublish
Résumé
Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men in the Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite the incorporation of new therapeutic strategies, metastatic PCa remains incurable mainly due to disease heterogeneity and the development of resistance to therapy. The mechanisms underlying PCa progression and therapy resistance are multiple and include metabolic reprogramming, especially in relation to lipid metabolism, as well as epigenetic remodelling, both of which enable cancer cells to adapt to dynamic changes in the tumour. Interestingly, metabolism and epigenetics are interconnected. Metabolism can regulate epigenetics through the direct influence of metabolites on epigenetic processes, while epigenetics can control metabolism by directly or indirectly regulating the expression of metabolic genes. Moreover, epidemiological studies suggest an association between a high-fat diet, which can alter the availability of metabolites, and PCa progression. Here, we review the alterations of lipid metabolism and epigenetics in PCa, before focusing on the mechanisms that connect them. We also discuss the influence of diet in this scenario. This information may help to identify prognostic and predictive biomarkers as well as targetable vulnerabilities.
Identifiants
pubmed: 35215499
pii: nu14040851
doi: 10.3390/nu14040851
pmc: PMC8874497
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : CM20/00028
Organisme : Instituto de Salud Carlos III
ID : PI18/00654
Organisme : Spanish Society of Medical Oncology
ID : 2021 D. Jesús Angel Sánchez Castillo for Research Projects
Références
J Biol Chem. 1956 Sep;222(1):193-214
pubmed: 13366993
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Curr Opin Cell Biol. 2015 Apr;33:125-31
pubmed: 25703630
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1166-1177
pubmed: 28627435
N Engl J Med. 2013 Jan 10;368(2):138-48
pubmed: 23228172
Signal Transduct Target Ther. 2020 Oct 7;5(1):227
pubmed: 33028824
J Steroid Biochem Mol Biol. 2014 Sep;143:277-84
pubmed: 24787657
Brief Funct Genomic Proteomic. 2006 Sep;5(3):209-21
pubmed: 16877467
Trends Cell Biol. 2021 Dec;31(12):994-1006
pubmed: 34281779
Front Oncol. 2020 Oct 09;10:580617
pubmed: 33163409
Cancer Lett. 2020 Mar 31;473:176-185
pubmed: 31923436
Mol Cell Proteomics. 2016 Jan;15(1):154-63
pubmed: 26545398
J Steroid Biochem Mol Biol. 1998 Apr;65(1-6):191-8
pubmed: 9699873
Nat Rev Cancer. 2011 Sep 23;11(10):726-34
pubmed: 21941284
Cancer Res. 1987 Oct 15;47(20):5274-6
pubmed: 2443238
Proc Natl Acad Sci U S A. 1985 Jan;82(1):4-8
pubmed: 3881757
Nat Rev Genet. 2014 Feb;15(2):93-106
pubmed: 24366184
Prog Mol Biol Transl Sci. 2018;154:71-104
pubmed: 29413178
Cell. 2019 Jan 24;176(3):564-580.e19
pubmed: 30580964
J Steroid Biochem Mol Biol. 2004 Nov;92(4):273-9
pubmed: 15663990
Prostate. 2018 Sep;78(12):889-895
pubmed: 29707790
Cancer Lett. 2002 Dec 10;187(1-2):1-7
pubmed: 12359344
Cancer. 2004 Feb 15;100(4):826-33
pubmed: 14770441
Nat Rev Endocrinol. 2015 Oct;11(10):592-605
pubmed: 26260145
Sci Rep. 2019 Feb 28;9(1):3035
pubmed: 30816200
Biochem Biophys Res Commun. 2003 Mar 21;302(4):898-903
pubmed: 12646257
Oncogene. 2003 May 8;22(18):2739-49
pubmed: 12743598
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2881-2889
pubmed: 29857051
Cell Metab. 2016 Jan 12;23(1):27-47
pubmed: 26771115
Nat Rev Genet. 2016 May;17(5):284-99
pubmed: 26972587
Oncotarget. 2016 Jul 12;7(28):43713-43730
pubmed: 27248322
Trends Biochem Sci. 2018 Jan;43(1):61-74
pubmed: 29174173
Nat Genet. 2018 Feb;50(2):219-228
pubmed: 29335542
Cell. 2014 Dec 4;159(6):1253-62
pubmed: 25480291
BMC Cancer. 2017 Sep 6;17(1):631
pubmed: 28877685
World J Oncol. 2019 Apr;10(2):63-89
pubmed: 31068988
Nature. 2019 Feb;566(7744):403-406
pubmed: 30728499
Sci Transl Med. 2019 Feb 6;11(478):
pubmed: 30728288
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Prostate. 2008 Mar 1;68(4):345-53
pubmed: 18188867
N Engl J Med. 2019 Jul 11;381(2):121-131
pubmed: 31157964
Prostate Cancer Prostatic Dis. 2015 Mar;18(1):1-12
pubmed: 25384337
Mol Imaging Biol. 2010 Apr;12(2):210-7
pubmed: 19543774
Nat Rev Cancer. 2016 Nov;16(11):732-749
pubmed: 27658529
Front Genet. 2019 Nov 14;10:1150
pubmed: 31803237
Mol Cell. 2015 Apr 16;58(2):203-15
pubmed: 25818647
Science. 2011 Nov 11;334(6057):806-9
pubmed: 22076378
Prostate Cancer Prostatic Dis. 2006;9(3):230-4
pubmed: 16683009
Sci Rep. 2017 Oct 12;7(1):13021
pubmed: 29026202
N Engl J Med. 2018 Jun 28;378(26):2465-2474
pubmed: 29949494
N Engl J Med. 2018 Feb 15;378(7):645-657
pubmed: 29412780
Mol Cell. 2005 Sep 2;19(5):631-42
pubmed: 16137620
Clin Cancer Res. 2021 Sep 15;27(18):5004-5011
pubmed: 34011557
Prostate. 1989;15(4):335-42
pubmed: 2594584
Lancet. 2021 Sep 18;398(10305):1075-1090
pubmed: 34370973
Cell Death Discov. 2019 Sep 30;5:139
pubmed: 31583122
Cancers (Basel). 2021 Oct 01;13(19):
pubmed: 34638444
Cell Metab. 2014 Mar 4;19(3):393-406
pubmed: 24606897
Cancers (Basel). 2021 Jul 02;13(13):
pubmed: 34283056
Cancer Res. 2021 Jan 1;81(1):50-63
pubmed: 33115805
J Cell Mol Med. 2018 Mar;22(3):1909-1922
pubmed: 29327812
BMC Urol. 2012 Mar 13;12:5
pubmed: 22413846
Int J Oncol. 2014 Jan;44(1):265-75
pubmed: 24189640
Nat Rev Mol Cell Biol. 2019 Oct;20(10):590-607
pubmed: 31399642
Eur J Cancer Prev. 2014 Mar;23(2):96-109
pubmed: 23872953
Oncogene. 2015 Sep 3;34(36):4683-91
pubmed: 25531313
Nutrients. 2014 Dec 22;6(12):6095-109
pubmed: 25533015
J Urol. 1998 Apr;159(4):1271-5
pubmed: 9507851
Clin Nucl Med. 2012 Jul;37(7):637-43
pubmed: 22691503
Mol Cell. 2006 Jul 21;23(2):207-17
pubmed: 16857587
Methods. 2005 Aug;36(4):321-31
pubmed: 16085424
Nat Metab. 2020 Feb;2(2):132-141
pubmed: 32694690
Oncotarget. 2015 Dec 1;6(38):41018-32
pubmed: 26512780
Int J Cancer. 2000 Oct 15;88(2):245-51
pubmed: 11004676
Prostate Cancer Prostatic Dis. 2020 Dec;23(4):630-637
pubmed: 32203069
Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):431-8
pubmed: 19299327
Mol Cell. 2016 Apr 21;62(2):194-206
pubmed: 27105115
BMC Clin Pathol. 2014 Jan 14;14(1):3
pubmed: 24422874
Endocrinology. 2009 Sep;150(9):3991-4002
pubmed: 19520778
Scand J Urol. 2018 Jun;52(3):200-205
pubmed: 29475387
Transl Androl Urol. 2013 Sep;2(3):212-227
pubmed: 25379460
Nat Genet. 2020 Aug;52(8):778-789
pubmed: 32661416
Nat Rev Urol. 2021 Oct;18(10):581-596
pubmed: 34290447
Molecules. 2018 Aug 03;23(8):
pubmed: 30081476
Oncotarget. 2017 Oct 31;9(2):1494-1504
pubmed: 29416709
Nat Rev Genet. 2016 Aug;17(8):487-500
pubmed: 27346641
Endocr Relat Cancer. 2006 Jun;13(2):357-77
pubmed: 16728568
Mol Cell. 2017 Apr 20;66(2):180-193.e8
pubmed: 28366644
Cancer Res. 2016 Oct 1;76(19):5634-5646
pubmed: 27457520
Biochem Biophys Res Commun. 2002 Aug 23;296(3):580-3
pubmed: 12176020
Nat Genet. 2018 Feb;50(2):206-218
pubmed: 29335545
Exp Mol Med. 2020 Dec;52(12):2005-2019
pubmed: 33311704
Cancer Discov. 2021 Sep;11(9):2316-2333
pubmed: 33893149
Reprod Biol Endocrinol. 2015 Aug 07;13:88
pubmed: 26251134
Chem Biol. 2011 Jul 29;18(7):846-56
pubmed: 21802006
BJU Int. 2012 Aug;110(4):492-8
pubmed: 22094083
Trends Endocrinol Metab. 2018 Sep;29(9):626-637
pubmed: 30001904
Cell Res. 2011 Mar;21(3):381-95
pubmed: 21321607
JAMA Intern Med. 2013 Jul 22;173(14):1318-26
pubmed: 23752662
Eur Urol. 2018 Jun;73(6):847-855
pubmed: 29475737
Curr Opin Chem Biol. 2019 Aug;51:18-29
pubmed: 30875552
Cell. 2010 Jan 8;140(1):49-61
pubmed: 20079333
Hepatology. 2007 Sep;46(3):885-97
pubmed: 17654698
Mol Cell. 2011 May 20;42(4):426-37
pubmed: 21596309
Nature. 2002 Oct 10;419(6907):624-9
pubmed: 12374981
Cancer Res. 2009 Oct 15;69(20):8133-40
pubmed: 19826053
N Engl J Med. 2019 Jul 4;381(1):13-24
pubmed: 31150574
Annu Rev Physiol. 2019 Feb 10;81:165-188
pubmed: 30379616
Prostate. 2008 Feb 15;68(3):321-35
pubmed: 18175332
Br J Cancer. 2008 Feb 12;98(3):604-10
pubmed: 18212746
J Clin Med. 2019 Apr 30;8(5):
pubmed: 31052319
Cell Rep. 2015 Dec 15;13(10):2135-46
pubmed: 26628371
Dev Cell. 2010 Nov 16;19(5):698-711
pubmed: 21074720
Nat Metab. 2019 Jan;1(1):70-85
pubmed: 31198906
N Engl J Med. 2011 May 26;364(21):1995-2005
pubmed: 21612468
Nature. 2021 Nov;599(7885):485-490
pubmed: 34759321
Cancer Res. 2017 Apr 1;77(7):1662-1673
pubmed: 28130224
N Engl J Med. 2014 Jul 31;371(5):424-33
pubmed: 24881730
Int J Cancer. 2002 Feb 10;97(5):621-5
pubmed: 11807787
Sci Adv. 2021 Feb 10;7(7):
pubmed: 33568479
Cell Metab. 2019 Apr 2;29(4):856-870.e7
pubmed: 30686744
Chem Rev. 2015 Mar 25;115(6):2350-75
pubmed: 25804908
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Prostate. 2010 Jan 1;70(1):61-9
pubmed: 19739128
J Biol Chem. 2013 Oct 25;288(43):31350-6
pubmed: 24052263
Elife. 2020 Jul 20;9:
pubmed: 32686647
Epigenetics Chromatin. 2018 May 30;11(1):25
pubmed: 29848354
Mol Cell. 2016 Jun 2;62(5):695-711
pubmed: 27259202
Br J Cancer. 2020 Jan;122(1):4-22
pubmed: 31819192
Curr Mol Biol Rep. 2018;4(2):101-115
pubmed: 29888169
Prostate. 2020 Jan;80(1):88-98
pubmed: 31661167
Carcinogenesis. 2017 Aug 1;38(8):806-811
pubmed: 28595267
Annu Rev Cancer Biol. 2021 Mar;5(1):235-257
pubmed: 34109280
Curr Opin Genet Dev. 2014 Apr;25:85-92
pubmed: 24614011
Nat Commun. 2018 Oct 4;9(1):4080
pubmed: 30287808
Biochim Biophys Acta Gene Regul Mech. 2019 Aug;1862(8):834-845
pubmed: 31154107
Lancet. 2010 Oct 2;376(9747):1147-54
pubmed: 20888992
Cancer Discov. 2011 Nov;1(6):487-95
pubmed: 22389870
Ann Oncol. 2012 Jul;23(7):1665-71
pubmed: 22228452
J Cell Physiol. 2019 Jan 22;:
pubmed: 30667054
Toxicol In Vitro. 2013 Aug;27(5):1489-95
pubmed: 23524101
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4328-4336
pubmed: 32029582
J Biol Chem. 2020 Dec 25;295(52):18355-18366
pubmed: 33122195
Annu Rev Biochem. 2012;81:687-714
pubmed: 22524315
Int J Mol Sci. 2020 Feb 20;21(4):
pubmed: 32093338
Genes Cancer. 2013 Mar;4(3-4):148-63
pubmed: 24020006
Am J Cancer Res. 2012;2(5):589-97
pubmed: 22957310
Future Oncol. 2017 Feb;13(3):285-293
pubmed: 27624840
N Engl J Med. 2018 Apr 12;378(15):1408-1418
pubmed: 29420164
BMC Cancer. 2017 Apr 12;17(1):261
pubmed: 28403887
Nat Rev Genet. 2006 Jan;7(1):21-33
pubmed: 16369569
Nucl Med Commun. 2014 Mar;35(3):221-30
pubmed: 24240194
Nat Cell Biol. 2007 Mar;9(3):347-53
pubmed: 17277772
Nat Rev Mol Cell Biol. 2012 Mar 07;13(4):225-238
pubmed: 22395773
Cell Metab. 2014 Aug 5;20(2):306-319
pubmed: 24998913
Oncogene. 2020 Oct;39(42):6556-6571
pubmed: 32917955
Front Oncol. 2021 Jul 27;11:719865
pubmed: 34386430
Mol Cancer Ther. 2014 Oct;13(10):2361-71
pubmed: 25122071
Nat Rev Urol. 2020 Apr;17(4):214-231
pubmed: 32112053
Trends Endocrinol Metab. 2013 Jul;24(7):342-50
pubmed: 23415156
Science. 2009 May 22;324(5930):1076-80
pubmed: 19461003
J Hum Nutr Diet. 2009 Jun;22(3):187-99; quiz 200-2
pubmed: 19344379
Nat Rev Urol. 2010 Dec;7(12):668-80
pubmed: 21060342
Oncotarget. 2016 Mar 22;7(12):15135-49
pubmed: 26934656
Clin Biochem. 2012 Dec;45(18):1548-53
pubmed: 22921309
Nutr Rev. 2021 Jan 9;79(2):235-246
pubmed: 32403131
Cancer Res. 2011 Oct 15;71(20):6503-13
pubmed: 21868758
Nat Med. 2016 Mar;22(3):298-305
pubmed: 26855148
Cancer Res. 2013 Feb 1;73(3):1211-8
pubmed: 23233737
Gene. 2018 Dec 15;678:395-406
pubmed: 29969695
Prostate. 2007 Sep 1;67(12):1330-8
pubmed: 17626249
Endocr Rev. 2000 Dec;21(6):697-738
pubmed: 11133069
Curr Opin Pharmacol. 2012 Dec;12(6):751-9
pubmed: 22824430
Genes (Basel). 2015 Jun 12;6(2):299-324
pubmed: 26075616
Cold Spring Harb Perspect Med. 2019 Apr 1;9(4):
pubmed: 29959132
Eur Urol. 2015 May;67(5):825-36
pubmed: 25097095
Nature. 2017 Jan 5;541(7635):41-45
pubmed: 27974793
EMBO Rep. 2006 Jan;7(1):106-13
pubmed: 16239926
Int J Oncol. 2005 Apr;26(4):863-71
pubmed: 15753979
Clin Epigenetics. 2016 Sep 15;8:98
pubmed: 27651838
Front Cell Dev Biol. 2020 May 15;8:259
pubmed: 32500071
Anticancer Res. 2007 Sep-Oct;27(5A):3285-92
pubmed: 17970072
Nat Rev Cancer. 2011 May;11(5):325-37
pubmed: 21508971
EBioMedicine. 2021 Jun;68:103432
pubmed: 34144486
Cancer Cell Int. 2019 Mar 5;19:51
pubmed: 30872976
Nature. 2013 Apr 4;496(7443):110-3
pubmed: 23552949
Oncogenesis. 2016 Feb 15;5:e195
pubmed: 26878389
Nature. 2000 Jan 6;403(6765):41-5
pubmed: 10638745
Transl Androl Urol. 2021 Feb;10(2):900-914
pubmed: 33718091
Eur Urol. 2011 Oct;60(4):753-66
pubmed: 21719191
EClinicalMedicine. 2021 Mar 30;34:100797
pubmed: 33870151
Cancer Prev Res (Phila). 2011 Apr;4(4):486-501
pubmed: 21233290
Cell. 2015 Nov 5;163(4):1011-25
pubmed: 26544944
Cell. 2011 Sep 16;146(6):1016-28
pubmed: 21925322
Cancer Lett. 2018 Oct 28;435:92-100
pubmed: 30102953
J Endocrinol. 2004 Sep;182(3):377-89
pubmed: 15350180
Clin Cancer Res. 2009 Jun 1;15(11):3881-8
pubmed: 19470736
Genes Dev. 2008 Jul 1;22(13):1753-7
pubmed: 18550784
Genes Chromosomes Cancer. 2002 Sep;35(1):58-65
pubmed: 12203790
Nat Commun. 2019 Sep 25;10(1):4358
pubmed: 31554818
Obes Res. 2004 Dec;12(12):1930-5
pubmed: 15687393
Eur J Nucl Med Mol Imaging. 2011 Nov;38(11):1985-9
pubmed: 21732105
Nat Rev Cancer. 2011 Nov 17;11(12):835-48
pubmed: 22089420
J Natl Cancer Inst. 1993 Oct 6;85(19):1571-9
pubmed: 8105097
Int J Urol. 2021 Feb;28(2):140-149
pubmed: 33111429
Mol Cancer Ther. 2010 Jun;9(6):1740-54
pubmed: 20530718
Nat Rev Genet. 2013 Mar;14(3):204-20
pubmed: 23400093
Cell. 2016 Jun 2;165(6):1332-1345
pubmed: 27259147
Clin Cancer Res. 2001 Jun;7(6):1706-15
pubmed: 11410510
Eur Urol. 2007 Aug;52(2):331-43
pubmed: 17507151
N Engl J Med. 2012 Sep 27;367(13):1187-97
pubmed: 22894553
Cell Metab. 2008 Sep;8(3):224-36
pubmed: 18762023
Am J Pathol. 2010 Dec;177(6):3180-91
pubmed: 21088217
Cancer Res. 2004 Mar 15;64(6):2212-21
pubmed: 15026365
Genome Res. 2011 Jul;21(7):1028-41
pubmed: 21724842
Eur Urol Focus. 2019 Mar;5(2):147-154
pubmed: 30772358
Nat Rev Genet. 2015 Feb;16(2):71-84
pubmed: 25554358
Front Genet. 2019 Jul 19;10:680
pubmed: 31379931
Cancer Invest. 2012 Feb;30(2):92-7
pubmed: 22149091
Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2611-22
pubmed: 20841388
N Engl J Med. 2019 Mar 28;380(13):1235-1246
pubmed: 30763142
Nat Med. 2016 Feb;22(2):128-34
pubmed: 26845405
J Lipid Res. 2013 Oct;54(10):2745-53
pubmed: 23881913
Arch Biochem Biophys. 2016 Dec 1;611:100-112
pubmed: 27132038
Am J Pathol. 2014 Aug;184(8):2156-62
pubmed: 24907642
Mol Endocrinol. 2006 Oct;20(10):2265-77
pubmed: 16455816
Science. 2001 Aug 10;293(5532):1103-5
pubmed: 11498582
Oncotarget. 2016 Mar 1;7(9):10536-46
pubmed: 26859682
Cell Stem Cell. 2015 Feb 5;16(2):171-83
pubmed: 25600643
Mol Cancer Res. 2019 May;17(5):1166-1179
pubmed: 30808729
Nat Commun. 2016 Jun 30;7:11960
pubmed: 27357947
J Clin Invest. 2001 Sep;108(6):785-91
pubmed: 11560944
Int J Oncol. 2008 Aug;33(2):381-8
pubmed: 18636160
J Appl Physiol (1985). 2010 Jul;109(1):243-51
pubmed: 20378707
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):631-640
pubmed: 30578319
N Engl J Med. 2017 Jul 27;377(4):352-360
pubmed: 28578607
Diabetes Obes Metab. 2002 May;4(3):209-13
pubmed: 12047400
Methods Mol Biol. 2015;1238:217-34
pubmed: 25421662
Nat Commun. 2021 Apr 23;12(1):2398
pubmed: 33893278
Genes Dev. 2002 Jan 1;16(1):6-21
pubmed: 11782440
J Exp Clin Cancer Res. 2019 Feb 4;38(1):52
pubmed: 30717785
Lab Invest. 2000 Dec;80(12):1789-96
pubmed: 11140692
Endocr Relat Cancer. 2020 Feb;27(2):R35-R50
pubmed: 31804971
Nutrients. 2021 Feb 03;13(2):
pubmed: 33546190
Nat Rev Mol Cell Biol. 2017 Feb;18(2):90-101
pubmed: 27924077
Curr Opin Clin Nutr Metab Care. 2019 Sep;22(5):347-354
pubmed: 31365463
ACS Chem Biol. 2015 Jan 16;10(1):146-56
pubmed: 25325435