Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel Na

Binding Sites / physiology Cell Line HEK293 Cells Humans Ion Channel Gating / drug effects Mouth / metabolism NAV1.5 Voltage-Gated Sodium Channel / metabolism Neurotoxins / pharmacology Sodium / metabolism Veratridine / pharmacology
Rosetta SCN5A cardiac sodium channels electrophysiology molecular docking site-directed mutagenesis toxins veratridine voltage-gated sodium channels

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
17 Feb 2022
Historique:
received: 31 12 2021
revised: 07 02 2022
accepted: 15 02 2022
entrez: 26 2 2022
pubmed: 27 2 2022
medline: 24 3 2022
Statut: epublish

Résumé

The cardiac sodium ion channel (Na

Identifiants

DOI: 10.3390/ijms23042225 PMID: 35216338 PMC: PMC8878851
pubmed: 35216338
pii: ijms23042225
doi: 10.3390/ijms23042225
pmc: PMC8878851
pii:
doi:

Substances chimiques

NAV1.5 Voltage-Gated Sodium Channel 0
Neurotoxins 0
SCN5A protein, human 0
Veratridine 71-62-5
Sodium 9NEZ333N27

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R56 AI110750
Pays : United States
Organisme : NHGRI NIH HHS
ID : K99 HG010904
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL135442
Pays : United States
Organisme : NIH HHS
ID : S10 OD025281
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144131
Pays : United States
Organisme : NIH HHS
ID : S10 OD023680
Pays : United States

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Auteurs

Alican Gulsevin (A)

Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37212, USA.
ORCID: 0000-0002-8724-5777

Andrew M Glazer (AM)

Department of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
ORCID: 0000-0002-3938-4713

Tiffany Shields (T)

Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37212, USA.
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Brett M Kroncke (BM)

Department of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Dan M Roden (DM)

Department of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
ORCID: 0000-0002-6302-0389

Jens Meiler (J)

Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37212, USA.
Institute for Drug Discovery, Leipzig University Medical School, 04103 Leipzig, Germany.
ORCID: 0000-0001-8945-193X

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Ouverture et fermeture des portes des canaux ioniques › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Système stomatognathique › Bouche › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.5 › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Neurotoxines › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Veratridine Can Bind to a Site at the Mouth of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Cévanes › Vératridine › Veratridine Can Bind to a Site at the Mouth of...