Engineered Zinc Finger Protein Targeting 2LTR Inhibits HIV Integration in Hematopoietic Stem and Progenitor Cell-Derived Macrophages: In Vitro Study.
anti-HIV-1 scaffold
gene therapy
hematopoietic stem/progenitor cell
zinc finger domain
zinc finger protein
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Feb 2022
19 Feb 2022
Historique:
received:
12
01
2022
revised:
15
02
2022
accepted:
16
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
23
3
2022
Statut:
epublish
Résumé
Human hematopoietic stem/progenitor cell (HSPC)-based gene therapy is a promising direction for curing HIV-1-infected individuals. The zinc finger protein (2LTRZFP) designed to target the 2-LTR-circle junction of HIV-1 cDNA was previously reported as an intracellular antiviral molecular scaffold that prevents HIV integration. Here, we elucidate the efficacy and safety of using 2LTRZFP in human CD34
Identifiants
pubmed: 35216446
pii: ijms23042331
doi: 10.3390/ijms23042331
pmc: PMC8875109
pii:
doi:
Substances chimiques
Antigens, CD34
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Distinguished Research Professor Grant of the National Research Council of Thailand
ID : NRCT 808/2563
Organisme : the Office of National Higher Education Science Research and Innovation Policy Council (NXPO), Thailand, through Program Management Unit for Competitiveness (PMU C)
ID : C10F630145
Organisme : the Program Management Unit for Human Resources and Institutional Development, Research and Innovation
ID : B05F630102
Organisme : the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation
ID : RGNS 63-067
Organisme : Fundamental Fund 2022, Chiang Mai University
Organisme : CMU Junior Research Fellowship Program
Organisme : AMS Research Grant of Faculty of Associated Medical Sciences, Chiang Mai University
Organisme : King Mongkut's Institute of Technology Ladkrabang
ID : 2563-0216006
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