Accurate Measurement and Harmonized Reference Ranges for Total and Free Testosterone Levels.

Ensemble ALlstery Model Equilibrium dialysis Free testosterone Harmonized reference ranges for testosterone Hypogonadism Testosterone assays Testosterone deficiency Total testosterone

Journal

Endocrinology and metabolism clinics of North America
ISSN: 1558-4410
Titre abrégé: Endocrinol Metab Clin North Am
Pays: United States
ID NLM: 8800104

Informations de publication

Date de publication:
03 2022
Historique:
entrez: 26 2 2022
pubmed: 27 2 2022
medline: 1 4 2022
Statut: ppublish

Résumé

Diagnosing testosterone deficiency requires accurate and precise measurement of total testosterone levels by an accurate method, such as liquid chromatography-tandem mass spectrometry in a laboratory certified by an accuracy-based program (eg, Centers for Disease Control and Prevention's Hormone Standardization (HoST) Program), and, if needed, free testosterone level. Free testosterone level should ideally be measured by equilibrium dialysis method. Testosterone levels should be measured in 2 or more fasting samples obtained in the morning. Harmonized reference ranges for total testosterone can be applied to laboratories that certified by the HoST Program.

Identifiants

pubmed: 35216721
pii: S0889-8529(21)00102-X
doi: 10.1016/j.ecl.2021.11.002
pii:
doi:

Substances chimiques

Testosterone 3XMK78S47O

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

63-75

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Ravi Jasuja (R)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

Karol M Pencina (KM)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

Liming Peng (L)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

Shalender Bhasin (S)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. Electronic address: sbhasin@bwh.harvard.edu.

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Classifications MeSH