Single-cell atlases: shared and tissue-specific cell types across human organs.
Journal
Nature reviews. Genetics
ISSN: 1471-0064
Titre abrégé: Nat Rev Genet
Pays: England
ID NLM: 100962779
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
accepted:
17
01
2022
pubmed:
27
2
2022
medline:
23
6
2022
entrez:
26
2
2022
Statut:
ppublish
Résumé
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology advances are bringing increasing depth and resolution to maps of human organs and tissues, as well as our understanding of individual human cell types. Commonalities as well as tissue-specific features of primary and supportive cell types across human organs are beginning to emerge from these human tissue maps. In this Review, we highlight key biological insights obtained from cross-tissue studies into epithelial, fibroblast, vascular and immune cells based on single-cell gene expression data in humans and contrast it with mechanisms reported in mice.
Identifiants
pubmed: 35217821
doi: 10.1038/s41576-022-00449-w
pii: 10.1038/s41576-022-00449-w
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
395-410Informations de copyright
© 2022. Springer Nature Limited.
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