Interaction of childhood abuse and depressive symptoms on cortical thickness: a general population study.
Childhood abuse
Cortical thickness
Depressive symptoms
Resilience
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
16
08
2021
accepted:
01
02
2022
pubmed:
27
2
2022
medline:
16
11
2022
entrez:
26
2
2022
Statut:
ppublish
Résumé
Childhood abuse was inconsistently related to whole-brain cortical thickness in former studies. However, both childhood abuse and cortical thickness have been associated with depressive symptoms. We hypothesised that childhood abuse moderates the association between depressive symptoms and cortical thickness. In 1551 individuals of the general population, associations between whole-brain cortical thickness and the interaction of childhood abuse (emotional, physical, and sexual) and depressive symptoms were analysed using an ANCOVA. Linear regression analyses were used to estimate the same effect on the cortical thickness of 34 separate regions (Desikan-Killiany-atlas). A significant interaction effect of childhood abuse and depressive symptoms was observed for whole-brain cortical thickness (F(2, 1534) = 5.28, p = 0.007). A thinner cortex was associated with depressive symptoms in abused (t value = 2.78, p = 0.025) but not in non-abused participants (t value = - 1.50, p = 0.224). Focussing on non-depressed participants, a thicker whole-brain cortex was found in abused compared to non-abused participants (t value = - 2.79, p = 0.025). Similar interaction effects were observed in 12 out of 34 cortical regions. Our results suggest that childhood abuse is associated with reduced cortical thickness in subjects with depressive symptoms. In abused subjects without depressive symptoms, larger cortical thickness might act compensatory and thus reflect resilience against depressive symptoms.
Identifiants
pubmed: 35217912
doi: 10.1007/s00406-022-01387-8
pii: 10.1007/s00406-022-01387-8
pmc: PMC9653317
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1523-1534Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 01ZZ9603
Organisme : Bundesministerium für Bildung und Forschung
ID : 01ZZ0103
Organisme : Bundesministerium für Bildung und Forschung
ID : 01ZZ0403
Organisme : Ministerium für Wissenschaft, Forschung und Kultur
ID : 01ZZ9603
Organisme : Ministerium für Wissenschaft, Forschung und Kultur
ID : 01ZZ0103
Organisme : Ministerium für Wissenschaft, Forschung und Kultur
ID : 01ZZ0403
Organisme : Siemens Healthineers
ID : 01ZZ9603
Organisme : Siemens Healthineers
ID : 01ZZ0103
Organisme : Siemens Healthineers
ID : 01ZZ0403
Organisme : National Institute of Health (NIH) grant
ID : AG059421
Organisme : EU-JPND Funding for BRIDGET
ID : FKZ:01ED1615
Informations de copyright
© 2022. The Author(s).
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