Effect of oligosaccharides on the antioxidant, lipid and inflammatory profiles of rats with streptozotocin-induced diabetes mellitus.
antioxidant protection
diabetes mellitus
galacto-oligosaccharides
rats
xylo-oligosaccharides
Journal
Zeitschrift fur Naturforschung. C, Journal of biosciences
ISSN: 1865-7125
Titre abrégé: Z Naturforsch C J Biosci
Pays: Germany
ID NLM: 8912155
Informations de publication
Date de publication:
27 Sep 2022
27 Sep 2022
Historique:
received:
09
08
2021
accepted:
04
02
2022
pubmed:
27
2
2022
medline:
2
9
2022
entrez:
26
2
2022
Statut:
epublish
Résumé
Prebiotics, gut microbiota-fermentable substances, delay the development of type I diabetes. In the present study, we investigated the effect of two prebiotics (galacto-oligosaccharides and xylo-oligosaccharides) on the antioxidant protection, lipid profile, and inflammatory activity of rats with streptozotocin-induced diabetes. The following markers were studied - malondialdehyde, 8-hydroxy-2'-deoxyguanosine, ferric reducing ability of plasma (FRAP), triacylglycerols, total cholesterol (TC), high-density lipoproteins, C-reactive protein (CRP), and interleukin-6. Diabetes was induced in male Wistar experimental rats by streptozotocin injection, while the non-diabetic controls were injected with saline. Afterward the oligosaccharides were administered orally to the experimental animals. The blood collected following the decapitation was analyzed by ELISA. A modified protocol was used only for measuring the FRAP values. The galacto-oligosaccharides and xylo-oligosaccharides lowered the malondialdehyde levels in the diabetic rats (
Identifiants
pubmed: 35218687
pii: znc-2021-0215
doi: 10.1515/znc-2021-0215
doi:
Substances chimiques
Antioxidants
0
Blood Glucose
0
Interleukin-6
0
Oligosaccharides
0
Triglycerides
0
Malondialdehyde
4Y8F71G49Q
Streptozocin
5W494URQ81
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-386Informations de copyright
© 2022 Krasimir O. Boyanov et al., published by De Gruyter, Berlin/Boston.
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