Bovine oocyte exposure to perfluorohexane sulfonate (PFHxS) induces phenotypic, transcriptomic, and DNA methylation changes in resulting embryos in vitro.

Animals Blastocyst Cattle DNA Methylation Embryonic Development Female Fluorocarbons In Vitro Oocyte Maturation Techniques Oocytes Pregnancy Transcriptome
Bovine Embryo quality Female fertility IVP Oocyte maturation PFAS Per- and polyfluoroalkyl substances Reproductive toxicity

Journal

Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591

Informations de publication

Date de publication:
04 2022
Historique:
received: 05 11 2021
revised: 16 02 2022
accepted: 22 02 2022
pubmed: 28 2 2022
medline: 6 4 2022
entrez: 27 2 2022
Statut: ppublish

Résumé

Knowledge on the effects of perfluorohexane sulfonate (PFHxS) on ovarian function is limited. In the current study, we investigated the sensitivity of oocytes to PFHxS during in vitro maturation (IVM), including consequences on embryo development at the morphological, transcriptomic, and epigenomic levels. Bovine cumulus-oocyte complexes (COCs) were exposed to PFHxS during 22 h IVM. Following fertilisation, developmental competence was recorded until day 8 of culture. Two experiments were conducted: 1) exposure of COCs to 0.01 µg mL

Identifiants

DOI: 10.1016/j.reprotox.2022.02.004 PMID: 35219833
pubmed: 35219833
pii: S0890-6238(22)00023-5
doi: 10.1016/j.reprotox.2022.02.004
pii:
doi:

Substances chimiques

Fluorocarbons 0
perflexane FX3WJ41CMX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

19-30

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Ida Hallberg (I)

Department of Clinical Sciences, Division of Reproduction, The Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden. Electronic address: ida.hallberg@slu.se.

Sara Persson (S)

Department of Clinical Sciences, Division of Reproduction, The Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden; Environmental research and monitoring, Swedish Museum of Natural History, P.O Box 50007, SE-104 05 Stockholm, Sweden. Electronic address: sara.persson@slu.se.

Matts Olovsson (M)

Department of Women´s and Children´s Health, Uppsala University, 751SE-751 85 Uppsala, Sweden and The Centre for Reproductive Biology in Uppsala, SE-752 37 Uppsala, Sweden. Electronic address: matts.olovsson@kbh.uu.se.

Mikaela Moberg (M)

Department of Clinical Sciences, Division of Reproduction, The Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden. Electronic address: mikan.moberg@hotmail.com.

Petter Ranefall (P)

Department of Information Technology, Division of Visual Information and Interaction, and SciLifeLab BioImage Informatics Facility, Uppsala University, Uppsala, Sweden. Electronic address: petter.ranefall@it.uu.se.

Denise Laskowski (D)

Department of Clinical Sciences, Division of Reproduction, The Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden. Electronic address: denise.laskowski@slu.se.

Pauliina Damdimopoulou (P)

Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, SE-141 86 Stockholm, Sweden. Electronic address: pauliina.damdimopoulou@ki.se.

Marc-Andre Sirard (MA)

Department of Animal Sciences, Laval University, Qubec G1V 0A6, QC, Canada. Electronic address: marc-andre.sirard@fsaa.ulaval.ca.

Joëlle Rüegg (J)

Department of Organismal Biology, Environmental Toxicology, The Centre for Reproductive Biology in Uppsala, SE-752 36 Uppsala, Sweden. Electronic address: joelle.ruegg@ebc.uu.se.

Ylva C B Sjunnesson (YCB)

Department of Clinical Sciences, Division of Reproduction, The Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden. Electronic address: ylva.sjunnesson@slu.se.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Structures de l'embryon › Embryon de mammifère › Blastocyste › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures fluorés › Fluorocarbones › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Techniques d'investigation › Techniques de reproduction › Techniques de reproduction assistée › Techniques de maturation in vitro des ovocytes › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Cellules › Cellules germinales › Ovocytes › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Bovine oocyte exposure to perfluorohexane...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Bovine oocyte exposure to perfluorohexane...