A feasible fluorimetric approach anchored in diaryl pyrrolone derivative for the facile analysis of milnacipran in tablets; evaluation of the method greenness.
Fluorescamine
Milnacipran
Pharmaceutical formulation
Spectrofluorimetry
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
15 May 2022
15 May 2022
Historique:
received:
20
12
2021
revised:
06
02
2022
accepted:
08
02
2022
pubmed:
28
2
2022
medline:
22
3
2022
entrez:
27
2
2022
Statut:
ppublish
Résumé
In the present work a new, feasible, and green approach was employed for the analysis of milnacipran. A drug is used in the management of depression in addition to fibromyalgia. It inhibits of the reuptake of two essential neurotransmitters serotonin and nor-adrenaline. In slightly alkaline buffer (pH 8.5) the primary amino group of milnacipran reacted with fluorescamine to give a substituted pyrrolone derivative which exhibited high fluorescence activity. The fluorescence of produced derivative was measured at (λ
Identifiants
pubmed: 35220049
pii: S1386-1425(22)00172-X
doi: 10.1016/j.saa.2022.121024
pii:
doi:
Substances chimiques
Cyclopropanes
0
Tablets
0
Fluorescamine
38183-12-9
Milnacipran
G56VK1HF36
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121024Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.