Carbon-ion Radiotherapy for Inoperable Head and Neck Bone and Soft-tissue Sarcoma: Prospective Observational Study.

Adult Aged Female Head and Neck Neoplasms / mortality Heavy Ion Radiotherapy / adverse effects Humans Male Middle Aged Osteosarcoma / mortality Progression-Free Survival Prospective Studies Radiation Dosage Sarcoma / mortality Time Factors Young Adult
Bone and soft-tissue sarcoma carbon-ion radiotherapy head and neck tumor

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 09 01 2022
revised: 20 01 2022
accepted: 26 01 2022
entrez: 27 2 2022
pubmed: 28 2 2022
medline: 8 3 2022
Statut: ppublish

Résumé

Bone and soft-tissue sarcomas of the head and neck have very poor prognoses. This prospective study aimed to investigate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for bone and soft-tissue sarcoma of the head and neck. The present study was a prospective clinical study that included 10 consecutive patients diagnosed with bone and soft-tissue sarcoma of the head and neck who were treated with C-ion RT between 2012 and 2018 at our institution. C-Ion RT consisted of 70.4 Gy (relative biological effectiveness) in 16 fractions. The 3-year local control, overall survival, and progression-free survival rates for patients overall were 72.9%, 77.8%, and 36%, respectively. The present study demonstrated the efficacy of C-ion RT for bone and soft-tissue sarcoma of the head and neck; adverse events were within the expected range.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
Bone and soft-tissue sarcomas of the head and neck have very poor prognoses. This prospective study aimed to investigate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for bone and soft-tissue sarcoma of the head and neck.
PATIENTS AND METHODS METHODS
The present study was a prospective clinical study that included 10 consecutive patients diagnosed with bone and soft-tissue sarcoma of the head and neck who were treated with C-ion RT between 2012 and 2018 at our institution. C-Ion RT consisted of 70.4 Gy (relative biological effectiveness) in 16 fractions.
RESULTS RESULTS
The 3-year local control, overall survival, and progression-free survival rates for patients overall were 72.9%, 77.8%, and 36%, respectively.
CONCLUSION CONCLUSIONS
The present study demonstrated the efficacy of C-ion RT for bone and soft-tissue sarcoma of the head and neck; adverse events were within the expected range.

Identifiants

DOI: 10.21873/anticanres.15614 PMID: 35220237
pubmed: 35220237
pii: 42/3/1439
doi: 10.21873/anticanres.15614
doi:

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

1439-1446

Informations de copyright

Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Atsushi Musha (A)

Gunma University Heavy Ion Medical Center, Maebashi, Japan; musha@gunma-u.ac.jp.
Department of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Nobuteru Kubo (N)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Hidemasa Kawamura (H)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Naoko Okano (N)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Hiro Sato (H)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Kohei Okada (K)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Naoto Osu (N)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Hikaru Yumisaki (H)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Akiko Adachi (A)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Yukihiro Takayasu (Y)

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Masato Shino (M)

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Osamu Nikkuni (O)

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Shota Ida (S)

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Katsuyuki Shirai (K)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Department of Radiology, Jichi Medical University Hospital, Tochigi, Japan.

Jun-Ichi Saitoh (JI)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.

Satoshi Yokoo (S)

Department of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Kazuaki Chikamatsu (K)

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.

Tatsuya Ohno (T)

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie par ions lourds › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Ostéosarcome › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans progression › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Dose de rayonnement › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Carbon-ion Radiotherapy for Inoperable Head...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Carbon-ion Radiotherapy for Inoperable Head...