Outcome of Ordinary Polymorphous Adenocarcinomas of the Salivary Glands in Comparison With Papillary and Cribriform Subtypes.
Adenocarcinoma
/ chemistry
Adenocarcinoma, Papillary
/ chemistry
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Child
Female
Germany
Humans
Male
Middle Aged
Mutation
Neoplasm Staging
Registries
Salivary Gland Neoplasms
/ chemistry
Sex Factors
Time Factors
Tumor Burden
Young Adult
PRKD1
Salivary gland tumor
cribriform adenocarcinoma of salivary glands
molecular diagnostics
polymorphous adenocarcinoma
polymorphous low-grade adenocarcinoma
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
20
12
2021
revised:
17
01
2022
accepted:
19
01
2022
entrez:
27
2
2022
pubmed:
28
2
2022
medline:
8
3
2022
Statut:
ppublish
Résumé
Polymorphous adenocarcinoma (PAC) is a low-grade salivary gland malignancy in contrast to variants with papillary (PAP) or cribriform (CASG) architecture and confers the second most common malignancy of minor salivary glands. Our study aimed to identify prognostic factors and to evaluate histomorphological and molecular diagnostic criteria of PACs. A series of 155 PACs, including 10 PAPs and 12 CASGs from the population-based Cancer Registry of North Rhine-Westphalia (LKR-NRW) and the Hamburg Salivary Gland Reference Centre (HRC) were analyzed. One fifth of the tumors were located in the major salivary glands and PACS/CASGS invariably lacked p40 expression. Fifty-two percent of PACs showed a PRKD1 E710D mutation. Ordinary PACs had a disease-specific 10-year survival probability of 97% compared to 90% when combining PAPs and CASGs. T-stage at diagnosis was a prognostic factor with 98% for stages T1/T2 versus 75% for T3/T4. Diagnostic algorithms for the PAC/CASG spectrum of tumors need to be improved and should include molecular markers.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Polymorphous adenocarcinoma (PAC) is a low-grade salivary gland malignancy in contrast to variants with papillary (PAP) or cribriform (CASG) architecture and confers the second most common malignancy of minor salivary glands. Our study aimed to identify prognostic factors and to evaluate histomorphological and molecular diagnostic criteria of PACs.
PATIENTS AND METHODS
METHODS
A series of 155 PACs, including 10 PAPs and 12 CASGs from the population-based Cancer Registry of North Rhine-Westphalia (LKR-NRW) and the Hamburg Salivary Gland Reference Centre (HRC) were analyzed.
RESULTS
RESULTS
One fifth of the tumors were located in the major salivary glands and PACS/CASGS invariably lacked p40 expression. Fifty-two percent of PACs showed a PRKD1 E710D mutation. Ordinary PACs had a disease-specific 10-year survival probability of 97% compared to 90% when combining PAPs and CASGs. T-stage at diagnosis was a prognostic factor with 98% for stages T1/T2 versus 75% for T3/T4.
CONCLUSION
CONCLUSIONS
Diagnostic algorithms for the PAC/CASG spectrum of tumors need to be improved and should include molecular markers.
Identifiants
pubmed: 35220239
pii: 42/3/1455
doi: 10.21873/anticanres.15616
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1455-1463Informations de copyright
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.