Effect of hyperhomocysteinemia on rat cardiac sarcoplasmic reticulum.
Ca2+-ATPase
Heart
Homocysteine
Protein expression
Sarcoplasmic reticulum
Journal
Molecular and cellular biochemistry
ISSN: 1573-4919
Titre abrégé: Mol Cell Biochem
Pays: Netherlands
ID NLM: 0364456
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
30
11
2021
accepted:
16
02
2022
pubmed:
28
2
2022
medline:
12
4
2022
entrez:
27
2
2022
Statut:
ppublish
Résumé
Increased concentration of plasma homocysteine (Hcy) is an independent risk factor of cardiovascular disease, yet the mechanism by which hyperhomocysteinemia (HHcy) causes cardiac dysfunction is largely unknown. The aim of present study was to investigate the contribution of sarcoplasmic reticulum to impaired cardiac contractile function in HHCy. HHcy-induced by subcutaneous injection of Hcy (0.45 μmol/g of body weight) twice a day for a period of 2 weeks resulted in significant decrease in developed left ventricular pressure and maximum rate of ventricular relaxation. Our results show that abundances of SR Ca
Identifiants
pubmed: 35220548
doi: 10.1007/s11010-022-04399-z
pii: 10.1007/s11010-022-04399-z
doi:
Substances chimiques
Calcium-Binding Proteins
0
Calsequestrin
0
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1621-1628Subventions
Organisme : Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
ID : 1/0004/19
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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