Challenges to, and prospects for, reverse engineering the gastrointestinal tract using organoids.
co-culture
gastrointestinal tract
multiregion organoids
organoid fusion
organoid-on-a-chip
organoids
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
19
10
2021
revised:
09
01
2022
accepted:
10
01
2022
pubmed:
1
3
2022
medline:
19
7
2022
entrez:
28
2
2022
Statut:
ppublish
Résumé
For over a decade, organoids mimicking the development, physiology, and disease of the digestive system have been a topic of broad interest and intense study. Establishing organoid models that recapitulate all distinct regions of the gastrointestinal tract (GIT) has proven challenging since each tissue surrogate requires tailor-made modifications of the original protocol to generate intestinal organoids. In this review, we discuss the challenges and current advances of the GIT organoid models. Moreover, we envision the next-generation GIT organoids as integrated organoid models, able to recapitulate structural and functional characteristics of multiple regions of the digestive tube in a single in vitro model. We discuss these new trends and provide an outlook for the future of GIT in vitro models.
Identifiants
pubmed: 35221125
pii: S0167-7799(22)00006-3
doi: 10.1016/j.tibtech.2022.01.006
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
932-944Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.