Porencephaly with an optic organ abnormality in a beagle dog.
TOYO beagle
optic nerve hypoplasia
porencephaly
Journal
Journal of toxicologic pathology
ISSN: 0914-9198
Titre abrégé: J Toxicol Pathol
Pays: Japan
ID NLM: 9306408
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
16
06
2021
accepted:
28
09
2021
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
1
3
2022
Statut:
ppublish
Résumé
A female TOYO beagle dog showed porencephaly and visual organ abnormalities. At necropsy, there was a cavity filled with cerebrospinal fluid in the right cerebral hemisphere and an adhesion area between the cerebral cortex and the skull, which was partially thickened. Additionally, the right optic nerve showed a slight decrease in diameter. Histopathological examination revealed increased glial fibers and collagen fibers, hemosiderin deposition, and an increased number of microglia in the adhesion area, along with a marked reduction of the cerebral parenchyma. In the right eyeball, the retina and optic nerve showed focal atrophy in the nerve fiber layer and inner granular layer to full retinal atrophy and hypoplasia of the myelinated nerve fibers, respectively. Electron microscopic examination revealed hypoplasia of the myelin sheath of nerve fibers in the right optic nerve. This is an extremely rare case of porencephaly and congenital optic nerve hypoplasia, along with independent retinal thinning.
Identifiants
pubmed: 35221503
doi: 10.1293/tox.2021-0039
pii: 2021-0039
pmc: PMC8828607
doi:
Types de publication
Case Reports
Langues
eng
Pagination
107-111Informations de copyright
©2022 The Japanese Society of Toxicologic Pathology.
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