Association Between Immunoglobulin G
IgG N-glycans
atherosclerosis
biomarker
inflammation
vascular cognitive impairment
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
11
2021
accepted:
07
01
2022
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
1
3
2022
Statut:
epublish
Résumé
Atherosclerosis is considered a crucial component in the pathogenesis of decreased cognitive function, as occurs in vascular cognitive impairment (VCI). Inflammation and the immune response play a significant role in the development of many chronic diseases. Immunoglobulin G (IgG) We recruited a total of 330 patients with atherosclerosis to participate in this case-control study, including 165 VCI patients and 165 sex- and age-matched participants with normal cognitive function. The plasma IgG Through the multivariate logistic regression analysis, 8 glycans and 13 derived traits reflecting decreased sialylation and galactosylation and increased bisecting GlcNAc significantly differed between the case and control groups after adjusting for confounding factors ( The findings indicate that decreased sialylation and galactosylation and increased bisecting GlcNAc reflected by IgG
Sections du résumé
BACKGROUND
BACKGROUND
Atherosclerosis is considered a crucial component in the pathogenesis of decreased cognitive function, as occurs in vascular cognitive impairment (VCI). Inflammation and the immune response play a significant role in the development of many chronic diseases. Immunoglobulin G (IgG)
METHOD
METHODS
We recruited a total of 330 patients with atherosclerosis to participate in this case-control study, including 165 VCI patients and 165 sex- and age-matched participants with normal cognitive function. The plasma IgG
RESULTS
RESULTS
Through the multivariate logistic regression analysis, 8 glycans and 13 derived traits reflecting decreased sialylation and galactosylation and increased bisecting GlcNAc significantly differed between the case and control groups after adjusting for confounding factors (
CONCLUSION
CONCLUSIONS
The findings indicate that decreased sialylation and galactosylation and increased bisecting GlcNAc reflected by IgG
Identifiants
pubmed: 35221999
doi: 10.3389/fnagi.2022.823468
pmc: PMC8868374
doi:
Types de publication
Journal Article
Langues
eng
Pagination
823468Informations de copyright
Copyright © 2022 Wang, Chen, Tang, Zhang, Hou, Sun, Shi, Lu, Li, Ji, Ding and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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