Detection of hepatitis C virus among HIV patients in Port Harcourt, Rivers State.
CD4+ Count
HCV
HIV
Serology
Journal
African health sciences
ISSN: 1729-0503
Titre abrégé: Afr Health Sci
Pays: Uganda
ID NLM: 101149451
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
3
3
2022
Statut:
ppublish
Résumé
Hepatitis C virus (HCV) a major human pathogen infecting millions of individuals worldwide, thereby increasing the risks for chronic liver diseases and has been discovered that HIV/HCV co-infected patients have a greater risk. To determine the prevalence of HCV infection among HIV infected people in Port Harcourt, Rivers State. The patients were from the ages of 18 and above attending the antiretroviral clinic for over 6 months. The mean age of the participants was 36.91±8.38. Data were gotten from the 550 patients using a modified questionnaire and 5mls of blood samples were collected through venepuncture into EDTA bottles and spun at 3000rpm for 10 minutes separating the plasma from the whole blood. The CD4+ count was gotten from the patients' file and the samples kept at -700C till analized. HCV antibody was detected using a commercially available third generation kit manufactured by Melsin Medical Co and statistical analysis was done using a Stata version 16. P value was determined using ANOVA. Total number positive to the HCV antibody was 24(4.4%) of which 8(33.3%) were males, while 16(66.7%) were females. Prevalence (29.2%) was among patients in the 31-35 age range. The CD4+ count ranged from 22-864 cells/µl with a mean value of 303.08±194. From this study HIV/HCV co-infection occurs among HIV infected people in Port Harcourt. The CD4+ count was discovered to be low and was not age, nor gender dependent. HIV infected people should therefore be routinely screened for HCV.
Sections du résumé
BACKGROUND
BACKGROUND
Hepatitis C virus (HCV) a major human pathogen infecting millions of individuals worldwide, thereby increasing the risks for chronic liver diseases and has been discovered that HIV/HCV co-infected patients have a greater risk.
OBJECTIVE
OBJECTIVE
To determine the prevalence of HCV infection among HIV infected people in Port Harcourt, Rivers State.
METHODOLOGY
METHODS
The patients were from the ages of 18 and above attending the antiretroviral clinic for over 6 months. The mean age of the participants was 36.91±8.38. Data were gotten from the 550 patients using a modified questionnaire and 5mls of blood samples were collected through venepuncture into EDTA bottles and spun at 3000rpm for 10 minutes separating the plasma from the whole blood. The CD4+ count was gotten from the patients' file and the samples kept at -700C till analized. HCV antibody was detected using a commercially available third generation kit manufactured by Melsin Medical Co and statistical analysis was done using a Stata version 16. P value was determined using ANOVA.
RESULT
RESULTS
Total number positive to the HCV antibody was 24(4.4%) of which 8(33.3%) were males, while 16(66.7%) were females. Prevalence (29.2%) was among patients in the 31-35 age range. The CD4+ count ranged from 22-864 cells/µl with a mean value of 303.08±194.
CONCLUSION
CONCLUSIONS
From this study HIV/HCV co-infection occurs among HIV infected people in Port Harcourt. The CD4+ count was discovered to be low and was not age, nor gender dependent. HIV infected people should therefore be routinely screened for HCV.
Identifiants
pubmed: 35222562
doi: 10.4314/ahs.v21i3.8
pii: jAFHS.v21.i3.pg1010
pmc: PMC8843266
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1010-1015Informations de copyright
© 2021 Baeka GB et al.
Références
Afr Health Sci. 2012 Sep;12(3):312-7
pubmed: 23382745
Lancet Infect Dis. 2015 Jul;15(7):819-24
pubmed: 25957078
Mem Inst Oswaldo Cruz. 2017 Sep;112(9):632-639
pubmed: 28902289
AIDS. 2007 May 31;21(9):1073-89
pubmed: 17502718
Arch Intern Med. 2006 Aug 14-28;166(15):1632-41
pubmed: 16908797
Arch Immunol Ther Exp (Warsz). 2014 Apr;62(2):145-51
pubmed: 24202543
Pan Afr Med J. 2012;12:100
pubmed: 23133700
Semin Liver Dis. 2011 Nov;31(4):340-6
pubmed: 22189974
AIDS. 2009 Jan 2;23(1):89-93
pubmed: 19050390
J Acquir Immune Defic Syndr. 2007 Jul 1;45 Suppl 2:S47-56; discussion S66-7
pubmed: 17704692
J Gen Virol. 2009 Sep;90(Pt 9):2086-96
pubmed: 19474244
Clin Infect Dis. 2001 Aug 15;33(4):562-9
pubmed: 11462196
AIDS. 2005 Dec 2;19(18):2117-25
pubmed: 16284461
J Infect Dis. 2005 Dec 1;192(11):1880-9
pubmed: 16267758
Liver Int. 2009 Jan;29 Suppl 1:74-81
pubmed: 19207969
Afr Health Sci. 2015 Sep;15(3):728-36
pubmed: 26957959
Gastroenterology. 2009 Sep;137(3):795-814
pubmed: 19549523
J Clin Microbiol. 2015 Mar;53(3):967-72
pubmed: 25520447
AIDS. 2010 Jul 17;24(11):1689-95
pubmed: 20467290