Salivary Fluoride Bioavailability after Brushing with Brazilian Red Propolis Dentifrice: A Clinical Study.
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
09
2021
revised:
14
12
2021
accepted:
10
01
2022
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
1
3
2022
Statut:
epublish
Résumé
Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products. This study aimed to evaluate the availability of fluoride in saliva samples after using a dentifrice incorporated with Brazilian red propolis (BRP, INPI Patent no. BR1020170110974) and to compare it to a conventional fluoridated dentifrice in healthy participants. This study was conducted implementing a double-blind, randomized, controlled, and crossover design. Saliva samples of participants were collected at the following time points: 0 at baseline and 5, 15, 30, 45, and 60 minutes after brushing with each dentifrice. Salivary fluoride concentrations showed no statistically significant difference when comparing the two treatments ( The results showed that there was no difference between the analyzed fluoride concentrations 1 hour after brushing with the different dentifrices. The results of this study suggest that the propolis incorporated in the dentifrice did not interfere with the kinetics and bioavailability of the fluoride ion in saliva samples, enabling its integration with the pharmaceutical formula and thereby promoting its anti-inflammatory and antimicrobial benefits without compromising the anticaries activity of the formulation.
Identifiants
pubmed: 35222673
doi: 10.1155/2022/6148137
pmc: PMC8881157
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6148137Informations de copyright
Copyright © 2022 Francisco Josimar Girão Júnior et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
Références
Saudi Pharm J. 2019 Mar;27(3):363-367
pubmed: 30976179
BMC Oral Health. 2019 Jun 18;19(1):119
pubmed: 31215467
Caries Res. 2000 Sep-Oct;34(5):404-11
pubmed: 11014907
Caries Res. 2019;53(6):675-681
pubmed: 31307037
BMC Oral Health. 2012 Jan 09;12:3
pubmed: 22230722
Evid Based Complement Alternat Med. 2014;2014:371730
pubmed: 24772179
Evid Based Complement Alternat Med. 2020 Jan 21;2020:8532701
pubmed: 32063987
J Toxicol Environ Health B Crit Rev. 2017;20(8):447-469
pubmed: 29182464
Recent Pat Biotechnol. 2020;14(1):41-48
pubmed: 31448718
PLoS One. 2017 Mar 30;12(3):e0172585
pubmed: 28358806
Arch Oral Biol. 2019 Nov;107:104512
pubmed: 31382160
Evid Based Complement Alternat Med. 2017;2017:5370545
pubmed: 28261310
Caries Res. 2020;54(2):185-193
pubmed: 32213768
Caries Res. 2001 Mar-Apr;35(2):116-24
pubmed: 11275671
J Clin Diagn Res. 2016 May;10(5):ZC88-91
pubmed: 27437368
Caries Res. 2019;53(2):119-136
pubmed: 30041245
Clin Oral Investig. 2018 Apr;22(3):1123-1129
pubmed: 28865065
Indian J Dent. 2016 Apr-Jun;7(2):76-80
pubmed: 27433050
Saudi J Biol Sci. 2020 Nov;27(11):3079-3086
pubmed: 33100868
Eur J Dent. 2019 Jul;13(3):459-465
pubmed: 31795009
J Dent Res. 2019 Jul;98(8):837-846
pubmed: 31282846
Braz Oral Res. 2014;28 Spec No:1-7
pubmed: 24554097
Nat Rev Dis Primers. 2017 May 25;3:17030
pubmed: 28540937
Biofouling. 2013;29(10):1233-42
pubmed: 24099330