Early Recognition and Treatment of Relapsing Polychondritis.
anti-type 2 collagen antibody
autoimmune disease
c-reactive protein
ear swelling
relapsing polychondritis
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
accepted:
20
01
2022
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
1
3
2022
Statut:
epublish
Résumé
We describe the case of a 60-year-old Japanese man with relapsing polychondritis (RP). The patient was referred to Hamanomachi Hospital due to mild elevation of C-reactive protein and mild anemia on medical checkup without any symptoms. Body CT imaging showed thickened tracheal and bronchial walls with no active lesions in the lung. Precise physical examination revealed swelling in both ears. Bronchoscopy revealed redness and swelling of the tracheal and bronchial mucosa in the membranous lesion. Histologic examination of the bronchial biopsy showed inflammatory cell infiltration in the sub-mucosa with no vasculitis. Serum anti-type 2 collagen antibodies were found to be positive (33.9 EU/mL). Corticosteroid treatment improved his tracheochondritis. It is challenging to diagnose RP in the early stage due to its rarity and nonspecific symptoms. Airway involvement in RP is irreversible and the major cause of morbidity and mortality; hence, early recognition of airway involvement and treatment is warranted.
Identifiants
pubmed: 35223247
doi: 10.7759/cureus.21463
pmc: PMC8862614
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e21463Informations de copyright
Copyright © 2022, Yanagihara et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Medicine (Baltimore). 1976 May;55(3):193-215
pubmed: 775252
SAGE Open Med Case Rep. 2019 Mar 08;7:2050313X19832164
pubmed: 30886718
Clin Epidemiol. 2016 Jun 23;8:211-30
pubmed: 27418855
Laryngoscope. 1979 Jun;89(6 Pt 1):929-46
pubmed: 449538
Rheumatology (Oxford). 2018 Sep 1;57(9):1525-1532
pubmed: 29126262
Ann Intern Med. 1986 Jan;104(1):74-8
pubmed: 3484422
ERJ Open Res. 2021 Feb 15;7(1):
pubmed: 33614776
N Engl J Med. 1978 Nov 30;299(22):1203-7
pubmed: 714080
Jpn J Med. 1990 Jan-Feb;29(1):91-4
pubmed: 2214354
Curr Opin Rheumatol. 2004 Jan;16(1):56-61
pubmed: 14673390
AJR Am J Roentgenol. 2011 Mar;196(3):W240-6
pubmed: 21343471
Ann Rheum Dis. 2018 Aug;77(8):1172-1178
pubmed: 29535124
Ann Intern Med. 1998 Jul 15;129(2):114-22
pubmed: 9669970
BMJ Case Rep. 2014 Sep 11;2014:
pubmed: 25213785
Rheumatology (Oxford). 2015 Dec;54(12):2181-7
pubmed: 26187053
Ann Rheum Dis. 1981 Oct;40(5):473-9
pubmed: 7030234