Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy.
NIR upconversion theranostic nanoparticles
PEI
TAT
gene therapy.
lanthanide-based β-TCP
Journal
Nanotheranostics
ISSN: 2206-7418
Titre abrégé: Nanotheranostics
Pays: Australia
ID NLM: 101698994
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
11
2021
accepted:
13
01
2022
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
17
3
2022
Statut:
epublish
Résumé
Lanthanide-based beta-tricalcium phosphate (β-TCP) upconversion nanoparticles are exploited as a non-viral vector for imaging guided-gene therapy by virtue of their unique optical properties and multi-modality imaging ability, high transfection efficiency, high biocompatibility, dispersibility, simplicity of synthesis and surface modification. Ytterbium and thulium-doped β-TCP nanoparticles (βTCPYbTm) are synthesized via co-precipitation method, coated with polyethylenimine (PEI) and functionalized with a nuclear-targeting peptide (TAT). Further,
Identifiants
pubmed: 35223382
doi: 10.7150/ntno.68789
pii: ntnov06p0306
pmc: PMC8864251
doi:
Substances chimiques
Calcium Phosphates
0
Lanthanoid Series Elements
0
beta-tricalcium phosphate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
306-321Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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