Factors Affecting the Long-Term Survival of Kidney Transplantation in Northeastern of Iran between 2000 and 2015.

Chronic Graft survival Kidney failure Kidney transplantation Proportional hazards models Survival rate

Journal

Iranian journal of public health
ISSN: 2251-6093
Titre abrégé: Iran J Public Health
Pays: Iran
ID NLM: 7505531

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 09 01 2020
accepted: 15 03 2020
entrez: 28 2 2022
pubmed: 1 3 2022
medline: 1 3 2022
Statut: ppublish

Résumé

Graft and patient survival are of great importance after transplantation. This study aimed to determine the long-term survival rate of kidney transplantation and its effective factors among transplanted patients in Mashhad transplantation centers in northeastern Iran. Overall, 618 kidney transplant recipients were examined in different transplantation centers during the years from 2000 to 2015 in a historical cohort study. The Kaplan-Meier method and the Log-rank test were used to calculate the survival rate of the kidney transplant, and to check the difference between survival curves respectively. Modeling of effective factors in survival rate was performed using Cox regression model. Overall, 1, 3, 5, 7, 10, and 15-year survival rate of kidney transplantation were 99%, 98%, 97%, 93%, 88 and 70% respectively. The adjusted hazard ratio indicated that variables such as recipient age >40 yr [HR=0.22, 95% CI=(0.071,0.691)], serum creatinine after transplantation >1.6 Mg/dl [HR=3.03, 95% CI=(1.284,7.125)], history of hypertension [HR=6.70, 95% CI=(2.746,16.348)], and BMI [HR (normal weight versus underweight)=0.26, 95% CI=(0.088,0.761), HR (over weight versus underweight)=0.13,95% CI=(0.038,0.442)] were significant factors on kidney transplant survival rate. The short-term transplant survival rate was good in transplant patients. What's more, through a consideration of variables such as age, creatinine serum after transplantation, history hypertension and body mass index, as well as proper planning to control their effect, it is possible to improve the long-term graft survival rate.

Sections du résumé

BACKGROUND BACKGROUND
Graft and patient survival are of great importance after transplantation. This study aimed to determine the long-term survival rate of kidney transplantation and its effective factors among transplanted patients in Mashhad transplantation centers in northeastern Iran.
METHODS METHODS
Overall, 618 kidney transplant recipients were examined in different transplantation centers during the years from 2000 to 2015 in a historical cohort study. The Kaplan-Meier method and the Log-rank test were used to calculate the survival rate of the kidney transplant, and to check the difference between survival curves respectively. Modeling of effective factors in survival rate was performed using Cox regression model.
RESULTS RESULTS
Overall, 1, 3, 5, 7, 10, and 15-year survival rate of kidney transplantation were 99%, 98%, 97%, 93%, 88 and 70% respectively. The adjusted hazard ratio indicated that variables such as recipient age >40 yr [HR=0.22, 95% CI=(0.071,0.691)], serum creatinine after transplantation >1.6 Mg/dl [HR=3.03, 95% CI=(1.284,7.125)], history of hypertension [HR=6.70, 95% CI=(2.746,16.348)], and BMI [HR (normal weight versus underweight)=0.26, 95% CI=(0.088,0.761), HR (over weight versus underweight)=0.13,95% CI=(0.038,0.442)] were significant factors on kidney transplant survival rate.
CONCLUSION CONCLUSIONS
The short-term transplant survival rate was good in transplant patients. What's more, through a consideration of variables such as age, creatinine serum after transplantation, history hypertension and body mass index, as well as proper planning to control their effect, it is possible to improve the long-term graft survival rate.

Identifiants

DOI: 10.18502/ijph.v50i10.7508 PMID: 35223575 PMC: PMC8819232
pubmed: 35223575
doi: 10.18502/ijph.v50i10.7508
pii: IJPH-50-2076
pmc: PMC8819232
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2076-2084

Informations de copyright

Copyright © 2021 Alimi et al. Published by Tehran University of Medical Sciences.

Déclaration de conflit d'intérêts

Conflict of interest The authors state that there are no conflicts of interest.

Références

Saudi J Kidney Dis Transpl. 2009 May;20(3):501-4
pubmed: 19414964
PLoS One. 2016 Apr 13;11(4):e0153410
pubmed: 27074003
Medicina (Kaunas). 2017;53(4):224-232
pubmed: 28802764
Am J Cardiol. 2007 Sep 15;100(6):1020-5
pubmed: 17826390
Transplant Proc. 2007 May;39(4):907-10
pubmed: 17524847
Nephrol Dial Transplant. 2012 Dec;27 Suppl 4:iv39-46
pubmed: 23258810
Transplant Proc. 2010 Oct;42(8):2856-8
pubmed: 20970550
N Engl J Med. 2002 Jun 27;346(26):2089-92; author reply 2089-92
pubmed: 12088021
Iran J Kidney Dis. 2014 May;8(3):225-30
pubmed: 24878946
Saudi J Kidney Dis Transpl. 2014 May;25(3):697-702
pubmed: 24821181
Nephrol Dial Transplant. 2004 Nov;19(11):2864-9
pubmed: 15496562
Am J Kidney Dis. 2012 Jan;59(1 Suppl 1):A7, e1-420
pubmed: 22177944
Iran J Kidney Dis. 2008 Oct;2(4):183-92
pubmed: 19377235
J Am Soc Nephrol. 2007 Jun;18(6):1973-85
pubmed: 17460145
QJM. 2008 Dec;101(12):967-78
pubmed: 18927195
Iran J Public Health. 2015 May;44(5):683-9
pubmed: 26284210
Chin Med J (Engl). 2011 Apr;124(8):1181-4
pubmed: 21542992
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Transplantation. 2010 Mar 27;89(6):694-701
pubmed: 20308863
JRSM Short Rep. 2012 Jun;3(6):38
pubmed: 22768372
Iran J Kidney Dis. 2009 Oct;3(4):192-6
pubmed: 19841521
Transplant Proc. 2003 Feb;35(1):147-8
pubmed: 12591342
Nephrol Dial Transplant. 2012 Apr;27(4):1663-71
pubmed: 21926404
J Res Med Sci. 2015 Nov;20(11):1046-52
pubmed: 26941807
Iran J Kidney Dis. 2014 Mar;8(2):109-15
pubmed: 24685733
Ann Surg. 2001 Aug;234(2):149-64
pubmed: 11505060
Indian J Nephrol. 2010 Oct;20(4):179-84
pubmed: 21206678
Health Technol Assess. 2005 May;9(21):1-179, iii-iv
pubmed: 15899149
Transplant Proc. 2004 Sep;36(7):2040-2
pubmed: 15518738
Am J Transplant. 2010 Oct;10(10):2279-86
pubmed: 20883559
Saudi J Kidney Dis Transpl. 2014 Nov;25(6):1334-40
pubmed: 25394462
J Am Geriatr Soc. 2014 Oct;62(10):1877-82
pubmed: 25284598
J Natl Med Assoc. 2009 Feb;101(2):111-5
pubmed: 19378626
BMC Med. 2015 May 12;13:111
pubmed: 25963131
Ann Transplant. 2013 Apr 05;18:153-60
pubmed: 23792515
Transplantation. 2007 Oct 27;84(8):981-7
pubmed: 17989603
Iran J Public Health. 2014 Mar;43(3):316-22
pubmed: 25988091

Auteurs

Rasoul Alimi (R)

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Maryam Hami (M)

Kidney Transplantation Complications Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Monavar Afzalaghaee (M)

Management & Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Fatemeh Nazemian (F)

Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Mahmood Mahmoodi (M)

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Mehdi Yaseri (M)

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Hojjat Zeraati (H)

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Classifications MeSH