The protein corona modulates the inflammation inhibition by cationic nanoparticles
Cationic nanoparticles
Cell-free DNA
Inflammation inhibition
Protein corona
Rheumatoid arthritis
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
15
08
2021
revised:
06
10
2021
accepted:
28
10
2021
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
1
3
2022
Statut:
epublish
Résumé
A central paradigm in nanomedicine is that when synthetic nanoparticles (NPs) enter the body, they are immediately cloaked by a corona of macromolecules (mostly proteins) that mediates the role of the physico-chemical properties in the NP biological functions (the "coronation paradigm"). In this work, we focused on the assessment of the "coronation paradigm" for cationic NPs (cNPs) used as rheumatoid arthritis (RA) drugs due to their ability to scavenge cell-free DNA (cfDNA). We fabricated series of cNPs uniformly coated with single or di-hydroxyl groups and different types of amino groups and showed that hydroxylated nanoparticles displayed a prolonged retention in inflamed joints and greater anti-inflammatory effect in collagen-induced arthritis (CIA) rats than the non-hydroxylated analogues. Especially, the cNPs with secondary amines and a di-hydroxyl shell showed the best performance among the tested cNPs. Proteomic analysis showed that the cNPs with a di-hydroxyl shell adsorbed less opsonin proteins than the cNPs carrying mono hydroxyl groups and non-hydroxylated ones, which may provide a mechanistic explanation for the different biodistribution profiles of cNPs. Thus, this study suggests that the protein corona mediates the effects of the surface chemistry on the fate and functions of cNPs as anti-RA drugs.
Identifiants
pubmed: 35224306
doi: 10.1016/j.bioactmat.2021.10.044
pii: S2452-199X(21)00508-9
pmc: PMC8843952
doi:
Types de publication
Journal Article
Langues
eng
Pagination
249-259Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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