A Comprehensive Review of Biological Roles and Interactions of Cullin-5 Protein.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
06
12
2021
accepted:
26
01
2022
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
1
3
2022
Statut:
epublish
Résumé
Ubiquitination is a modification of proteins that has a powerful impact on protein function along with other cellular functions. This reaction is regulated through major enzymes, including E3 ligase as a chief enzyme. The Cullin-5 ubiquitin ligase (Cul5) possesses a variety of substrates that maintain the process of ubiquitination as well as proteasomal degradation. It regulates cell development, proliferation, and other physiological tasks in the human body. Moreover, it has been discovered that the expression of Cul5 plays a significant role in specific cancer cells while affecting the progression of tumor cells. This review is based on current knowledge about Cul5 and its expression, signaling pathways, regulation, virus-related responses, and inhibitors for therapeutic strategies.
Identifiants
pubmed: 35224323
doi: 10.1021/acsomega.1c06890
pmc: PMC8867543
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
5615-5624Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Mol Cell Biol. 2005 Jun;25(11):4716-26
pubmed: 15899873
Am J Transl Res. 2020 Feb 15;12(2):618-632
pubmed: 32194910
Semin Cancer Biol. 2020 Dec;67(Pt 2):61-79
pubmed: 32334051
Cell Div. 2016 Mar 09;11:1
pubmed: 27030794
Oncogenesis. 2019 Jan 9;8(1):4
pubmed: 30631037
Cancer Biol Med. 2021 Mar 18;:
pubmed: 33733647
Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1587-97
pubmed: 23897481
Int J Mol Sci. 2021 Oct 22;22(21):
pubmed: 34768863
Nat Commun. 2020 Sep 8;11(1):4482
pubmed: 32901011
Bioengineered. 2021 Dec;12(1):5348-5360
pubmed: 34415831
Int J Pharm. 2019 Jun 10;564:281-292
pubmed: 30999048
Aging (Albany NY). 2020 Sep 14;12(17):17380-17392
pubmed: 32931454
Cell Signal. 2018 Apr;44:92-102
pubmed: 29331584
J Biol Chem. 2021 Jul;297(1):100862
pubmed: 34116057
Curr Biol. 2009 Jan 27;19(2):157-62
pubmed: 19147357
Cell Div. 2016 Jun 10;11:8
pubmed: 27293474
Int J Mol Sci. 2021 Jan 09;22(2):
pubmed: 33435370
J Mol Biol. 2009 Mar 20;387(1):162-74
pubmed: 19385048
Nat Immunol. 2006 Feb;7(2):148-55
pubmed: 16415872
Cell Death Dis. 2021 Mar 12;12(3):265
pubmed: 33712558
Nature. 2020 Feb;578(7795):461-466
pubmed: 32051583
Cell Biosci. 2021 Mar 17;11(1):55
pubmed: 33731189
Arch Biochem Biophys. 2019 Feb 15;662:93-100
pubmed: 30521783
Cell. 2012 Aug 31;150(5):987-1001
pubmed: 22939624