The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors.
affinity
antagonist
antidepressant
antipsychotic
hypertension
selectivity
α-adrenoceptor
Journal
Pharmacology research & perspectives
ISSN: 2052-1707
Titre abrégé: Pharmacol Res Perspect
Pays: United States
ID NLM: 101626369
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
19
01
2022
received:
26
11
2021
accepted:
20
01
2022
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
21
4
2022
Statut:
ppublish
Résumé
α2-Adrenoceptors, subdivided into α2A, α2B, and α2C subtypes and expressed in heart, blood vessels, kidney, platelets and brain, are important for blood pressure, sedation, analgesia, and platelet aggregation. Brain α2C-adrenoceptor blockade has also been suggested to be beneficial for antipsychotic action. However, comparing α2-adrenoceptor subtype affinity is difficult due to significant species and methodology differences in published studies. Here,
Identifiants
pubmed: 35224877
doi: 10.1002/prp2.936
pmc: PMC8882856
doi:
Substances chimiques
Antidepressive Agents
0
Antipsychotic Agents
0
Receptors, Adrenergic, alpha-1
0
Yohimbine
2Y49VWD90Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e00936Informations de copyright
© 2022 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.
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