Therapeutic effects of dexamethasone-loaded hyaluronan nanogels in the experimental cholestasis.

Animals Bicarbonates / metabolism Budesonide Cholestasis / drug therapy Dexamethasone Hyaluronic Acid Mice Nanogels Rats
Cholestasis Dexamethasone Hyaluronic acid Nanogels Primary biliary cholangitis

Journal

Drug delivery and translational research
ISSN: 2190-3948
Titre abrégé: Drug Deliv Transl Res
Pays: United States
ID NLM: 101540061

Informations de publication

Date de publication:
08 2022
Historique:
accepted: 04 02 2022
pubmed: 1 3 2022
medline: 2 7 2022
entrez: 28 2 2022
Statut: ppublish

Résumé

A major function of the intrahepatic biliary epithelium is bicarbonate excretion in bile. Recent reports indicate that budesonide, a corticosteroid with high receptor affinity and hepatic first pass clearance, increases the efficacy of ursodeoxycholic acid, a choleretic agent, in primary biliary cholangitis patients. We have previously reported that bile ducts isolated from rats treated with dexamethasone or budesonide showed an enhanced activity of the Na

Identifiants

DOI: 10.1007/s13346-022-01132-7 PMID: 35226290 PMC: PMC9242918
pubmed: 35226290
doi: 10.1007/s13346-022-01132-7
pii: 10.1007/s13346-022-01132-7
pmc: PMC9242918
doi:

Substances chimiques

Bicarbonates 0
Nanogels 0
Budesonide 51333-22-3
Dexamethasone 7S5I7G3JQL
Hyaluronic Acid 9004-61-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1959-1973

Informations de copyright

© 2022. The Author(s).

Références

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Auteurs

Sabina Di Matteo (S)

Department of Immunology, Bambino Gesù Childrens Hospital, IRCCS, Rome, Italy.
ORCID: 0000-0002-2586-7159

Chiara Di Meo (C)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy. chiara.dimeo@uniroma1.it.
ORCID: 0000-0002-3531-6107

Guido Carpino (G)

Department of Movement, Division of Health Sciences, Human and Health Sciences, University of Rome "Foro Italico, Rome, Italy.

Nicole Zoratto (N)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.

Vincenzo Cardinale (V)

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy. vincenzo.cardinale@uniroma1.it.

Lorenzo Nevi (L)

Department of Biosciences, University of Milan, Milan, Italy.

Diletta Overi (D)

Department of Anatomical, Forensic, Medicine and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

Daniele Costantini (D)

Department of Precision and Translational Medicine, Sapienza University of Rome, Rome, Italy.

Claudio Pinto (C)

Department of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.

Elita Montanari (E)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.

Marco Marzioni (M)

Department of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.

Luca Maroni (L)

Department of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.

Antonio Benedetti (A)

Department of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ancona, Italy.

Marco Viola (M)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.

Tommasina Coviello (T)

Department of Movement, Division of Health Sciences, Human and Health Sciences, University of Rome "Foro Italico, Rome, Italy.

Pietro Matricardi (P)

Department of Movement, Division of Health Sciences, Human and Health Sciences, University of Rome "Foro Italico, Rome, Italy.

Eugenio Gaudio (E)

Department of Anatomical, Forensic, Medicine and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

Domenico Alvaro (D)

Department of Precision and Translational Medicine, Sapienza University of Rome, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Carbonates › Hydrogénocarbonates › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnènes › Prégnènediones › Budésonide › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladie des voies biliaires › Maladies des canaux biliaires › Cholestase › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Stéroïdes fluorés › Dexaméthasone › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Acide hyaluronique › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanogels › Therapeutic effects of dexamethasone-loaded...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Therapeutic effects of dexamethasone-loaded...