Genetic Lipid Disorders Associated with Atherosclerotic Cardiovascular Disease: Molecular Basis to Clinical Diagnosis and Epidemiologic Burden.
Atherosclerosis
Cardiovascular disease
Genetics
Hypercholesterolemia
Lipids
Journal
The Medical clinics of North America
ISSN: 1557-9859
Titre abrégé: Med Clin North Am
Pays: United States
ID NLM: 2985236R
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
entrez:
1
3
2022
pubmed:
2
3
2022
medline:
3
3
2022
Statut:
ppublish
Résumé
Genetic lipid disorders, ranging from common dyslipidemias such as familial hypercholesterolemia, lipoprotein (a), and familial combined hyperlipidemia to rare disorders including familial chylomicronemia syndrome and inherited hypoalphalipoproteinemias (ie, Tangier and fish eye diseases), affect millions of individuals in the United States and tens of millions around the world and are often undiagnosed in the general population. Clinicians should take into consideration the potential of inherited lipid disorders or syndromes when severe derangements in lipid parameters are observed. Patients' combined genotype and phenotype should be evaluated in conjunction with a host of environmental factors impacting their risk of atherosclerotic cardiovascular disease.
Identifiants
pubmed: 35227434
pii: S0025-7125(21)00168-1
doi: 10.1016/j.mcna.2021.11.009
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-348Informations de copyright
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