Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
28 Feb 2022
28 Feb 2022
Historique:
received:
15
10
2021
accepted:
19
01
2022
entrez:
1
3
2022
pubmed:
2
3
2022
medline:
2
3
2022
Statut:
epublish
Résumé
Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neutralization activities one month following the first and second COVID-19 vaccine doses, and again 3 months following the second dose, in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525-935) cells/mm
Identifiants
pubmed: 35228535
doi: 10.1038/s41541-022-00452-6
pii: 10.1038/s41541-022-00452-6
pmc: PMC8885829
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01AI134229
Organisme : Genome British Columbia
ID : VAC-009
Organisme : Michael Smith Foundation for Health Research (MSFHR)
ID : Scholar Award
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Michael Smith Foundation for Health Research (MSFHR)
ID : VAC-009
Organisme : BCCDC Foundation for Public Health (BCCDC Foundation for Population and Public Health)
ID : VAC-009
Organisme : Wellcome Trust (Wellcome)
ID : 107752/Z/15/Z
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2022. The Author(s).
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