Early high amino-acid intake is associated with hypophosphatemia in preterm infants.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
03
08
2021
accepted:
17
02
2022
revised:
25
01
2022
pubmed:
2
3
2022
medline:
6
8
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
To estimate the incidence of hypophosphatemia in preterm infants according to parenteral nutrition received and to evaluate associated risk factors. A prospective multicenter cohort study included 111 patients ≤ 1250 g (7 NICUs of the NEOCOSUR Network). Two groups were compared according to the amino-acid supply in the first 48 h: aggressive parenteral group ≥ 3 g/kg/day and standard parenteral group: <2.9 g/kg/day. Hypophosphatemia was defined as serum phosphate < 4 mg/dl. A logistic regression analysis was performed to evaluate associated risk factors. Fifty-eight infants received aggressive parenteral nutrition. The incidence of hypophosphatemia was significantly higher in the aggressive parenteral group (77.5% vs 53.8%, p = 0.009). Hypophosphatemia was independently associated with aggressive parenteral nutrition (aOR 4.16 95% CI 1.54-12.24) and negatively associated with phosphorous intake (aOR 0.92 95% CI 0.87-0.97). Both high amino-acid intake and low phosphorus supply during the first days after birth were independently associated with hypophosphatemia.
Identifiants
pubmed: 35228683
doi: 10.1038/s41372-022-01361-1
pii: 10.1038/s41372-022-01361-1
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1063-1069Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
Références
Van Den Akker CH, Vlaardingerbroek H, Van Goudoever JB. Nutritional support for extremely low-birth weight infants: abandoning catabolism in the neonatal intensive care unit. Curr Opin Clin Nutr Metab Care. 2010;13:327–35.
doi: 10.1097/MCO.0b013e328337d925
Thureen PJ. Early aggressive nutrition in the neonate. Pediatr Rev. 2007;20:45e–55.
doi: 10.1542/pir.20.9.e45
Senterre T, Rigo J. Reduction in postnatal cumulative nutritional deficit and improvement of growth in extremely preterm infants. Acta Paediatr. 2012;101:64–70.
doi: 10.1111/j.1651-2227.2011.02443.x
Dinerstein A, Nieto RM, Solana CL, Perez GP, Otheguy LE, Larguia AM. Early and aggressive nutritional strategy (parenteral and enteral) decreases postnatal growth failure in very low birth weight infants. J Perinatol. 2006;26:436–42.
doi: 10.1038/sj.jp.7211539
Ehrenkranz RA. Early, aggressive nutritional management for very low birth weight infants: what is the evidence? Semin Perinatol. 2007;31:48–55.
doi: 10.1053/j.semperi.2007.02.001
Hay WW Jr. Aggressive nutrition of the preterm infant. Curr Pediatr Rep. 2013;1:1–17.
doi: 10.1007/s40124-013-0026-4
Senterre T, Abu Zahirah I, Pieltain C, de Halleux V, Rigo J. Electrolyte and mineral homeostasis after optimizing early macronutrient intakes in VLBW infants on parenteral nutrition. J Pediatr Gastroenterol Nutr. 2015;61:491–8.
doi: 10.1097/MPG.0000000000000854
Ehrenkranz RA. Early nutritional support and outcomes in ELBW infants. Early Hum Dev. 2010;86:21–5.
doi: 10.1016/j.earlhumdev.2010.01.014
Bonsante F, Iacobelli S, Latorre G, Rigo J, de Felice C, Robillard PY, et al. Initial amino acid intake influences phosphorus and calcium homeostasis in preterm infants - it is time to change the composition of the early parenteral nutrition. PLoS ONE. 2013;8:1–9.
doi: 10.1371/journal.pone.0072880
Moltu SJ, Strømmen K, Blakstad EW, Almaas AN, Westerberg AC, Brække K, et al. Enhanced feeding in very-low-birth-weight infants may cause electrolyte disturbances and septicemia–a randomized, controlled trial. Clin Nutr. 2013;32:207–12.
doi: 10.1016/j.clnu.2012.09.004
Craddock PR, Yawata Y, VanSanten L, Gilberstadt S, Silvis S, Jacob HS. Acquired phagocyte dysfunction. A complication of the hypophosphatemia of parenteral hyperalimentation. N Engl J Med. 1974;290:1403–7.
doi: 10.1056/NEJM197406202902504
Brener Dik PH, Galletti MF, Fernández Jonusas SA, Alonso G, Mariani GL, Fustiñana CA. Early hypophosphatemia in preterm infants receiving aggressive parenteral nutrition. J Perinatol. 2015;35:712–5.
doi: 10.1038/jp.2015.54
Ross JR, Finch C, Ebeling M, Taylor SN. Refeeding syndrome in very-low-birth-weight intrauterine growth-restricted neonates. J Perinatol. 2013;33:717–20.
doi: 10.1038/jp.2013.28
Bustos Lozano G, Hidalgo Romero Á, Melgar Bonis A, Ureta Velasco N, Orbea Gallardo C, Pallás, et al. Early hypophosphataemia in at risk newborns. Frequency Magnit Pediatr. 2018;88:216–22.
Yang SM, Noh OK, Lee JH, Park MS. Late and insufficient phosphorus supplementation is associated with early severe hypophosphatemia in extremely low birth weight infants with early amino acid administration. Perinatology. 2018;29:13.
doi: 10.14734/PN.2018.29.1.13
Trivedi A, Sinn John KH. Early versus late administration of amino acids in preterm infants receiving parenteral nutrition. Cochrane Database Syst Rev. 2013. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008771.pub2/abstract .
Bustos Lozano G, Soriano-Ramos M, Pinilla Martín MT, Chumillas Calzada S, García Soria CE, Pallás-Alonso CR. Early hypophosphatemia in high-risk preterm infants: efficacy and safety of sodium glycerophosphate from first day on parenteral nutrition. J Parenter Enter Nutr. 2019;43:419–25.
doi: 10.1002/jpen.1426
Pająk A, Królak-Olejnik B, Szafrańska A. Early hypophosphatemia in very low birth weight preterm infants. Adv Clin Exp Med. 2018;27:841–7.
doi: 10.17219/acem/70081
Senterre J, Salle B. Renal aspects of calcium and phosphorus metabolism in preterm infants. Biol Neonate. 1988;53:220–9.
doi: 10.1159/000242794
Torrazza RM, Neu J. Evidence-based guidelines for optimization of nutrition for the very low birthweight infant. Neoreviews. 2013;14:e340–9.
doi: 10.1542/neo.14-7-e340
Ichikawa G, Watabe Y, Suzumura H, Sairenchi T, Muto T, Arisaka O. Hypophosphatemia in small for gestational age extremely low birth weight infants receiving parenteral nutrition in the first week after birth. J Pediatr Endocrinol Metab. 2012;25:317–21.
doi: 10.1515/jpem-2011-0485
Vileisis RA. Effect of phosphorous intake in total parenteral nutrition infusates in premature neonates. J Pediatr. 1987;110:586–90.
doi: 10.1016/S0022-3476(87)80558-9
Moe K, Beck-Nielsen SS, Lando A, Greisen G, Zachariassen G. Administering different levels of parenteral phosphate and amino acids did not influence growth in extremely preterm infants. Acta Paediatr. 2015;104:894–9.
doi: 10.1111/apa.13063
Mihatsch W, Fewtrell M, Goulet O, Molgaard C, Picaud JC, Senterre T, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: calcium, phosphorus and magnesium. Clin Nutr. 2018;37:2360–5.
doi: 10.1016/j.clnu.2018.06.950
Johnson PJ. Review of micronutrients in parenteral nutrition for the NICU population. Neonatal Netw. 2014;33:155–61.
doi: 10.1891/0730-0832.33.3.155
Mulla S, Stirling S, Cowey S, Close R, Pullan S, Howe R, et al. Severe hypercalcaemia and hypophosphataemia with an optimised preterm parenteral nutrition formulation in two epochs of differing phosphate supplementation. Arch Dis Child Fetal Neonatal Ed. 2017;102:F451–5.
doi: 10.1136/archdischild-2016-311107
Boubred F, Herlenius E, Bartocci M, Jonsson B, Vanpée M. Extremely preterm infants who are small for gestational age have a high risk of early hypophosphatemia and hypokalemia. Acta Paediatr. 2015;104:1077–83.
doi: 10.1111/apa.13093
Mena Nannig P, Cubillos Celis MP, Toro Jara C, Zuñiga Vergara C. Prematuro Extremo - Perfil Bioquímico en Sangre Cordón y Crecimiento Fetal. Rev Chil Pediatr. 2016;87:250–4.
doi: 10.1016/j.rchipe.2015.11.002