Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury.

ADMSC, adipose-derived mesenchymal stem cells BMSCs, bone marrow-derived mesenchymal stem cells Cardiac injury Cell repair and regeneration EGF, epidermal growth factor FDPs, fibrin degradation products FGFs, fibroblast growth factors HGF, hepatocyte growth factor IGF-I, insulin-like growth factor-I IRI, ischemic reperfusion injury ISO, Isoproterenol LP-PRP, leukocyte-poor PRP LR-PRP, leukocyte-rich PRP MH, Manuka honey MI, myocardial infarction MRI, magnetic resonance imaging P-PRF, pure platelet-rich fibrin PDGF, platelet-derived growth factor PRP, platelet-rich plasma Platelet-rich plasma ROS, reactive oxygen species TGF-b, transforming growth factor beta VEGF, vascular endothelial growth factor nsPEF, nanosecond pulsed electric fields

Journal

Regenerative therapy
ISSN: 2352-3204
Titre abrégé: Regen Ther
Pays: Netherlands
ID NLM: 101709085

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 21 12 2021
revised: 18 01 2022
accepted: 27 01 2022
entrez: 1 3 2022
pubmed: 2 3 2022
medline: 2 3 2022
Statut: epublish

Résumé

Platelet-rich plasma (PRP) is a widely accepted treatment approach and has heightened the quality of care among physicians. PRP has been used over the last decade to boost clinical results of plastic therapies, periodontal surgery and intra-bony defects. According to certain research, elevated levels of PRP growth factors that could promote tissue repair and have the potential for PRP to be beneficial in regenerating processes that Maxillofacial and Oral Surgeons, Veterinary Officers, Athletic medicine specialists and Dermatologists have long admired. PRP is an autologous whole blood fraction that has a heavy amount of a variety of growth factors such as epidermal growth factor (EGF), Vascular Endothelial Growth Factor (VEGF), hepatocyte growth factor (HGF), fibroblast growth factors (FGFs), transforming growth factor beta-1 (TGF-b), insulin-like growth factor-I (IGF-I) and platelet-derived growth factor (PDGF) which can facilitate repair and regeneration. Moreover, a clinical trial of PRP in severe angina patients has shown its excellent safety profile. However, PRP is a very complex biological substance with an array of active biomolecules, its functions are yet to be fully clarified. In-addition, there was insufficient work assessing possible cardiovascular tissue benefits from PRP. Thus, it still remains necessary to identify the most clinically important cardiovascular applications and further research in clinical scenario need to be validated.

Identifiants

pubmed: 35229012
doi: 10.1016/j.reth.2022.01.006
pii: S2352-3204(22)00006-2
pmc: PMC8856949
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

144-153

Informations de copyright

© 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

Déclaration de conflit d'intérêts

The authors have no conflict of interests.

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Auteurs

Syed Sarim Imam (SS)

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Fahad A Al-Abbasi (FA)

Department of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah 21589 Saudi Arabia.

Salman Hosawi (S)

Department of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah 21589 Saudi Arabia.

Muhammad Afzal (M)

Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf-72341, Saudi Arabia.

Muhammad Shahid Nadeem (MS)

Department of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah 21589 Saudi Arabia.

Mohammed M Ghoneim (MM)

Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia.

Sultan Alshehri (S)

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Sami I Alzarea (SI)

Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf-72341, Saudi Arabia.

Ali Alquraini (A)

Department of Pharmaceutical Chemistry, Faculty of Clinical Pharmacy, Al Baha University, Al Baha 65779, Saudi Arabia.

Gaurav Gupta (G)

Department of Pharmacology, School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, India.
Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Imran Kazmi (I)

Department of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah 21589 Saudi Arabia.

Classifications MeSH