JAK-STAT core cancer pathway: An integrative cancer interactome analysis.
JAK/STAT pathway in cancers
blood cancer
breast cancer
colorectal cancers
liver cancers
lung cancer
protein-protein interactions
systems medicine
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
14
12
2021
received:
25
10
2021
accepted:
22
12
2021
pubmed:
2
3
2022
medline:
8
4
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
Through a comprehensive review and in silico analysis of reported data on STAT-linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for therapeutic intervention to disrupt critical pathways and addictions to hyperactive JAK/STAT in neoplastic states. Although all STATs follow a similar molecular activation pathway, STAT1, STAT2, STAT4 and STAT6 exert specific biological profiles associated with a more restricted pattern of activation by cytokines. STAT3 and STAT5A as well as STAT5B have pleiotropic roles in the body and can act as critical oncogenes that promote many processes involved in cancer development. STAT1, STAT3 and STAT5 also possess tumour suppressive action in certain mutational and cancer type context. Here, we demonstrated member-specific STAT activity in major cancer types. Through systems biology approaches, we found surprising roles for EGFR family members, sex steroid hormone receptor ESR1 interplay with oncogenic STAT function and proposed new drug targeting approaches of oncogenic STAT pathway addiction.
Identifiants
pubmed: 35229974
doi: 10.1111/jcmm.17228
pmc: PMC8980946
doi:
Substances chimiques
Cytokines
0
STAT Transcription Factors
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2049-2062Subventions
Organisme : Austrian Science Fund FWF
ID : I 4157
Pays : Austria
Organisme : European Research Council
Pays : International
Informations de copyright
© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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