Island Study Linking Aging and Neurodegenerative Disease (ISLAND) Targeting Dementia Risk Reduction: Protocol for a Prospective Web-Based Cohort Study.
aging
behavior change
blood-based dementia biomarkers
cognition
dementia
intervention
lifestyle
lifestyle and behaviors
modifiable risk factors
neurodegenerative
older adult
online
prevention
prospective research cohort
public health
research translation
risk
risk reduction
Journal
JMIR research protocols
ISSN: 1929-0748
Titre abrégé: JMIR Res Protoc
Pays: Canada
ID NLM: 101599504
Informations de publication
Date de publication:
01 Mar 2022
01 Mar 2022
Historique:
received:
04
11
2021
accepted:
23
12
2021
revised:
22
12
2021
entrez:
1
3
2022
pubmed:
2
3
2022
medline:
2
3
2022
Statut:
epublish
Résumé
Up to 40% of incident dementia is considered attributable to behavioral and lifestyle factors. Given the current lack of medical treatments and the projected increase in dementia prevalence, a focus on prevention through risk reduction is needed. We aim to increase dementia risk knowledge and promote changes in dementia risk behaviors at individual and population levels. The Island Study Linking Aging and Neurodegenerative Disease (ISLAND) is a long-term prospective, web-based cohort study with nested interventions that will be conducted over a 10-year period. Target participants (n=10,000) reside in Tasmania and are aged 50 years or over. Survey data on knowledge, attitudes, and behaviors related to modifiable dementia risk factors will be collected annually. After each survey wave, participants will be provided with a personalized dementia risk profile containing guidelines for reducing risk across 9 behavioral and lifestyle domains and with opportunities to engage in educational and behavioral interventions targeting risk reduction. Survey data will be modeled longitudinally with intervention engagement indices, cognitive function indices, and blood-based biomarkers, to measure change in risk over time. In the initial 12 months (October 2019 to October 2020), 6410 participants have provided baseline data. The study is ongoing. Recruitment targets are feasible and efforts are ongoing to achieve a representative sample. Findings will inform future public health dementia risk reduction initiatives by showing whether, when, and how dementia risk can be lowered through educational and behavioral interventions, delivered in an uncontrolled real-world context. DERR1-10.2196/34688.
Sections du résumé
BACKGROUND
BACKGROUND
Up to 40% of incident dementia is considered attributable to behavioral and lifestyle factors. Given the current lack of medical treatments and the projected increase in dementia prevalence, a focus on prevention through risk reduction is needed.
OBJECTIVE
OBJECTIVE
We aim to increase dementia risk knowledge and promote changes in dementia risk behaviors at individual and population levels.
METHODS
METHODS
The Island Study Linking Aging and Neurodegenerative Disease (ISLAND) is a long-term prospective, web-based cohort study with nested interventions that will be conducted over a 10-year period. Target participants (n=10,000) reside in Tasmania and are aged 50 years or over. Survey data on knowledge, attitudes, and behaviors related to modifiable dementia risk factors will be collected annually. After each survey wave, participants will be provided with a personalized dementia risk profile containing guidelines for reducing risk across 9 behavioral and lifestyle domains and with opportunities to engage in educational and behavioral interventions targeting risk reduction. Survey data will be modeled longitudinally with intervention engagement indices, cognitive function indices, and blood-based biomarkers, to measure change in risk over time.
RESULTS
RESULTS
In the initial 12 months (October 2019 to October 2020), 6410 participants have provided baseline data. The study is ongoing.
CONCLUSIONS
CONCLUSIONS
Recruitment targets are feasible and efforts are ongoing to achieve a representative sample. Findings will inform future public health dementia risk reduction initiatives by showing whether, when, and how dementia risk can be lowered through educational and behavioral interventions, delivered in an uncontrolled real-world context.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)
UNASSIGNED
DERR1-10.2196/34688.
Identifiants
pubmed: 35230251
pii: v11i3e34688
doi: 10.2196/34688
pmc: PMC8924774
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e34688Informations de copyright
©Larissa Bartlett, Kathleen Doherty, Maree Farrow, Sarang Kim, Edward Hill, Anna King, Jane Alty, Claire Eccleston, Alex Kitsos, Aidan Bindoff, James C Vickers. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 01.03.2022.
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