Comprehensive clinical and virological characterization of three cases of fulminant liver failure owing to HSV1 primary infection.
IM-250
acute liver failure
acyclovir
herpes simplex virus primary infection
pritelivir
viral hepatitis
Journal
Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
Titre abrégé: Liver Int
Pays: United States
ID NLM: 101160857
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
23
12
2021
received:
10
08
2021
accepted:
16
01
2022
pubmed:
2
3
2022
medline:
26
4
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
Herpes simplex virus 1 (HSV-1) is a frequently unrecognized, yet deadly cause of acute liver failure (ALF). We, therefore, analysed three cases of fatal HSV-1-induced ALF. All patients shared clinical (extremely elevated transaminases, LDH and AST/LDH ratio < 1) and virological characteristics (ratio of viral load in plasma versus throat swabs: 60-700-fold, lack of anti-HSV-1-IgG antibodies or low IgG-avidity during primary infection), which may help to identify patients at risk. Additionally, in vitro chemosusceptibility assays revealed high efficacy of the helicase-primase inhibitors (HPI), pritelivir and drug-candidate IM-250 compared to acyclovir (ACV) using HSV-1-isolates from two patients; hence, ACV/HPI-combinations might offer new therapeutic options for HSV-induced ALF.
Substances chimiques
Antiviral Agents
0
Immunoglobulin G
0
Pyridines
0
DNA Primase
EC 2.7.7.-
DNA Helicases
EC 3.6.4.-
Acyclovir
X4HES1O11F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1005-1011Informations de copyright
© 2022 The Authors. Liver International published by John Wiley & Sons Ltd.
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