Trophoblast inclusions and adverse birth outcomes.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
09
2021
accepted:
15
02
2022
entrez:
1
3
2022
pubmed:
2
3
2022
medline:
15
4
2022
Statut:
epublish
Résumé
Trophoblast inclusions-cross sections of abnormal trophoblast bilayer infoldings-have previously been associated with aneuploidy, placenta accreta, and prematurity. This study was conducted to establish the relationship between trophoblast inclusions and a range of placental, pregnancy, and birth outcomes in a patient population with high smoking and alcohol exposure. Specifically, we sought to evaluate the association between the presence of trophoblast inclusions and 1) three primary birth outcomes: full-term birth, preterm birth, and stillbirth; 2) gestational age at delivery; and 3) specific placental pathologies. Two slides containing chorionic villi were evaluated from 589 placentas that were collected from Stellenbosch University in Cape Town, South Africa as part of the prospective, multicenter cohort Safe Passage Study of the Prenatal Alcohol and SIDS and Stillbirth Network. The subsample included 307 full-term live births, 212 preterm live births, and 70 stillbirths. We found that the odds of identifying at least one trophoblast inclusion across two slides of chorionic villi was significantly higher for placentas from preterm compared to term liveborn deliveries (OR = 1.74; 95% CI: 1.22, 2.49, p = 0.002), with an even greater odds ratio for placentas from stillborn compared to term liveborn deliveries (OR = 4.95; 95% CI: 2.78, 8.80, p < 0.001). Gestational age at delivery was inversely associated with trophoblast inclusion frequency. Trophoblast inclusions were significantly associated with small for gestational age birthweight, induction of labor, villous edema, placental infarction, and inflammation of the chorionic plate. The novel associations that we report warrant further investigation in order to understand the complex network of biological mechanisms through which the factors that lead to trophoblast inclusions may influence or reflect the trajectory and health of a pregnancy. Ultimately, this line of research may provide critical insights that could inform both clinical and research applications.
Identifiants
pubmed: 35231069
doi: 10.1371/journal.pone.0264733
pii: PONE-D-21-31280
pmc: PMC8887719
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0264733Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NICHD NIH HHS
ID : L40 HD099886
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD055155
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA016501
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD045935
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD103910
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD055154
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD045991
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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