Bacterial-fungal interactions and their impact on microbial pathogenesis.
bacteria
fungi
microbial biology
species interactions
Journal
Molecular ecology
ISSN: 1365-294X
Titre abrégé: Mol Ecol
Pays: England
ID NLM: 9214478
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
14
01
2022
received:
29
10
2021
accepted:
18
02
2022
medline:
10
5
2023
pubmed:
2
3
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
Microbial communities of the human microbiota exhibit diverse effects on human health and disease. Microbial homeostasis is important for normal physiological functions and changes to the microbiota are associated with many human diseases including diabetes, cancer, and colitis. In addition, there are many microorganisms that are either commensal or acquired from environmental reservoirs that can cause diverse pathologies. Importantly, the balance between health and disease is intricately connected to how members of the microbiota interact and affect one another's growth and pathogenicity. However, the mechanisms that govern these interactions are only beginning to be understood. In this review, we outline bacterial-fungal interactions in the human body, including examining the mechanisms by which bacteria govern fungal growth and virulence, as well as how fungi regulate bacterial pathogenesis. We summarize advances in the understanding of chemical, physical, and protein-based interactions, and their role in exacerbating or impeding human disease. We focus on the three fungal species responsible for the majority of systemic fungal infections in humans: Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. We conclude by summarizing recent studies that have mined microbes for novel antimicrobials and antivirulence factors, highlighting the potential of the human microbiota as a rich resource for small molecule discovery.
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2565-2581Subventions
Organisme : NIH HHS
ID : 1R01AI127375
Pays : United States
Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
Abdulkareem, A. F., Lee, H. H., Ahmadi, M., & Martinez, L. R. (2015). Fungal serotype-specific differences in bacterial-yeast interactions. Virulence, 6, 652-657. https://doi.org/10.1080/21505594.2015.1066962
Abou-Gabal, M., & Atia, M. (1978). Study of the role of pigeons in the dissemination of Cryptococcus neoformans in nature. Sabouraudia, 16, 63-68.
Adnani, N., Rajski, S. R., & Bugni, T. S. (2017). Symbiosis-inspired approaches to antibiotic discovery. Natural Products Reports, 34, 784-814.
Allonsius, C. N., Vandenheuvel, D., Oerlemans, E. F. M., Petrova, M. I., Donders, G. G. G., Cos, P., Delputte, P., & Lebeer, S. (2019). Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG. Scientific Reports, 9, 2900.
Alves, R., Barata-Antunes, C., Casal, M., Brown, A. J. P., Van Dijck, P., & Paiva, S. (2020). Adapting to survive: How Candida overcomes host-imposed constraints during human colonization. PLoS Path, 16, e1008478.
Andes, D., Nett, J., Oschel, P., Albrecht, R., Marchillo, K., & Pitula, A. (2004). Development and characterization of an in vivo central venous catheter Candida albicans biofilm model. Infection and Immunity, 72, 6023-6031.
Arnon, S. S., Schechter, R., Maslanka, S. E., Jewell, N. P., & Hatheway, C. L. (2009). Human botulism immune globulin for the treatment of infant botulism. New England Journal of Medicine, 354, 462-471.
Askew, D. S. (2008). Aspergillus fumigatus: Virulence genes in a street-smart mold. Current Opinion in Microbiology, 11, 331-337. https://doi.org/10.1016/j.mib.2008.05.009
Bachtiar, E. W., Bachtiar, B. M., Jarosz, L. M., Amir, L. R., Sunarto, H., Ganin, H., Meijler, M. M., & Krom, B. P. (2014). AI-2 of Aggregatibacter actinomycetemcomitans inhibits Candida albicans biofilm formation. Frontiers in Cellular and Infection Microbiology, 4, 1-8.
Balhara, M., Ruhil, S., Kumar, M., Dhankhar, S., & Chhillar, A. K. (2014). An anti-Aspergillus protein from Escherichia coli DH5α: Putative inhibitor of siderophore biosynthesis in Aspergillus fumigatus. Mycoses, 57, 153-162.
Ballou, E. R., Avelar, G. M., Childers, D. S., Mackie, J., Bain, J. M., Wagener, J., Kastora, S. L., Panea, M. D., Hardison, S. E., Walker, L. A., Erwig, L. P., Munro, C. A., Gow, N. A., Brown, G. D., MacCallum, D. M., & Brown, A. J. (2017). Lactate signalling regulates fungal β-glucan masking and immune evasion. Nature Microbiology, 2, 16238.
Bamford, C. V., d'Mello, A., Nobbs, A. H., Dutton, L. C., Vickerman, M. M., & Jenkinson, H. F. (2009). Streptococcus gordonii modulates Candida albicans biofilm formation through intergeneric communication. Infection and Immunity, 77, 3696-3704.
Bandara, H. M. H. N., Cheung, B. P. K., Watt, R. M., Jin, L. J., & Samaranayake, L. P. (2013). Secretory products of Escherichia coli biofilm modulate Candida biofilm formation and hyphal development. Journal of Investigative and Clinical Dentistry, 4, 186-199.
Bandara, H. M. H. N., Wood, D. L. A., Vanwonterghem, I., Hugenholtz, P., Cheung, B. P. K., & Samaranayake, L. P. (2020). Fluconazole resistance in Candida albicans is induced by Pseudomonas aeruginosa quorum sensing. Scientific Reports, 10, 1-17.
Barousse, M. M., Van Der Pol, B. J., Fortenberry, D., Orr, D., & Fidel, P. L. (2004). Vaginal yeast colonisation, prevalence of vaginitis, and associated local immunity in adolescents. Sexually Transmitted Infections, 80, 48-53. https://doi.org/10.1136/sti.2002.003855
Belkaid, Y., & Hand, T. W. (2014). Role of the microbiota in immunity and inflammation. Cell, 157, 121-141. https://doi.org/10.1016/j.cell.2014.03.011
Bertolini, M., Ranjan, A., Thompson, A., Diaz, P. I., Sobue, T., Maas, K., & Dongari-Bagtzoglou, A. (2019). Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection. PLoS Path, 15, e1007717.
Berube, B. J., Rangel, S. M., & Hauser, A. R. (2016). Pseudomonas aeruginosa: Breaking down barriers. Current Genetics, 62, 109-113.
Blin, K., Wolf, T., Chevrette, M. G., Lu, X., Schwalen, C. J., Kautsar, S. A., Suarez Duran, H. G., de Los Santos, E. L. C., Kim, H. U., Nave, M., Dickschat, J. S., Mitchell, D. A., Shelest, E., Breitling, R., Takano, E., Lee, S. Y., Weber, T., & Medema, M. H. (2017). antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification. Nucleic Acids Research, 45, 36-41. https://doi.org/10.1093/nar/gkx319
Boon, C., Deng, Y., Wang, L. H., He, Y., Xu, J. L., Fan, Y., Pan, S. Q., & Zhang, L. H. (2008). A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. ISME Journal, 2, 27-36. https://doi.org/10.1038/ismej.2007.76
Bottery, M. J., Pitchford, J. W., & Friman, V.-P. (2020). Ecology and evolution of antimicrobial resistance in bacterial communities. ISME Journal, 15, 939-948.
Bradford, L. L., & Ravel, J. (2017). The vaginal mycobiome: A contemporary perspective on fungi in women’s health and diseases. Virulence, 8, 342-351. https://doi.org/10.1080/21505594.2016.1237332
Briard, B., Heddergott, C., & Latge, J.-P. (2016). Volatile compounds emitted by Pseudomonas aeruginosa stimulate growth of the fungal pathogen Aspergillus fumigatus. MBio, 7, e00219. https://doi.org/10.1128/mBio.00219-16
Briard, B., Mislin, G. L. A., Latgé, J. P. J. P., & Beauvais, A. (2019). Interactions between Aspergillus fumigatus and pulmonary bacteria: Current state of the field, new data, and future perspective. Journal of Fungi, 5, 48.
Brown, A. J., Budge, S., Kaloriti, D., Tillmann, A., Jacobsen, M. D., Yin, Z., Ene, I. V., Bohovych, I., Sandai, D., Kastora, S., Potrykus, J., Ballou, E. R., Childers, D. S., Shahana, S., & Leach, M. D. (2014). Stress adaptation in a pathogenic fungus. Journal of Experimental Biology, 217, 144-155.
Brown, A. O., Graham, C. E., Cruz, M. R., Singh, K. V., Murray, B. E., Lorenz, M. C., & Garsin, D. A. (2019). Antifungal activity of the Enterococcus faecalis peptide EntV requires protease cleavage and disulfide bond formation. MBio, 10, e01334-19. https://doi.org/10.1128/mBio.01334-19
Brown, G. D., Denning, D. W., Gow, N. A., Levitz, S. M., Netea, M. G., & White, T. C. (2012). Hidden killers: Human fungal infections. Science Translational Medicine, 4, 165rv13.
Cabral, D. J., Penumutchu, S., Norris, C., Morones-Ramirez, J. R., & Belenky, P. (2018). Microbial competition between Escherichia coli and Candida albicans reveals a soluble fungicidal factor. Microb. Cell, 5, 249-255.
Calderone, R. A., & Fonzi, W. A. (2001). Virulence factors of Candida albicans. Trends in Microbiology, 9, 327-335.
Camacho, E., Vij, R., Chrissian, C., Prados-Rosales, R., Gil, D., O'Meally, R. N., Cordero, R. J. B., Cole, R. N., McCaffery, J. M., Stark, R. E., & Casadevall, A. (2019). The structural unit of melanin in the cell wall of the fungal pathogen Cryptococcus neoformans. Journal of Biological Chemistry, 294, 10471-10489.
Carlson, E. (1982). Synergistic effect of Candida albicans and Staphylococcus aureus on mouse mortality. Infection and Immunity, 38, 921-924. https://doi.org/10.1128/iai.38.3.921-924.1982
Caruso, R., Lo, B. C., & Núñez, G. (2020). Host-microbiota interactions in inflammatory bowel disease. Nature Reviews Immunology, 20, 411-426.
Cassone, A. (2015). Vulvovaginal Candida albicans infections: Pathogenesis, immunity and vaccine prospects. BJOG, 122, 785-794.
Castagliuolo, I., LaMont, J. T., Nikulasson, S. T., & Pothoulakis, C. (1996). Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infection and Immunity, 64, 5225-5232.
Clardy, J., Fischbach, M. A., & Currie, C. (2009). R The natural history of antibiotics. Current Biology, 19, R437-R441. https://doi.org/10.1016/j.cub.2009.04.001
Clatworthy, A. E., Pierson, E., & Hung, D. T. (2007). Targeting virulence: A new paradigm for antimicrobial therapy. Nature Chemical Biology, 3, 541-548.
Costa, T. R., Felisberto-Rodrigues, C., Meir, A., Prevost, M. S., Redzej, A., Trokter, M., & Waksman, G. (2015). Secretion systems in Gram-negative bacteria: Structural and mechanistic insights. Nature Reviews Microbiology, 13, 343-359.
Coyte, K. Z., Schluter, J., & Foster, K. R. (2015). The ecology of the microbiome: Networks, competition, and stability. Science, 350, 663-666. https://doi.org/10.1126/science.aad2602
Cruz, M. R., Graham, C. E., Gagliano, B. C., Lorenz, M. C., & Garsin, D. A. (2013). Enterococcus faecalis inhibits hyphal morphogenesis and virulence of Candida albicans. Infection and Immunity, 81, 189-200.
Cugini, C., Calfee, M. W., Farrow, J. M. 3rd, Morales, D. K., Pesci, E. C., & Hogan, D. A. (2007). Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. Molecular Microbiology, 65, 896-906.
Cugini, C., Morales, D. K., & Hogan, D. A. (2010). Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. Microbiology, 156, 3096-3107. https://doi.org/10.1099/mic.0.037911-0
Cui, J., Ren, B., Tong, Y., Dai, H., & Zhang, L. (2015). Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans. Virulence, 6, 362-371.
Culp, E. J., Waglechner, N., Wang, W., Fiebig-Comyn, A. A., Hsu, Y. P., Koteva, K., Sychantha, D., Coombes, B. K., Van Nieuwenhze, M. S., Brun, Y. V., & Wright, G. D. (2020). Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature, 578, 582-587. https://doi.org/10.1038/s41586-020-1990-9
Culp, E. J., Yim, G., Waglechner, N., Wang, W., Pawlowski, A. C., & Wright, G. D. (2019). Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics. Nature Biotechnology, 37, 1149-1154.
d’Enfert, C. (2009). Hidden killers: Persistence of opportunistic fungal pathogens in the human host. Current Opinion in Microbiology, 12, 358-364. https://doi.org/10.1016/j.mib.2009.05.008
Dambuza, I. M., Drake, T., Chapuis, A., Zhou, X., Correia, J., Taylor-Smith, L., LeGrave, N., Rasmussen, T., Fisher, M. C., Bicanic, T., Harrison, T. S., Jaspars, M., May, R. C., Brown, G. D., Yuecel, R., MacCallum, D. M., & Ballou, E. R. (2018). The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis. PLoS Path, 14, e1006978.
de Sousa, H. R., de Frazao, S.., de Oliveira Jr., G. P., Albuquerque, P., & Nicola, A. M. (2021). Cryptococcal virulence in humans: Learning from translational studies with clinical isolates. Frontiers in Cellular and Infection Microbiology, 11, 657502.
d'Enfert, C., Kaune, A. K., Alaban, L. R., Chakraborty, S., Cole, N., Delavy, M., Kosmala, D., Marsaux, B., Fróis-Martins, R., Morelli, M., Rosati, D., Valentine, M., Xie, Z., Emritloll, Y., Warn, P. A., Bequet, F., Bougnoux, M. E., Bornes, S., Gresnigt, M. S., … Brown, A. J. P. (2021). The impact of the fungus-host-microbiota interplay upon Candida albicans infections: Current knowledge and new perspectives. FEMS Microbiology Reviews, 45, fuaa060.
Deng, W., Puente, J. L., Gruenheid, S., Li, Y., Vallance, B. A., Vázquez, A., Barba, J., Ibarra, J. A., O'Donnell, P., Metalnikov, P., Ashman, K., Lee, S., Goode, D., Pawson, T., & Finlay, B. B. (2004). Dissecting virulence: Systematic and functional analyses of a pathogenicity island. Proceedings of the National Academy of Sciences of the United States of America, 101, 3597-3602. https://doi.org/10.1073/pnas.0400326101
Dhamgaye, S., Qu, Y., & Peleg, A. Y. (2016). Polymicrobial infections involving clinically relevant Gram-negative bacteria and fungi. Cellular Microbiology, 18, 1716-1722.
Dickey, S. W., Cheung, G. Y. C., & Otto, M. (2017). Different drugs for bad bugs: Antivirulence strategies in the age of antibiotic resistance. Nat. Rev. Drug Discov, 16, 457-471.
Dicks, L. M. T., Mikkelsen, L. S., Brandsborg, E., & Marcotte, H. (2019). Clostridium difficile, the difficult “Kloster” fuelled by antibiotics. Current Microbiology, 76, 774-782.
Edwards, J. E. Jr, Schwartz, M. M., Schmidt, C. S., Sobel, J. D., Nyirjesy, P., Schodel, F., Marchus, E., Lizakowski, M., DeMontigny, E. A., Hoeg, J., Holmberg, T., Cooke, M. T., Hoover, K., Edwards, L., Jacobs, M., Sussman, S., Augenbraun, M., Drusano, M., Yeaman, M. R., … Hennessey, J. P. Jr (2018). A fungal immunotherapeutic vaccine (NDV-3A) for treatment of recurrent ulvovaginal candidiasis-A phase 2 randomized, double-blind, placebo-controlled trial. Clinical Infectious Diseases, 66, 1928-1936.
Fazly, A., Jain, C., Dehner, A. C., Issi, L., Lilly, E. A., Ali, A., Cao, H., Fidel, P. L. Jr, Rao, R. P., & Kaufman, P. D. (2013). Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110, 13594-13599.
Ferretti, P., Pasolli, E., Tett, A., Asnicar, F., Gorfer, V., Fedi, S., Armanini, F., Truong, D. T., Manara, S., Zolfo, M., Beghini, F., Bertorelli, R., De Sanctis, V., Bariletti, I., Canto, R., Clementi, R., Cologna, M., Crifò, T., Cusumano, G., … Segata, N. (2018). Mother-to-infant microbial transmission from different body sites shapes the developing infant gut microbiome. Cell Host & Microbe, 24, 133-145. https://doi.org/10.1016/j.chom.2018.06.005
Fisher, M. C., Gurr, S. J., Cuomo, C. A., Blehert, D. S., Jin, H., Stukenbrock, E. H., Stajich, J. E., Kahmann, R., Boone, C., Denning, D. W., Gow, N. A. R., Klein, B. S., Kronstad, J. W., Sheppard, D. C., Taylor, J. W., Wright, G. D., Heitman, J., Casadevall, A., & Cowen, L. E. (2020). Threats posed by the fungal kingdom to humans, wildlife, and agriculture. MBio, 11, e00449-20.
Fisher, M. C., Hawkins, N. J., Sanglard, D., & Gurr, S. J. (2018). Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science, 360, 739-742. https://doi.org/10.1126/science.aap7999
Förster, T. M., Mogavero, S., Dräger, A., Graf, K., Polke, M., Jacobsen, I. D., & Hube, B. (2016). Enemies and brothers in arms: Candida albicans and gram-positive bacteria. Cellular Microbiology, 18, 1709-1715.
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2014). Adhesion, invasion and evasion: The many functions of the surface proteins of Staphylococcus aureus. Nature Reviews Microbiology, 12, 49-62.
Fox, E. P., Cowley, E. S., Nobile, C. J., Hartooni, N., Newman, D. K., & Johnson, A. D. (2014). Anaerobic bacteria grow within Candida albicans biofilms and induce biofilm formation in suspension cultures. Current Biology, 24, 2411-2416.
Foxman, B., Barlow, R., D’Arcy, H., Gillespie, B., & Sobel, J. D. (2000). Candida vaginitis: Self-reported incidence and associated costs. Sexually Transmitted Diseases, 27, 230-235.
Frases, S., Chaskes, S., Dadachova, E., & Casadevall, A. (2006). Induction by Klebsiella aerogenes of a melanin-like pigment in Cryptococcus neoformans. Applied and Environment Microbiology, 72, 1542-1550.
Garcia, C., Burgain, A., Chaillot, J., Pic, É., Khemiri, I., & Sellam, A. (2018). A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion. Scientific Reports, 8, 1-15.
Gibson, J., Sood, A., & Hogan, D. A. (2009). Pseudomonas aeruginosa-Candida albicans interactions: Localization and fungal toxicity of a phenazine derivative. Applied and Environment Microbiology, 75, 504-513.
Graham, C. E., Cruz, M. R., Garsin, D. A., & Lorenz, M. C. (2017). Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 114, 4507-4512.
Granillo, A. R., Canales, M. G., Espíndola, M. E., Martínez Rivera, M. A., de Lucio, V. M., & Tovar, A. V. (2015). Antibiosis interaction of Staphylococccus aureus on Aspergillus fumigatus assessed in vitro by mixed biofilm formation. BMC Microbiology, 15, 33.
Greenberg, S. S., Zhao, X., Hua, L., Wang, J. F., Nelson, S., & Ouyang, J. (1999). Ethanol inhibits lung clearance of Pseudomonas aeruginosa by a neutrophil and nitric oxide-dependent mechanism, in vivo. Alcoholism, Clinical and Experimental Research, 23, 735-744. https://doi.org/10.1111/j.1530-0277.1999.tb04177.x
Guarino, A., Guandalini, S., & Vecchio, A. L. (2015). Probiotics for prevention and treatment of diarrhea. Journal of Clinical Gastroenterology, 49, 37-45.
Guinan, J., Wang, S., Hazbun, T. R., Yadav, H., & Thangamani, S. (2019). Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans. Scientific Reports, 9, 8872.
Helmink, B. A., Khan, M. A. W., Hermann, A., Gopalakrishnan, V., & Wargo, J. A. (2019). The microbiome, cancer, and cancer therapy. Nature Medicine, 25, 377-388.
Hogan, D. A., & Kolter, R. (2002). Pseudomonas-Candida interactions: An ecological role for virulence factors. Science, 296, 2229-2232.
Hogan, D. A., Vik, Å., & Kolter, R. (2004). A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. Molecular Microbiology, 54, 1212-1223.
Holcombe, L. J., McAlester, G., Munro, C. A., Enjalbert, B., Brown, A. J. P., Gow, N. A. R., Ding, C., Butler, G., O'Gara, F., & Morrissey, J. P. (2010). Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans. Microbiology, 156, 1476-1485. https://doi.org/10.1099/mic.0.037549-0
Ibrahim, A. S., Luo, G., Gebremariam, T., Lee, H., Schmidt, C. S., Hennessey, J. P. Jr, French, S. W., Yeaman, M. R., Filler, S. G., & Edwards, J. E. Jr (2013). NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response. Vaccine, 31, 5549-5556. https://doi.org/10.1016/j.vaccine.2013.09.016
Ibrahim, A. S., Spellberg, B. J., Avanesian, V., Fu, Y., & Edwards, J. E. Jr (2006). The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis. Infection and Immunity, 74, 3039-3041.
Iyer, K. R., Revie, N. M., Fu, C., Robbins, N., & Cowen, L. E. (2021). Treatment strategies for cryptococcal infection: Challenges, advances and future outlook. Nature Reviews Microbiology, 19, 454-466.
Jack, A. A., Daniels, D. E., Jepson, M. A., Vickerman, M. M., Lamont, R. J., Jenkinson, H. F., & Nobbs, A. H. (2015). Streptococcus gordonii comCDE (competence) operon modulates biofilm formation with Candida albicans. Microbiology, 161, 411-421. https://doi.org/10.1099/mic.0.000010
Jang, S. J., Lee, K., Kwon, B., You, H. J., & Ko, G. (2019). Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans. Scientific Reports, 9, 8121.
Jeffery, I. B., O'Herlihy, E. O., Shanahan, F., & O'Toole, P. W. (2020). Microbiome alterations in IBS. Gut, 69, 2263-2264. https://doi.org/10.1136/gutjnl-2020-320919
Jenkinson, H. F., Lala, H. C., & Shepherd, M. G. (1990). Coaggregation of Streptococcus sanguis and other streptococci with Candida albicans. Infection and Immunity, 58, 1429-1436.
Joyner, P. M., Liu, J., Zhang, Z., Merritt, J., Qi, F., & Cichewicz, R. H. (2010). Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. Organic & Biomolecular Chemistry, 8, 5486-5489. https://doi.org/10.1039/c0ob00579g
Kaewsrichan, J., Peeyananjarassri, K., & Kongprasertkit, J. (2006). Selection and identification of anaerobic lactobacilli producing inhibitory compounds against vaginal pathogens. FEMS Immunology and Medical Microbiology, 48, 75-83.
Kalia, N., Singh, J., & Kaur, M. (2020). Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: A critical review. Annals of Clinical Microbiology and Antimicrobials, 19, 5. https://doi.org/10.1186/s12941-020-0347-4
Kapitan, M., Niemiec, M. J., Steimle, A., Frick, J. S., & Jacobsen, I. D. (2019). Fungi as part of the microbiota and interactions with intestinal bacteria. Current Topics in Microbiology and Immunology, 422, 265-301.
Kehe, J., Ortiz, A., Kulesa, A., Gore, J., Blainey, P. C., & Friedman, J. (2021). Positive interactions are common among culturable bacteria. Sci. Adv, 7, 7159.
Kerr, J. R., Taylor, G. W., Rutman, A., Høiby, N., Cole, P. J., & Wilson, R. (1999). Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine inhibit fungal growth. Journal of Clinical Pathology, 52, 385-387. https://doi.org/10.1136/jcp.52.5.385
Khan, Z. U., Pal, M., Randhawa, H. S., & Sandhu, R. S. (1978). Carriage of Cryptococcus neoformans in the crops of pigeons. Journal of Medical Microbiology, 11, 215-218.
Kim, D., Sengupta, A., Niepa, T. H., Lee, B. H., Weljie, A., Freitas-Blanco, V. S., Murata, R. M., Stebe, K. J., Lee, D., & Koo, H. (2017). Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites. Scientific Reports, 7, 41332.
Kim, S. H., Clark, S. T., Surendra, A., Copeland, J. K., Wang, P. W., Ammar, R., Collins, C., Tullis, D. E., Nislow, C., Hwang, D. M., Guttman, D. S., & Cowen, L. E. (2015). Global analysis of the fungal microbiome in cystic fibrosis patients reveals loss of function of the transcriptional repressor Nrg1 as a mechanism of pathogen adaptation. PLoS Path, 11, e1005308.
Kim, Y., & Mylonakis, E. (2011). Killing of Candida albicans filaments by Salmonella enterica serovar Typhimurium is mediated by sopB effectors, parts of a type III secretion system. Eukaryotic Cell, 10, 782-790.
Klotz, S. A., Chasin, B. S., Powell, B., Gaur, N. K., & Lipke, P. N. (2007). Polymicrobial bloodstream infections involving Candida species: Analysis of patients and review of the literature. Diagnostic Microbiology and Infectious Disease, 59, 401-406.
Kong, E. F., Tsui, C., Kucharikova, S., Van Dijck, P., & Jabra-Rizk, M. A. (2017). Modulation of Staphylococcus aureus response to antimicrobials by the Candida albicans quorum sensing molecule farnesol. Antimicrobial Agents and Chemotherapy, 61, e01573-e1617. https://doi.org/10.1128/AAC.01573-17
Kruger, W., Vielreicher, S., Kapitan, M., Jacobsen, I. D., & Niemiec, M. J. (2019). Fungal-bacterial interactions in health and disease. Pathogens, 8, 70. https://doi.org/10.3390/pathogens8020070
Kumamoto, C. A., Gresnigt, M. S., & Hube, B. (2020). The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine. Current Opinion in Microbiology, 56, 7-15.
Kumari, A., & Singh, R. (2019). Medically important interactions of staphylococci with pathogenic fungi. Future Microbiology, 14, 1159-1170.
Kwak, M.-K., Liu, R., Kim, M. K., Moon, D., Kim, A. H., Song, S. H., & Kang, S. O. (2014). Cyclic dipeptides from lactic acid bacteria inhibit the proliferation of pathogenic fungi. J. Microbiol, 52, 64-70. https://doi.org/10.1007/s12275-014-3520-7
Kwon-Chung, K. J., Fraser, J. A., Doering, T. L., Wang, Z., Janbon, G., Idnurm, A., & Bahn, Y. S. (2014). Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis. Cold Spring Harbor Perspectives in Medicine, 4, a019760. https://doi.org/10.1101/cshperspect.a019760
Lalla, R. V., Latortue, M. C., Hong, C. H., Ariyawardana, A., D'Amato-Palumbo, S., Fischer, D. J., Martof, A., Nicolatou-Galitis, O., Patton, L. L., Elting, L. S., Spijkervet, F. K., & Brennan, M. T. (2010). Fungal Infections Section, Oral Care Study Group. A systematic review of oral fungal infections in patients receiving cancer therapy. Supportive Care in Cancer, 18, 985-992. https://doi.org/10.1007/s00520-010-0892-z
Li, J., Chen, D., Yu, B., He, J., Zheng, P., Mao, X., Yu, J., Luo, J., Tian, G., Huang, Z., & Luo, Y. (2018). Fungi in gastrointestinal tracts of human and mice: From community to functions. Microbial Ecology, 75, 821-829. https://doi.org/10.1007/s00248-017-1105-9
Li, Y. F., Tsai, K. J. S., Harvey, C. J. B., Li, J. J., Ary, B. E., Berlew, E. E., Boehman, B. L., Findley, D. M., Friant, A. G., Gardner, C. A., Gould, M. P., Ha, J. H., Lilley, B. K., McKinstry, E. L., Nawal, S., Parry, R. C., Rothchild, K. W., Silbert, S. D., Tentilucci, M. D., … Charkoudian, L. K. (2016). Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products. Fungal Genetics and Biology, 89, 18-28.
Liang, W., Guan, G., Dai, Y., Cao, C., Tao, L., Du, H., Nobile, C. J., Zhong, J., & Huang, G. (2016). Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans. Molecular Microbiology, 102, 506-519.
Limon, J. J., Skalski, J. H., & Underhill, D. M. (2017). Commensal fungi in health and disease. Cell Host & Microbe, 22, 156-165. https://doi.org/10.1016/j.chom.2017.07.002
Lindsay, A. K., Morales, D. K., Liu, Z., Grahl, N., Zhang, A., Willger, S. D., Myers, L. C., & Hogan, D. A. (2014). Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation. PLoS Genetics, 10, e1004567.
Liu, H. Y., Li, C. X., Liang, Z. Y., Zhang, S. Y., Yang, W. Y., Ye, Y. M., Lin, Y. X., Chen, R. C., Zhou, H. W., & Su, J. (2020). The interactions of airway bacterial and fungal communities in clinically stable asthma. Frontiers in Microbiology, 11, 1647.
Lohse, M. B., Gulati, M., Johnson, A. D., & Nobile, C. J. (2017). Development and regulation of single- and multi-species Candida albicans biofilms. Nature Reviews Microbiology, 16, 19-31.
Lopez-Medina, E., Fan, D., Coughlin, L. A., Ho, E. X., Lamont, I. L., Reimmann, C., Hooper, L. V., & Koh, A. Y. (2015). Candida albicans inhibits Pseudomonas aeruginosa virulence through suppression of pyochelin and pyoverdine biosynthesis. PLoS Path, 11, e1005129.
Lourenco, A., Pedro, N. A., Salazar, S. B., & Mira, N. P. (2019). Effect of acetic acid and lactic acid at low pH in growth and azole resistance of Candida albicans and Candida glabrata. Frontiers in Microbiology, 9, 3265.
MacAlpine, J., Daniel-Ivad, M., Liu, Z., Yano, J., Revie, N. M., Todd, R. T., Stogios, P. J., Sanchez, H., O'Meara, T. R., Tompkins, T. A., Savchenko, A., Selmecki, A., Veri, A. O., Andes, D. R., Fidel, P. L. Jr, Robbins, N., Nodwell, J., Whitesell, L., & Cowen, L. E. (2021). A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase. Nature Communications, 12, 1-16.
Mangan, A. (1969). Interactions between some aural Aspergillus species and bacteria. Journal of General Microbiology, 58, 261-266. https://doi.org/10.1099/00221287-58-2-261
Martens, E., & Demain, A. L. (2017). The antibiotic resistance crisis, with a focus on the United States. Journal of Antibiotics, 70, 520-526.
May, R. C., Stone, N. R. H., Wiesner, D. L., Bicanic, T., & Nielsen, K. (2015). Cryptococcus: from environmental saprophyte to global pathogen. Nature Reviews Microbiology, 14, 106-117.
Mayer, F. L., & Kronstad, J. W. (2017). Disarming fungal pathogens: Bacillus safensis inhibits virulence factor production and biofilm formation by Cryptococcus neoformans and Candida albicans. MBio, 8, e01537-17.
Mayer, F. L., & Kronstad, J. W. (2019). The spectrum of interactions between Cryptococcus neoformans and bacteria. Journal of Fungi, 5, 31. https://doi.org/10.3390/jof5020031
Migone, T. S., Subramanian, G. M., Zhong, J., Healey, L. M., Corey, A., Devalaraja, M., Lo, L., Ullrich, S., Zimmerman, J., Chen, A., Lewis, M., Meister, G., Gillum, K., Sanford, D., Mott, J., & Bolmer, S. D. (2009). Raxibacumab for the treatment of inhalational anthrax. New England Journal of Medicine, 361, 135-144.
Molloy, E. M., & Hertweck, C. (2017). Antimicrobial discovery inspired by ecological interactions. Current Opinion in Microbiology, 39, 121-127.
Moloney, M. G. (2016). Natural products as a source for novel antibiotics. Trends in Pharmacological Sciences, 37, 689-701. https://doi.org/10.1016/j.tips.2016.05.001
Montelongo-Jauregui, D., & Lopez-Ribot, J. L. (2018). Candida interactions with the oral bacterial microbiota. Journal of Fungi, 4, 122. https://doi.org/10.3390/jof4040122
Morales, D. K., Grahl, N., Okegbe, C., Dietrich, L. E., Jacobs, N. J., & Hogan, D. A. (2013). Control of Candida albicans metabolism and biofilm formation by Pseudomonas aeruginosa phenazines. MBio, 4, e00526-12. https://doi.org/10.1128/mBio.00526-12
More, M. I., & Swidsinski, A. (2015). Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis - A review. Clinical and Experimental Gastroenterology, 8, 237-255.
Morse, D. J., Wilson, M. J., Wei, X., Bradshaw, D. J., Lewis, M. A. O., & Williams, D. W. (2019). Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria. Letters in Applied Microbiology, 68, 337-343.
Mould, D. L., & Hogan, D. A. (2021). Intraspecies heterogeneity in microbial interactions. Current Opinion in Microbiology, 62, 14-20. https://doi.org/10.1016/j.mib.2021.04.003
Moura-Alves, P., Faé, K., Houthuys, E., Dorhoi, A., Kreuchwig, A., Furkert, J., Barison, N., Diehl, A., Munder, A., Constant, P., Skrahina, T., Guhlich-Bornhof, U., Klemm, M., Koehler, A. B., Bandermann, S., Goosmann, C., Mollenkopf, H. J., Hurwitz, R., Brinkmann, V., … Kaufmann, S. H. (2014). AhR sensing of bacterial pigments regulates antibacterial defence. Nature, 512, 387-392. https://doi.org/10.1038/nature13684
Moyes, D. L., Wilson, D., Richardson, J. P., Mogavero, S., Tang, S. X., Wernecke, J., Höfs, S., Gratacap, R. L., Robbins, J., Runglall, M., Murciano, C., Blagojevic, M., Thavaraj, S., Förster, T. M., Hebecker, B., Kasper, L., Vizcay, G., Iancu, S. I., Kichik, N., … Naglik, J. R. (2016). Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature, 532, 64-68. https://doi.org/10.1038/nature17625
Nash, E. E., Peters, B. M., Fidel, P. L., & Noverr, M. C. (2015). Morphology-independent virulence of Candida species during polymicrobial intra-abdominal infections with Staphylococcus aureus. Infection and Immunity, 84, 90-98.
Nash, E. E., Peters, B. M., Palmer, G. E., Fidel, P. L., & Noverr, M. C. (2014). Morphogenesis is not required for Candida albicans-Staphylococcus aureus intra-abdominal infection-mediated dissemination and lethal sepsis. Infection and Immunity, 82, 3426-3435.
Nazik, H., Sass, G., Ansari, S. R., Ertekin, R., Haas, H., Déziel, E., & Stevens, D. A. (2020). Novel intermicrobial molecular interaction: Pseudomonas aeruginosa Quinolone Signal (PQS) modulates Aspergillus fumigatus response to iron. Microbiology, 166, 44-55. https://doi.org/10.1099/mic.0.000858
Negrini, T. C., Koo, H., & Arthur, R. A. (2019). Candida-bacterial biofilms and host-microbe interactions in oral diseases. Advances in Experimental Medicine and Biology, 1197, 119-141.
Netea, M. G., Joosten, L. A. B., van der Meer, J. W. M., Kullberg, B.-J., & van de Veerdonk, F. L. (2015). Immune defence against Candida fungal infections. Nature Reviews Immunology, 15, 630-642.
Noble, S. M., French, S., Kohn, L. A., Chen, V., & Johnson, A. D. (2010). Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nature Genetics, 42, 590-598.
Noble, S. M., Gianetti, B. A., & Witchley, J. N. (2017). Candida albicans cell-type switching and functional plasticity in the mammalian host. Nature Reviews Microbiology, 15, 96-108.
Nogueira, F., Sharghi, S., Kuchler, K., & Lion, T. (2019). Pathogenetic impact of bacterial-fungal interactions. Microorganisms, 7, 459. https://doi.org/10.3390/microorganisms7100459
O'Donnell, L. E., Millhouse, E., Sherry, L., Kean, R., Malcolm, J., Nile, C. J., & Ramage, G. (2015). Polymicrobial Candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15, fov077.
Osset, J., García, E., Bartolomé, R. M., & Andreu, A. (2001). Role of Lactobacillus as protector against vaginal candidiasis. Medicina Clínica, 117, 285-288.
Ost, K. S., O'Meara, T. R., Stephens, W. Z., Chiaro, T., Zhou, H., Penman, J., Bell, R., Catanzaro, J. R., Song, D., Singh, S., Call, D. H., Hwang-Wong, E., Hanson, K. E., Valentine, J. F., Christensen, K. A., O'Connell, R. M., Cormack, B., Ibrahim, A. S., Palm, N. W., … Round, J. L. (2021). Adaptive immunity induces mutualism between commensal eukaryotes. Nature, 596, 114-118. https://doi.org/10.1038/s41586-021-03722-w
Padder, S. A., Prasad, R., & Shah, A. H. (2018). Quorum sensing: A less known mode of communication among fungi. Microbiological Research, 210, 51-58.
Paterson, M. J., Oh, S., & Underhill, D. M. (2017). Host-microbe interactions: commensal fungi in the gut. Current Opinion in Microbiology, 40, 131-137.
Patridge, E., Gareiss, P., Kinch, M. S., & Hoyer, D. (2016). An analysis of FDA-approved drugs: natural products and their derivatives. Drug Discovery Today, 21, 204-207.
Peleg, A. Y., Hogan, D. A., & Mylonakis, E. (2010). Medically important bacterial-fungal interactions. Nature Reviews Microbiology, 8, 340-349.
Pendharkar, S., Brandsborg, E., Hammarström, L., Marcotte, H., & Larsson, P.-G. (2015). Vaginal colonisation by probiotic lactobacilli and clinical outcome in women conventionally treated for bacterial vaginosis and yeast infection. BMC Infectious Diseases, 15, 255.
Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M. H., Pappas, P. G., Powderly, W. G., Singh, N., Sobel, J. D., & Sorrell, T. C. (2010). Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clinical Infectious Diseases, 50, 291-322.
Phan, Q. T., Myers, C. L., Fu, Y., Sheppard, D. C., Yeaman, M. R., Welch, W. H., Ibrahim, A. S., Edwards, J. E. Jr, & Filler, S. G. (2007). Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. PLoS Biology, 5, e64.
Pierce, C. G., Chaturvedi, A. K., Lazzell, A. L., Powell, A. T., Saville, S. P., McHardy, S. F., & Lopez-Ribot, J. L. (2015). A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance. Npj Biofilms and Microbiomes, 1, 1-8. https://doi.org/10.1038/npjbiofilms.2015.12
Potterat, O., & Hamburger, M. (2013). Concepts and technologies for tracking bioactive compounds in natural product extracts: Generation of libraries, and hyphenation of analytical processes with bioassays. Natural Products Reports, 30, 546-564.
Rada, B., & Leto, T. L. (2013). Pyocyanin effects on respiratory epithelium: Relevance in Pseudomonas aeruginosa airway infections. Trends in Microbiology, 21, 73-81.
Raffa, N., Won, T. H., Sukowaty, A., Candor, K., Cui, C., Halder, S., Dai, M., Landero-Figueroa, J. A., Schroeder, F. C., & Keller, N. P. (2021). Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity. Proceedings of the National Academy of Sciences of the United States of America, 118, e2015224118.
Rajasingham, R., Smith, R. M., Park, B. J., Jarvis, J. N., Govender, N. P., Chiller, T. M., Denning, D. W., Loyse, A., & Boulware, D. R. (2017). Global burden of disease of HIV-associated cryptococcal meningitis: An updated analysis. The Lancet Infectious Diseases, 17, 873-881.
Ramage, G., Saville, S. P., Wickes, B. L., & López-Ribot, J. L. (2002). Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Applied and Environment Microbiology, 68, 5459-5463.
Reece, E., Doyle, S., Greally, P., Renwick, J., & McClean, S. (2018). Aspergillus fumigatus inhibits Pseudomonas aeruginosa in co-culture: Implications of a mutually antagonistic relationship on virulence and inflammation in the CF airway. Frontiers in Microbiology, 9, 1205.
Rella, A., Yang, M. W., Gruber, J., Montagna, M. T., Luberto, C., Zhang, Y. M., & Del Poeta, M. (2011). Pseudomonas aeruginosa inhibits the growth of Cryptococcus species. Mycopathol, 173, 451-461. https://doi.org/10.1007/s11046-011-9494-7
Roemer, T., Xu, D., Singh, S. B., Parish, C. A., Harris, G., Wang, H., Davies, J. E., & Bills, G. F. (2011). Confronting the challenges of natural product-based antifungal discovery. Chemistry & Biology, 18, 148-164.
Romo, J. A., & Kumamoto, C. A. (2020). On commensalism of Candida. Journal of Fungi, 6, 16. https://doi.org/10.3390/jof6010016
Romo, J. A., Pierce, C. G., Chaturvedi, A. K., Lazzell, A. L., McHardy, S. F., Saville, S. P., & Lopez-Ribot, J. L. (2017). Development of anti-virulence approaches for candidiasis via a novel series of small-molecule inhibitors of Candida albicans filamentation. MBio, 8, e01991-17.
Ruiz, A., Neilson, J. B., & Bulmer, G. S. (1982). Control of Cryptococcus neoformans in nature by biotic factors. Sabouraudia, 20, 21-29.
Saito, F., & Ikeda, R. (2005). Killing of Cryptococcus neoformans by Staphylococcus aureus: The role of cryptococcal capsular polysaccharide in the fungal-bacteria interaction. Medical Mycology, 43, 603-612.
Salvatori, O., Kumar, R., Metcalfe, S., Vickerman, M., Kay, J. G., & Edgerton, M. (2020). Bacteria modify Candida albicans hypha formation, microcolony properties, and survival within macrophages. mSphere, 5, e00689-20.
Santos, C. M. A., Pires, M. C. V., Leão, T. L., Hernández, Z. P., Rodriguez, M. L., Martins, A. K. S., Miranda, L. S., Martins, F. S., & Nicoli, J. R. (2016). Selection of Lactobacillus strains as potential probiotics for vaginitis treatment. Microbiology, 162, 1195-1207. https://doi.org/10.1099/mic.0.000302
Santus, W., Devlin, J. R., & Behnsen, J. (2021). Crossing kingdoms: How the mycobiota and fungal-bacterial interactions impact host health and disease. Infection and Immunity, 89, e00648-e720. https://doi.org/10.1128/IAI.00648-20
Sass, G., Nazik, H., Penner, J., Shah, H., Ansari, S. R., Clemons, K. V., Groleau, M. C., Dietl, A. M., Visca, P., Haas, H., Déziel, E., & Stevens, D. A. (2017). Studies of Pseudomonas aeruginosa mutants indicate pyoverdine as the central factor in inhibition of Aspergillus fumigatus biofilm. Journal of Bacteriology, 200, e00345-e417.
Sass, G., Nazik, H., Penner, J., Shah, H., Ansari, S. R., Clemons, K. V., Groleau, M. C., Dietl, A. M., Visca, P., Haas, H., Déziel, E., & Stevens, D. A. (2019). Aspergillus-Pseudomonas interaction, relevant to competition in airways. Medical Mycology, 57, S228-S232.
Schlecht, L. M., Peters, B. M., Krom, B. P., Freiberg, J. A., Hänsch, G. M., Filler, S. G., Jabra-Rizk, M. A., & Shirtliff, M. E. (2015). Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue. Microbiolgy, 161, 168-181. https://doi.org/10.1099/mic.0.083485-0
Schwabe, R. F., & Jobin, C. (2013). The microbiome and cancer. Nature Reviews Cancer, 13, 800-812.
Seelig, M. S. (1966). Mechanisms by which antibiotics increase the incidence and severity of candidiasis and alter the immunological defenses. Bacteriological Reviews, 30, 442-459. https://doi.org/10.1128/br.30.2.442-459.1966
Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011). Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiology and Molecular Biology Reviews, 75, 213-267.
Shenoy, A., & Gottlieb, A. (2019). Probiotics for oral and vulvovaginal candidiasis: A review. Dermatologic Therapy, 32, e12970.
Spellberg, B., Ibrahim, A. S., Edwards, J. E., & Filler, S. G. (2005). Mice with disseminated candidiasis die of progressive sepsis. Journal of Infectious Diseases, 192, 336-343.
Steffan, B. N., Venkatesh, N., & Keller, N. P. (2020). Let’s get physical: Bacterial-fungal interactions and their consequences in agriculture and health. Journal of Fungi, 6, 243. https://doi.org/10.3390/jof6040243
Swift, C. L., Louie, K. B., Bowen, B. P., Olson, H. M., Purvine, S. O., Salamov, A., Mondo, S. J., Solomon, K. V., Wright, A. T., Northen, T. R., Grigoriev, I. V., Keller, N. P., & O'Malley, M. A. (2021). Anaerobic gut fungi are an untapped reservoir of natural products. Proceedings of the National Academy of Sciences of the United States of America, 118, e2019855118. https://doi.org/10.1073/pnas.2019855118
Szajewska, H., Horvath, A., & Kolodziej, M. (2015). Systematic review with meta-analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection. Alimentary Pharmacology & Therapeutics, 41, 1237-1245.
Thein, Z. M., Samaranayake, Y. H., & Samaranayake, L. P. (2006). Effect of oral bacteria on growth and survival of Candida albicans biofilms. Archives of Oral Biology, 51, 672-680.
Tig, H., & Moschen, A. R. (2014). Microbiota and diabetes: An evolving relationship. Gut, 63, 1513-1521. https://doi.org/10.1136/gutjnl-2014-306928
Todd, O. A., Fidel, P. L. Jr, Harro, J. M., Hilliard, J. J., Tkaczyk, C., Sellman, B. R., Noverr, M. C., & Peters, B. M. (2019). Candida albicans augments Staphylococcus aureus virulence by engaging the Staphylococcal agr Quorum Sensing System. MBio, 10, e00910-19.
Todd, O. A., Noverr, M. C., & Peters, B. M. (2019). Candida albicans impacts Staphylococcus aureus alpha-toxin production via extracellular alkalinization. mSphere, 4, e00780-19. https://doi.org/10.1128/mSphere.00780-19
Tso, G. H. W., Reales-Calderon, J. A., Tan, A. S. M., Sem, X., Le, G. T. T., Tan, T. G., Lai, G. C., Srinivasan, K. G., Yurieva, M., Liao, W., Poidinger, M., Zolezzi, F., Rancati, G., & Pavelka, N. (2018). Experimental evolution of a fungal pathogen into a gut symbiont. Science, 362, 589-595. https://doi.org/10.1126/science.aat0537
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., Egholm, M., Henrissat, B., Heath, A. C., Knight, R., & Gordon, J. I. (2009). A core gut microbiome in obese and lean twins. Nature, 457, 480-484. https://doi.org/10.1038/nature07540
van de Veerdonk, F. L., Gresnigt, M. S., Romani, L., Netea, M. G., & Latge, J.-P. (2017). Aspergillus fumigatus morphology and dynamic host interactions. Nature Reviews Microbiology, 15, 661-674.
van Leeuwen, P. T., van der Peet, J. M., Bikker, F. J., Hoogenkamp, M. A., Oliveira Paiva, A. M., Kostidis, S., Mayboroda, O. A., Smits, W. K., & Krom, B. P. (2016). Interspecies interactions between Clostridium difficile and Candida albicans. mSphere, 1, e00187-16. https://doi.org/10.1128/mSphere.00187-16
Vangay, P., Johnson, A. J., Ward, T. L., Al-Ghalith, G. A., Shields-Cutler, R. R., Hillmann, B. M., Lucas, S. K., Beura, L. K., Thompson, E. A., Till, L. M., Batres, R., Paw, B., Pergament, S. L., Saenyakul, P., Xiong, M., Kim, A. D., Kim, G., Masopust, D., Martens, E. C., … Knights, D. (2018). US immigration Westernizes the human gut microbiome. Cell, 175, 962-972. https://doi.org/10.1016/j.cell.2018.10.029
Vílchez, R., Lemme, A., Ballhausen, B., Thiel, V., Schulz, S., Jansen, R., Sztajer, H., & Wagner-Döbler, I. (2010). Streptococcus mutans inhibits Candida albicans hyphal formation by the fatty acid signaling molecule trans-2-decenoic acid (SDSF). ChemBioChem, 11, 1552-1562. https://doi.org/10.1002/cbic.201000086
Vrbanac, A., Riestra, A. M., Coady, A., Knight, R., Nizet, V., & Patras, K. A. (2018). The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus. BMC Microbiology, 18, 197.
Vu, K., Garcia, J. A., & Gelli, A. (2019). Cryptococcal meningitis and anti-virulence therapeutic strategies. Frontiers in Microbiology, 10, 353.
Wang, F., Xin, C., Liu, J., Ran, Z., Zhao, C., & Song, Z. (2020). Interactions between invasive fungi and symbiotic bacteria. World Journal of Microbiology & Biotechnology, 36, 137.
Wang, S., Wang, Q., Yang, E., Yan, L., Li, T., & Zhuang, H. (2017). Antimicrobial compounds produced by vaginal Lactobacillus crispatus are able to strongly inhibit Candida albicans growth, hyphal formation and regulate virulence-related gene expressions. Frontiers in Microbiology, 8, 564.
Wilcox, M. H., Gerding, D. N., Poxton, I. R., Kelly, C., Nathan, R., Birch, T., Cornely, O. A., Rahav, G., Bouza, E., Lee, C., Jenkin, G., Jensen, W., Kim, Y. S., Yoshida, J., Gabryelski, L., Pedley, A., Eves, K., Tipping, R., Guris, D., … MODIFY I and MODIFY II Investigators. (2017). Bezlotoxumab for prevention of recurrent Clostridium difficile infection. New England Journal of Medicine, 376, 422-423.
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011). Shifting the balance: Antibiotic effects on host-microbiota mutualism. Nature Reviews Microbiology, 9, 233-243.
Witchley, J. N., Penumetcha, P., Abon, N. V., Woolford, C. A., Mitchell, A. P., & Noble, S. M. (2019). Candida albicans morphogenesis programs control the balance between gut commensalism and invasive infection. Cell Host & Microbe, 25, 432-443. https://doi.org/10.1016/j.chom.2019.02.008
Wittaker Leclair, L., & Hogan, D. A. (2010). Mixed bacterial-fungal infections in the CF respiratory tract. Medical Mycology, 48, 125-132.
Xu, H., & Dongari-Bagtzoglou, A. (2015). Shaping the oral mycobiota: Interactions of opportunistic fungi with oral bacteria and the host. Current Opinion in Microbiology, 26, 65-70.
Xu, H., Sobue, T., Thompson, A., Xie, Z., Poon, K., Ricker, A., Cervantes, J., Diaz, P. I., & Dongari-Bagtzoglou, A. (2014). Streptococcal co-infection augments Candida pathogenicity by amplifying the mucosal inflammatory response. Cellular Microbiology, 16, 214-231.
Yu, X.-Y., Fu, F., Kong, W. N., Xuan, Q. K., Wen, D. H., Chen, X. Q., He, Y. M., He, L. H., Guo, J., Zhou, A. P., Xi, Y. H., Ni, L. J., Yao, Y. F., & Wu, W. J. (2018). Streptococcus agalactiae inhibits Candida albicans hyphal development and diminishes host vaginal mucosal TH17 response. Frontiers in Microbiology, 9, 198.
Zhang, F., Zhao, M., Braun, D. R., Ericksen, S. S., Piotrowski, J. S., Nelson, J., Peng, J., Ananiev, G. E., Chanana, S., Barns, K., Fossen, J., Sanchez, H., Chevrette, M. G., Guzei, I. A., Zhao, C., Guo, L., Tang, W., Currie, C. R., Rajski, S. R., … Bugni, T. S. (2020). A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science, 370, 974-978. https://doi.org/10.1126/science.abd6919