Age differences in the functional architecture of the human brain.
connectivity
gradients
multi-echo fMRI
network neuroscience
parcellation
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
15 12 2022
15 12 2022
Historique:
received:
07
11
2021
revised:
04
01
2022
accepted:
26
01
2022
pubmed:
2
3
2022
medline:
21
12
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
The intrinsic functional organization of the brain changes into older adulthood. Age differences are observed at multiple spatial scales, from global reductions in modularity and segregation of distributed brain systems, to network-specific patterns of dedifferentiation. Whether dedifferentiation reflects an inevitable, global shift in brain function with age, circumscribed, experience-dependent changes, or both, is uncertain. We employed a multimethod strategy to interrogate dedifferentiation at multiple spatial scales. Multi-echo (ME) resting-state fMRI was collected in younger (n = 181) and older (n = 120) healthy adults. Cortical parcellation sensitive to individual variation was implemented for precision functional mapping of each participant while preserving group-level parcel and network labels. ME-fMRI processing and gradient mapping identified global and macroscale network differences. Multivariate functional connectivity methods tested for microscale, edge-level differences. Older adults had lower BOLD signal dimensionality, consistent with global network dedifferentiation. Gradients were largely age-invariant. Edge-level analyses revealed discrete, network-specific dedifferentiation patterns in older adults. Visual and somatosensory regions were more integrated within the functional connectome; default and frontoparietal control network regions showed greater connectivity; and the dorsal attention network was more integrated with heteromodal regions. These findings highlight the importance of multiscale, multimethod approaches to characterize the architecture of functional brain aging.
Identifiants
pubmed: 35231927
pii: 6539992
doi: 10.1093/cercor/bhac056
pmc: PMC9758585
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114-134Subventions
Organisme : NIA NIH HHS
ID : R00 AG054573
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS074980
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025145
Pays : United States
Organisme : NIH HHS
ID : 1S10RR025145
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
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