Pancytopenia in a patient treated with fusidic acid and niraparib: a case report.
breast neoplasms
case reports
drug incompatibility
medical oncology
pharmacy service, hospital
Journal
European journal of hospital pharmacy : science and practice
ISSN: 2047-9956
Titre abrégé: Eur J Hosp Pharm
Pays: England
ID NLM: 101578294
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
29
04
2021
accepted:
08
02
2022
medline:
25
8
2023
pubmed:
3
3
2022
entrez:
2
3
2022
Statut:
ppublish
Résumé
Fusidic acid is an antibiotic used in the treatment of staphylococcal infections. Niraparib is an anticancer drug indicated for the treatment of advanced ovarian cancer. The interaction between these two drugs has not been studied and is not referenced in drug databases. We present the case of a patient with pancytopenia who had been treated with fusidic acid and niraparib. No other treatment was taken by this patient. According to the literature, both substances can cause haematological toxicity. It seems unlikely that this is due to niraparib alone because it had been well tolerated by the patient for over a year before the pancytopenia was diagnosed. It was also perfectly well tolerated when it was reintroduced. We cannot determine whether this pancytopenia is due to fusidic acid alone or to a drug interaction between the two treatments. We therefore recommend caution in patients treated with this combination.
Identifiants
pubmed: 35232830
pii: ejhpharm-2021-002819
doi: 10.1136/ejhpharm-2021-002819
pmc: PMC10447960
doi:
Substances chimiques
Fusidic Acid
59XE10C19C
niraparib
HMC2H89N35
Anti-Bacterial Agents
0
Indazoles
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e24Informations de copyright
© European Association of Hospital Pharmacists 2023. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Clin Infect Dis. 2011 Jun;52 Suppl 7:S527-37
pubmed: 21546630
N Engl J Med. 2016 Dec;375(22):2154-2164
pubmed: 27717299
Br J Clin Pharmacol. 2017 May;83(5):1039-1047
pubmed: 27813241
Br J Clin Pharmacol. 2000 Jul;50(1):82-3
pubmed: 10886126
Gynecol Oncol. 2018 Apr;149(1):214-220
pubmed: 29397193