Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
received:
02
08
2021
accepted:
17
02
2022
entrez:
2
3
2022
pubmed:
3
3
2022
medline:
13
4
2022
Statut:
epublish
Résumé
Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious effects on lifespan in Caenorhabditis elegans, while a basal expression of ech-6 was important for survival under normal dietary conditions. Lipidomics revealed that supplementation of fat in ech-6-silenced worms had marginal effects on lipid profiles, suggesting an alternative fat utilization for energy production. Transcriptomics further suggest a causal relation between the lysosomal pathway, energy production, and the longevity effect conferred by the interaction between ech-6 and fat diets. Indeed, enhancing energy production from endogenous fat by overexpressing lysosomal lipase lipl-4 recapitulated the lifespan effects of fat diets on ech-6-silenced worms. Collectively, these results suggest that the gene ech-6 is potential modulator of metabolic flexibility and may be a target for promoting metabolic health and longevity.
Identifiants
pubmed: 35233004
doi: 10.1038/s41598-022-07397-9
pii: 10.1038/s41598-022-07397-9
pmc: PMC8888598
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3350Subventions
Organisme : National Institute of Health
ID : AG042494
Organisme : NIA NIH HHS
ID : R00 AG042494
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG051810
Pays : United States
Informations de copyright
© 2022. The Author(s).
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