Potential role of chitinase-3-like protein 1 (CHI3L1/YKL-40) in neurodegeneration and Alzheimer's disease.
Alzheimer's disease
CHI3L1/YKL-40
biomarker
neurodegeneration
neuroinflammation
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
05
01
2022
received:
01
10
2021
accepted:
07
01
2022
pubmed:
3
3
2022
medline:
18
1
2023
entrez:
2
3
2022
Statut:
ppublish
Résumé
Chitinase-3-like protein 1 (CHI3L1/YKL-40) has long been known as a biomarker for early detection of neuroinflammation and disease diagnosis of Alzheimer's disease (AD). In the brain, CHI3L1 is primarily provided by astrocytes and heralds the reactive, neurotoxic state triggered by inflammation and other stress signals. However, how CHI3L1 acts in neuroinflammation or how it contributes to AD and relevant neurodegenerative conditions remains unknown. In peripheral tissues, our group and others have uncovered that CHI3L1 is a master regulator for a wide range of injury and repair events, including the innate immunity pathway that resembles the neuroinflammation process governed by microglia and astrocytes. Based on assessment of current knowledge regarding CHI3L1 biology, we hypothesize that CHI3L1 functions as a signaling molecule mediating distinct neuroinflammatory responses in brain cells and misfunctions to precipitate neurodegeneration. We also recommend future research directions to validate such assertions for better understanding of disease mechanisms.
Identifiants
pubmed: 35234337
doi: 10.1002/alz.12612
pmc: PMC9437141
mid: NIHMS1785418
doi:
Substances chimiques
Chitinase-3-Like Protein 1
0
Chitinases
EC 3.2.1.14
CHI3L1 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-24Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM136566
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM119943
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG054616
Pays : United States
Informations de copyright
© 2022 the Alzheimer's Association.
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