Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption.
LPS
antimicrobial proteins
human
immunology
infectious disease
inflammation
innate immunity
microbiology
mouse
sebaceous glands
skin
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 03 2022
02 03 2022
Historique:
received:
31
12
2021
accepted:
11
01
2022
pubmed:
3
3
2022
medline:
30
4
2022
entrez:
2
3
2022
Statut:
epublish
Résumé
Human skin functions as a physical barrier, preventing the entry of foreign pathogens while also accommodating a myriad of commensal microorganisms. A key contributor to the skin landscape is the sebaceous gland. Mice devoid of sebocytes are prone to skin infection, yet our understanding of how sebocytes function in host defense is incomplete. Here, we show that the small proline-rich proteins, SPRR1 and SPRR2 are bactericidal in skin. SPRR1B and SPPR2A were induced in human sebocytes by exposure to the bacterial cell wall component lipopolysaccharide (LPS). Colonization of germ-free mice was insufficient to trigger increased SPRR expression in mouse skin, but LPS injected into mouse skin stimulated increased expression of the mouse SPRR orthologous genes,
Identifiants
pubmed: 35234613
doi: 10.7554/eLife.76729
pii: 76729
pmc: PMC8912919
doi:
pii:
Substances chimiques
Anti-Bacterial Agents
0
Cornified Envelope Proline-Rich Proteins
0
Lipopolysaccharides
0
Membrane Proteins
0
Proline
9DLQ4CIU6V
Banques de données
GEO
['GSE182756']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : K08 AR076459
Pays : United States
Informations de copyright
© 2022, Zhang et al.
Déclaration de conflit d'intérêts
CZ, ZH, AL, MA, ME, CZ, MS, TH No competing interests declared
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