A prospective study of preconception asthma and spontaneous abortion.
Asthma severity
Maternal asthma
Miscarriage
Spontaneous abortion
Journal
Annals of epidemiology
ISSN: 1873-2585
Titre abrégé: Ann Epidemiol
Pays: United States
ID NLM: 9100013
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
12
09
2021
revised:
04
02
2022
accepted:
22
02
2022
pubmed:
3
3
2022
medline:
11
5
2022
entrez:
2
3
2022
Statut:
ppublish
Résumé
To evaluate the relationships among history of asthma, asthma severity, and spontaneous abortion (SAB). Pregnancy Study Online is a preconception cohort study of North American couples. During the preconception period, female participants reported their history of physician-diagnosed asthma, age at first diagnosis, and use of asthma medications in the previous 4 weeks. Asthma severity was classified by medication use proximal to conception, from level 0 to 3 in increasing severity. Pregnancy and SAB were identified using data from follow-up questionnaires. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Among 6325 participants who conceived, 19% experienced SAB and 17% reported a history of asthma. There was no appreciable association between asthma history and SAB incidence (HR = 0.98; 95% CI: 0.84, 1.14). HRs comparing severity levels 0, 1, and 2-3 with no asthma were 0.82 (95% CI: 0.67, 1.01), 1.20 (95% CI: 0.91, 1.60), and 1.31 (95% CI: 0.97, 1.78), respectively. Among women who conceived without the use of fertility treatment, level 2-3 severity was associated with SAB (HR = 1.39; 95% CI: 1.02, 1.89). While history of asthma diagnosis was not materially associated with SAB, having severe asthma (based on medication use) was associated with greater SAB risk.
Identifiants
pubmed: 35235814
pii: S1047-2797(22)00024-2
doi: 10.1016/j.annepidem.2022.02.006
pmc: PMC9081168
mid: NIHMS1786419
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-33Subventions
Organisme : NICHD NIH HHS
ID : R01 HD086742
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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