A Brucella melitensis H38ΔwbkF rough mutant protects against Brucella ovis in rams.
B. ovis
Brucella
Sheep
brucellosis
rough
vaccine
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
02 Mar 2022
02 Mar 2022
Historique:
received:
09
12
2021
accepted:
20
01
2022
entrez:
3
3
2022
pubmed:
4
3
2022
medline:
17
3
2022
Statut:
epublish
Résumé
Brucella melitensis and Brucella ovis are gram-negative pathogens of sheep that cause severe economic losses and, although B. ovis is non-zoonotic, B. melitensis is the main cause of human brucellosis. B. melitensis carries a smooth (S) lipopolysaccharide (LPS) with an N-formyl-perosamine O-polysaccharide (O-PS) that is absent in the rough LPS of B. ovis. Their control and eradication require vaccination, but B. melitensis Rev 1, the only vaccine available, triggers anti-O-PS antibodies that interfere in the S-brucellae serodiagnosis. Since eradication and serological surveillance of the zoonotic species are priorities, Rev 1 is banned once B. melitensis is eradicated or where it never existed, hampering B. ovis control and eradication. To develop a B. ovis specific vaccine, we investigated three Brucella live vaccine candidates lacking N-formyl-perosamine O-PS: Bov::CAΔwadB (CO
Identifiants
pubmed: 35236406
doi: 10.1186/s13567-022-01034-z
pii: 10.1186/s13567-022-01034-z
pmc: PMC8889640
doi:
Substances chimiques
Antibodies, Bacterial
0
Brucella Vaccine
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16Subventions
Organisme : Agencia Estatal de Investigación
ID : AGL2014-58795-C4-1/3/4-R
Organisme : Agencia Estatal de Investigación
ID : PID2019-107601RB-C31
Organisme : Agencia Estatal de Investigación
ID : BES-2015-075609
Organisme : Gobierno de Aragón
ID : A13_17R
Organisme : ISTUN
ID : LCF/PR/PR13/11080005
Informations de copyright
© 2022. The Author(s).
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