Immunogenicity and protection of a Pasteurella multocida strain with a truncated lipopolysaccharide outer core in ducks.
LPS
Pasteurella multocida
gatA
hptE
live attenuated vaccine
virulence
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
02 Mar 2022
02 Mar 2022
Historique:
received:
17
08
2021
accepted:
17
12
2021
entrez:
3
3
2022
pubmed:
4
3
2022
medline:
17
3
2022
Statut:
epublish
Résumé
Pasteurella multocida infection frequently causes fowl cholera outbreaks, leading to huge economic losses to the poultry industry worldwide. This study developed a novel live attenuated P. multocida vaccine strain for ducks named PMZ2 with deletion of the gatA gene and first four bases of the hptE gene, both of which are required for the synthesis of the lipopolysaccharide (LPS) outer core. PMZ2 produced a truncated LPS phenotype and was highly attenuated in ducks with a > 10
Identifiants
pubmed: 35236414
doi: 10.1186/s13567-022-01035-y
pii: 10.1186/s13567-022-01035-y
pmc: PMC8889768
doi:
Substances chimiques
Bacterial Vaccines
0
Lipopolysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17Subventions
Organisme : National Natural Science Foundation of China
ID : 32072877
Organisme : Sichuan Science and Technology Program
ID : 2019YJ0436
Organisme : Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System
ID : SCCXTD-2021-18
Organisme : China Agricultural Research System
ID : CARS-42-17
Informations de copyright
© 2022. The Author(s).
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