Microbiology and the Microbiome in Bronchiectasis.
Bacteriome
Bronchiectasis
Integrative microbiomics
Mycobiome
Virome
Journal
Clinics in chest medicine
ISSN: 1557-8216
Titre abrégé: Clin Chest Med
Pays: United States
ID NLM: 7907612
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
entrez:
3
3
2022
pubmed:
4
3
2022
medline:
6
5
2022
Statut:
ppublish
Résumé
The microbiology in bronchiectasis has been historically defined by culture-based analysis of the airway microbiome and to date has largely focused on the detection and eradication of specific bacterial pathogens. Although central to our current understanding of disease, microbial culture alone masks the holistic complexity of the microbiome and does not account for potential microbial interactions that define specific clinical phenotypes such as frequent exacerbators. Advances in next-generation sequencing including their analytical technologies can further complement and build upon our current understanding of the microbiology and microbiome in bronchiectasis providing improved patient stratification with prognostic significance.
Identifiants
pubmed: 35236558
pii: S0272-5231(21)01240-5
doi: 10.1016/j.ccm.2021.11.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-34Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Acknowledgements This research is funded by Singapore Ministry of Health’s National Medical Research Council under its Clinician-Scientist Individual Research Grant (MOH-000141) (S.H.C.) and Clinician Scientist Award (MOH-000710) (S.H.C.). S.H.C is on advisory boards for CSL Behring and Boehringer Ingelheim and has received personal fees from AZ, all outside of the submitted work. M.M.A.