ADHD in childhood predicts BMI and body composition measurements over time in a population-based birth cohort.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
06
07
2021
accepted:
09
02
2022
revised:
31
10
2021
pubmed:
4
3
2022
medline:
3
6
2022
entrez:
3
3
2022
Statut:
ppublish
Résumé
Obesity has been reported as an attention-deficit hyperactivity disorder (ADHD) comorbidity. So far, few studies have aimed to explore the potential causal relationship between ADHD and obesity, as well as used other measures of body composition like fat-free mass (FFM) and fat mass (FM) as measures of obesity. This study aimed to test the association between ADHD and body composition (body mass index [BMI] and others) and to evaluate the potential causal relationship with obesity. Data from the 1993 Pelotas (Brazil) birth cohort at age 11-, 15-, 18-, and 22-year follow-up was used. We performed a cross-lagged panel model (CLPM) analysis between ADHD symptoms and BMI to explore the causal relationship between both traits. Finally, we tested whether ADHD, inattention, and hyperactivity symptom scales were associated with BMI, FM, and FFM at 22 years. In the CLPM, higher ADHD scores at age 11 predicted higher BMI at age 15 (β = 0.055, 95% CI [0.037; 0.073]). ADHD symptoms at age 11 was also associated with a decrease in the FFM (β = -0.16, 95% CI [-0.28; -0.05]), and an increase in the BMI (β = 0.17, 95% CI [0.10; 0.23]) and FM (β = 0.17, 95% CI [0.06; 0.29]) at 22 years. At 22 years of age, ADHD was associated with FFM and FM. Moreover, an increase in BMI was observed with an increase in several symptoms of ADHD in general (β = 0.06, 95% CI [0.004; 0.12]), and hyperactivity symptoms (β = 0.15, 95% CI [0.05; 0.25]). ADHD at 11 years predicted a higher BMI at 15 years, and body fat composition in adulthood, suggesting higher scores on ADHD symptoms in early life may be a critical point for body composition in early adulthood. The hyperactivity symptoms may play an important role in the BMI increase.
Sections du résumé
BACKGROUND/OBJECTIVES
Obesity has been reported as an attention-deficit hyperactivity disorder (ADHD) comorbidity. So far, few studies have aimed to explore the potential causal relationship between ADHD and obesity, as well as used other measures of body composition like fat-free mass (FFM) and fat mass (FM) as measures of obesity. This study aimed to test the association between ADHD and body composition (body mass index [BMI] and others) and to evaluate the potential causal relationship with obesity.
SUBJECTS/METHODS
Data from the 1993 Pelotas (Brazil) birth cohort at age 11-, 15-, 18-, and 22-year follow-up was used. We performed a cross-lagged panel model (CLPM) analysis between ADHD symptoms and BMI to explore the causal relationship between both traits. Finally, we tested whether ADHD, inattention, and hyperactivity symptom scales were associated with BMI, FM, and FFM at 22 years.
RESULTS
In the CLPM, higher ADHD scores at age 11 predicted higher BMI at age 15 (β = 0.055, 95% CI [0.037; 0.073]). ADHD symptoms at age 11 was also associated with a decrease in the FFM (β = -0.16, 95% CI [-0.28; -0.05]), and an increase in the BMI (β = 0.17, 95% CI [0.10; 0.23]) and FM (β = 0.17, 95% CI [0.06; 0.29]) at 22 years. At 22 years of age, ADHD was associated with FFM and FM. Moreover, an increase in BMI was observed with an increase in several symptoms of ADHD in general (β = 0.06, 95% CI [0.004; 0.12]), and hyperactivity symptoms (β = 0.15, 95% CI [0.05; 0.25]).
CONCLUSION
ADHD at 11 years predicted a higher BMI at 15 years, and body fat composition in adulthood, suggesting higher scores on ADHD symptoms in early life may be a critical point for body composition in early adulthood. The hyperactivity symptoms may play an important role in the BMI increase.
Identifiants
pubmed: 35236922
doi: 10.1038/s41366-022-01098-z
pii: 10.1038/s41366-022-01098-z
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1204-1211Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
Références
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th rev ed. Washington, DC: APA; 2013.
WHO. World Health Organization. Obesity: preventing and managing the global epidemic. Report of a World Health Organization Consultation. ObesityTechnical Report Series. 2000;284:256.
Davis C, Levitan RD, Smith M, Tweed S, Curtis C. Associations among overeating, overweight, and attention-deficit/hyperactivity disorder: a structural equation modelling approach. Eat Behav. 2006;7:266–74.
doi: 10.1016/j.eatbeh.2005.09.006
Van der Oord S, Braet C, Cortese S, Claes L. Testing the dual pathway model of ADHD in obesity: a pilot study. Eat Weight Disord. 2018;23:507–12.
doi: 10.1007/s40519-017-0375-z
Cortese S, Castellanos FX. The relationship between ADHD and obesity: implications for therapy. Expert Rev Neurother. 2014;14:473–9.
doi: 10.1586/14737175.2014.904748
Cortese S, Holtmann M, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, et al. Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry. 2013;54:227–46.
doi: 10.1111/jcpp.12036
Sahin S, Yuce M, Alacam H, Karabekiroglu K, Say GN, Salıs O. Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor in children and adolescents with attention deficit and hyperactivity disorder. Int J Psychiatry Clin Pract. 2014;18:280–7.
doi: 10.3109/13651501.2014.940054
Link JC, Reue K. Genetic basis for sex differences in obesity and lipid metabolism. Annu Rev Nutr. 2017;37:225–45.
doi: 10.1146/annurev-nutr-071816-064827
Bowling AB, Tiemeier HW, Jaddoe VWV, Barker ED, Jansen PW. ADHD symptoms and body composition changes in childhood: a longitudinal study evaluating directionality of associations. Pediatr Obes. 2018;13:567–75.
doi: 10.1111/ijpo.12288
Ebenegger V, Marques-Vidal P-M, Munsch S, Quartier V, Nydegger A, Barral J, et al. Relationship of hyperactivity/inattention with adiposity and lifestyle characteristics in preschool children. J Child Neurol. 2012;27:852–8.
doi: 10.1177/0883073811428009
Khalife N, Kantomaa M, Glover V, Tammelin T, Laitinen J, Ebeling H, et al. Childhood attention-deficit/hyperactivity disorder symptoms are risk factors for obesity and physical inactivity in adolescence. J Am Acad Child Adolesc Psychiatry. 2014;53:425–36.
doi: 10.1016/j.jaac.2014.01.009
Schwartz BS, Bailey-Davis L, Bandeen-Roche K, Pollak J, Hirsch AG, Nau C, et al. Attention deficit disorder, stimulant use, and childhood body mass index trajectory. Pediatrics. 2014;133:668–76.
doi: 10.1542/peds.2013-3427
Cortese S, Ramos Olazagasti MA, Klein RG, Castellanos FX, Proal E, Mannuzza S. Obesity in men with childhood ADHD: a 33-year controlled, prospective, follow-up study. Pediatrics. 2013;131:e1731–8.
doi: 10.1542/peds.2012-0540
White B, Nicholls D, Christie D, Cole TJ, Viner RM. Childhood psychological function and obesity risk across the lifecourse: findings from the 1970 British Cohort Study. Int J Obes (Lond). 2012;36:511–6.
doi: 10.1038/ijo.2011.253
Cortese S, Tessari L. Attention-deficit/hyperactivity disorder (ADHD) and obesity: update 2016. Curr Psychiatry Rep. 2017;19:4. https://doi.org/10.1007/s11920-017-0754-1
De Cock N, Van Lippevelde W, Vervoort L, Vangeel J, Maes L, Eggermont S, et al. Sensitivity to reward is associated with snack and sugar-sweetened beverage consumption in adolescents. Eur J Nutr. 2016;55:1623–32.
doi: 10.1007/s00394-015-0981-3
Nguyen-Michel ST, Unger JB, Spruijt-Metz D. Dietary correlates of emotional eating in adolescence. Appetite. 2007;49:494–9.
doi: 10.1016/j.appet.2007.03.005
Perez-Bonaventura I, Granero R, Ezpeleta L. The relationship between weight status and emotional and behavioral problems in Spanish preschool children. J Pediatr Psychol. 2015;40:455–63.
doi: 10.1093/jpepsy/jsu107
Martins-Silva T, Vaz JDS, Hutz MH, Salatino-Oliveira A, Genro JP, Hartwig FP, et al. Assessing causality in the association between attention-deficit/hyperactivity disorder and obesity: a Mendelian randomization study. Int J Obes (Lond). 2019;43:2500–8.
doi: 10.1038/s41366-019-0346-8
Cortese S, Konofal E, Lecendreux M. Alertness and feeding behaviors in ADHD: Does the hypocretin/orexin system play a role? Med Hypotheses. 2008;71:770–5. https://www.sciencedirect.com/science/article/pii/S0306987708002867 .
doi: 10.1016/j.mehy.2008.06.017
Inoue Y, Howard AG, Stickley A, Yazawa A, Gordon-Larsen P. Sex and racial/ethnic differences in the association between childhood attention-deficit/hyperactivity disorder symptom subtypes and body mass index in the transition from adolescence to adulthood in the United States. Pediatr Obes. 2019;14:e12498.
doi: 10.1111/ijpo.12498
Murphy KR, Barkley RA, Bush T. Young adults with attention deficit hyperactivity disorder: subtype differences in comorbidity, educational, and clinical history. J Nerv Ment Dis. 2002;190:147–57.
doi: 10.1097/00005053-200203000-00003
Goncalves H, Wehrmeister FC, Assuncao MCF, Tovo-Rodrigues L, Oliveira IO, de, Murray J, et al. Cohort profile update: the 1993 Pelotas (Brazil) Birth Cohort follow-up at 22 years. Int J Epidemiol. 2018;47:1389–1390.
doi: 10.1093/ije/dyx249
Victora CG, Hallal PC, Araujo CL, Menezes AM, Wells JC, Barros FC. Cohort profile: the 1993 Pelotas (Brazil) birth cohort study. Int J Epidemiol. 2008;37:704–9.
doi: 10.1093/ije/dym177
Fleitlich-Bilyk B, Goodman R. Prevalence of child and adolescent psychiatric disorders in southeast Brazil. J Am Acad Child Adolesc Psychiatry. 2004;43:727–34.
doi: 10.1097/01.chi.0000120021.14101.ca
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59:22–57.
pubmed: 9881538
Amorim P. Mini International Neuropsychiatric Interview (MINI): validação de entrevista breve para diagnóstico de transtornos mentais. Brazilian J Psychiatry. 2000;22:106–15.
doi: 10.1590/S1516-44462000000300003
de Azevedo Marques JM, Zuardi AW. Validity and applicability of the Mini International Neuropsychiatric Interview administered by family medicine residents in primary health care in Brazil. Gen Hosp Psychiatry. 2008;30:303–10.
doi: 10.1016/j.genhosppsych.2008.02.001
Pagoto SL, Curtin C, Lemon SC, Bandini LG, Schneider KL, Bodenlos JS, et al. Association between adult attention deficit/hyperactivity disorder and obesity in the US population. Obesity (Silver Spring). 2009;17:539–44.
doi: 10.1038/oby.2008.587
Hanć T, Słopień A, Wolańczyk T, Dmitrzak-Węglarz M, Szwed A, Czapla Z, et al. ADHD and overweight in boys: cross-sectional study with birth weight as a controlled factor. Eur Child Adolesc Psychiatry. 2015;24:41–53.
doi: 10.1007/s00787-014-0531-1
Pauli-Pott U, Reinhardt A, Bagus E, Wollenberg B, Schroer A, Heinzel-Gutenbrunner M, et al. Psychosocial risk factors underlie the link between attention deficit hyperactivity symptoms and overweight at school entry. Eur Child Adolesc Psychiatry. 2017;26:67–73.
doi: 10.1007/s00787-016-0870-1
van Egmond-Fröhlich AWA, Widhalm K, de Zwaan M. Association of symptoms of attention-deficit/hyperactivity disorder with childhood overweight adjusted for confounding parental variables. Int J Obes (Lond). 2012;36:963–8. https://doi.org/10.1038/ijo.2012.78 .
doi: 10.1038/ijo.2012.78
Instituto Brasileiro de Geografia e Estatística. Censo demográfico 2010. Rio de Janeiro: IBGE; 2010. http://www.censo2010.ibge.gov.br/ . Accessed 20 May 2017.
Mari JJ, Williams P. A validity study of a psychiatric screening questionnaire (SRQ-20) in primary care in the city of Sao Paulo. Br J Psychiatry. 1986;148:23–6.
doi: 10.1192/bjp.148.1.23
Strimas R, Davis C, Patte K, Curtis C, Reid C, McCool C. Symptoms of attention-deficit/hyperactivity disorder, overeating, and body mass index in men. Eat Behav. 2008;9:516–8.
doi: 10.1016/j.eatbeh.2008.07.005
de Zwaan M, Gruss B, Muller A, Philipsen A, Graap H, Martin A, et al. Association between obesity and adult attention-deficit/hyperactivity disorder in a German community-based sample. Obes Facts. 2011;4:204–11.
doi: 10.1159/000329565
Fuemmeler BF, Ostbye T, Yang C, McClernon FJ, Kollins SH. Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study. Int J Obes (Lond). 2011;35:852–62.
doi: 10.1038/ijo.2010.214
Kase BE, Rommelse N, Chen Q, Li L, Andersson A, Du Rietz E, et al. Longitudinal associations between symptoms of ADHD and BMI from late childhood to early adulthood. Pediatrics. 2021;147:e2020036657.
Cortese S, Vincenzi B. Obesity and ADHD: clinical and neurobiological implications. Curr Top Behav Neurosci. 2012;9:199–218.
doi: 10.1007/7854_2011_154
Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Comings DE. Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics. 1995;5:121–41.
doi: 10.1097/00008571-199506000-00001
Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet. 2019;51:63–75. 2018/11/28
doi: 10.1038/s41588-018-0269-7
Özcan Ö, Arslan M, Güngör S, Yüksel T, Selimoğlu MA. Plasma leptin, adiponectin, neuropeptide Y levels in drug naive children with ADHD. J Atten Disord. 2018;22:896–900.
doi: 10.1177/1087054715587095
Bazar KA, Yun AJ, Lee PY, Daniel SM, Doux JD. Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disorders. Med Hypotheses. 2006;66:263–9.
doi: 10.1016/j.mehy.2005.02.042